vitamin-d-sourcesFew people are aware of the relationship between vitamin d and cholesterol, but it’s an important one and it shouldn’t be ignored. Although it’s called a vitamin, it’s actually a hormone and a deficiency of it can be life threatening!

It’s Actually a Hormone

Vitamin d refers to a number of is a fat soluble steroid molecules that are involved in the absorption of important minerals in your intestinal tract.

The two most important factors are:
vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol)

It’s also called the “sunshine vitamin” because it can be bio synthesized in your body when your skin is exposed to natural sunlight. This is especially important to people of African ancestry that live in temperate climates that have long winters.

Since their darker skin pigmentation filters out some of the suns rays, they are at increased risk of deficiency because of their skin filtering out natural sunlight (especially during long winters.)

For black people, supplements are a MUST! It appears that pretty much every disease that people of African descent suffer from disproportionately is linked with vitamin d deficiency. This is not widely known, but can still cause lots of health problems that could be avoided with wise use of supplementation.

The Cholesterol Connection

The human body is amazingly resourceful at bio synthesizing what it needs from what we put into our bodies. Thus when we have a deficiency of vitamin d the body will make it from cholesterol. This can cause your cholesterol levels to rise, because your body needs the extra cholesterol in order to synthesize this vitamin/hormone.

You have read in this blog that lowering cholesterol is not necessarily needed to prevent heart disease because it has been found not to be a direct causative factor. However if your cholesterol levels are elevated because of a lack of vitamin d then you need to take steps to supply your body with this nutrient by getting more sun exposure and taking supplements when you can’t get enough sun, such as in the winter.

Elevated cholesterol levels can indicate other problems in your body that you need to address. This is another reason why statin use can be problematic. It can mask the symptom (elevated cholesterol) that is being caused by another problem (like vitamin d deficiency).

Effects of Vitamin D Deficiency

  • increased risk of heart attack and stroke
  • depression
  • Parkinson’s Disease
  • increased risk of cancer
  • increased risk of infection
  • increased risk of multiple sclerosis

Some Food Sources of Vitamin D

  • Cod liver oil
  • Butter from grass fed cows
  • Beef or Calves liver
  • Egg yolks
  • Cheese
  • Water packed tuna
  • Oil packed sardines

Supplementing Vitamin D

Supplementary forms of this vitamin can be found in any health food store. My favorite is Jarrow Formulas D3. I opt for 5,000 units per day in the winter and half that dosage in the summer. It is difficult to overdose on this vitamin, as long as you are not using a synthetic version of it.

The ideal situation is that you get your levels tested by a doctor and do follow ups until the levels are where they are supposed to be. This is a fat soluble vitamin and so should be taken with a meal that contains healthy fats.

Vitamin k2 should be taken with vitamin d as those two nutrients work togegher to ewnsure that your body handles calcium properly. One of the top experts on vitamin K2 Dr. Rheaume Bleue suggests a ratio of 100-200 micrograms of K2 for every 1,000 IUs of vitamin d.   Again I would go with Jarrow Formulas MK-7, combined with their D3 product.

Sun Expose is Healthy

It’s been said before, but bears repeating…sun exposure is HEALTHY! Human beings evolved on the surface of the Earth. We NEED sun exposure in order for out bodies to function properly. Don’t avoid getting sunlight, because if you do, you are undermining your health in a critical way.

sunshine vitamin

sunshine helps your body synthesize vitamin D

Use common sense of course. Don’t overdo it, as too much of anything can be a problem, but remember that getting out in the sun and fresh air has benefits that go far beyond making you feel good and improving your mood.

How Much Sun Exposure?

This depends on how dark your skin is. Light skinned people should avoid prolonged exposure such as beyond 10-15 minutes in the sun. Darker skinned people of course can tolerate longer exposure, but you should be conservative with your time in the sun and gradually build a tolerance to sun exposure over time as you get more tanned.

Wearing a wide brim hat, proper sunglasses, and long sleeve clothing can help protect you as well. Remember also that you can get burned even on a hazy day because enough of the suns rays still get through and you may not be aware of how long you have been exposed.

Remember also that sunblock will prevent your body from making the vitamin d it needs from sun exposure, so If you are using sun screens on your skin you are defeating the purpose of getting sunlight.

artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

pantethine-capsulesGood cholesterol levels can be achieved easily and naturally using pantethine, which is what I call a heart healthy nutritional supplement.

It is a derivative of vitamin b5 and it’s made up of two molecules of pantothenic acid linked together by what’s called a cysteamine bridge.

It is an intermediate step in the synthesis of  Coenzyme A, which in turn is involved in various enzymatic reactions including the production and oxidation of fatty acids.

pantethine molecule

Pantethine is what’s called the “active” (more biologically available) form of the vitamin b5, but unlike the more well known form calcium pantothenate, it is less stable and will degrade if not refrigerated.

The theory is that since it’s closer biochemically to coenzyme A, it is more beneficial than pantothenic acid. It’s involved in the activation of coenzyme A and helps transport fatty acids across the cell membrane into the mitochondria to be used to make ATP, (a key component in health).

However as you will see it’s benefits go far beyond improving your cholesterol hdl ratio!

How does it work and what does it do?

Biochemistry details aside, the bottom line for the average person is “what does it do?” Dr. Stephen Sinatra has stated that in every type of heart disease, what we find is an energy starved heart! The role of pantethine in cellular energy production is a big part of it’s beneficial effect on heart health.

The heart is a very energy intense organ, and the ability for the cells of the heart to produce  energy in the form of ATP affects every aspect of your heart function, from contraction to the electrical signaling that keeps your heart beating strongly and evenly.

Pantethine is right in the middle of all of this because it is a key player in the production of ATP in the mitochondria of your cells. In plain English, it boosts energy not only to your heart, but all the organs and systems of your body!

It  has been shown (in animal experiments) to lower LDL cholesterol and raise hdl cholesterol, improving the cholesterol hdl ratio, as well as decreasing triglycerides. The ability of pantethine to promote good cholesterol levels is highly beneficial to heart health.

In addition is increases levels of apolipoprotein A1, which is the component of HDL responsible for transporting cholesterol away from the arteries and back to the liver. Pantethine also functions as an anti stress nutrient, due to the fact that it supports the health of your adrenal glands and protects the health of your hormonal system particularly when you are under stress.

Pantethione also protects your brain in several ways. It promotes the synthesis of Coenzyme A (CoA) which in turn is used in the production of the neurotransmitter acetylcholine, which is critical for healthy brain function, and a lack of this neurotransmitter can lead to Alzheimer’s Disease.

It’s positive effect on the synthesis of CoA improves the efficiency of your heart and in turn improves blood flow to the brain. Pantethine has also been shown to be beneficial for the immune system, detoxification, arthritis, and wound healing. It is used also to treat acne, and also for gout and CFS (chronic fatigue syndrome).

So the evidence is that pantethine…

  • Improves hdl cholesterol levels
  • Improves ldl cholesterol level
  • Protects the brain by boosting acetylcholine
  • Improves heart function and blood flow
  • Can be used to treat acne
  • Is helpful in Chronic Fatigue Syndrome
  • Improves detoxification
  • Strengthens the immune system
  • Combats arthritis
  • Can be used to treat gout

How is it taken (form and dosage)

Pantethine as a nutritional supplement is taken orally in capsule form. Clinical research protocols have used as little as 300mg per day with statistically significant result. Levels of 600mg to 900mg have been used in research and yielded very significant reductions in LDL levels for subjects with elevated cholesterol levels. In general though there is little information to use as a guide for precise dosage levels.

Remember that where dosages are concerned, more is not necessarily better. The best course of action would be to use this supplement under the guidance of a complementary physician who can do follow up blood work and determine the correct dosage based on that.

This supplement should work at a relatively low dose, even as low as 5mg to 50mg per day. Start with the lowest dosage and work upwards until you find what works for you.

There are home cholesterol tests that you could use to establish a baseline reference and follow up test would tell you if the pantethine was having an effect. You would have to be careful to account for all the variables in your diet and activity level, and even at that it would not be a “scientifically accurate” result, but enough for you to determine whether pantethine was actually promoting good cholesterol levels.

Side effects

Large amounts of this supplement could potentially block absorption of other b vitamins. It could also cause fatigue, numbness in your hands and feet, or headaches. It’s effect on peristalsis could cause more frequent bowel movements or diarrhea.

The toxicity of this supplement is extremely low, and it has been termed “well tolerated” which is medical jargon for having few side effects. It is not likely that toxicity would be a problem at the dosages that would have benefit.

Brands to look for

Brands I like are:  Jarrow Formulas, Life Extension, and Pure Encapsulations. You really can’t go wrong with these companies when it comes to the quality of the supplements they sell. To be sure there are other good brands, but these are the ones I know of to be top notch.

To Sum Up

This is a supplement that can be helpful in many conditions due to it’s vital role in cellular energy production. Think of it less as something “medicinal” and more as a substance your body needs to create energy that powers all of your biochemical reactions.

Pantethine can be a powerful addition to your nutritional arsenal when it comes to promoting good cholesterol levels, combating heart disease and protecting your brain function. This article should be a starting point for your investigation and use of this fascinating supplement!

soy lecithing granules

Lecithin as a food to lower cholesterol is another natural strategy to improve your lipid (fat) profile without the use of toxic drugs, such as statins.

Lecithin is a compound found in soybeans, eggs,  sunflower, and other sources, which has the ability to help lower cholesterol levels.

Remember that when we talk about lowering cholesterol, we are really referring to optimizing your cholesterol levels. Cholesterol is often elevated by other things going on in the body. Things like insulin resistance, vitamin-d deficiency, and stress can all raise cholesterol levels.

When levels are high often this indicates that there are problems with the body that can be serious if they are not taken care of. High cholesterol levels are like the “canary in the coal mine” so to speak. If they are elevated we need to make sure we know why, and correct it.

Lecithin (also called phosphatidylcholine) is a “phospholipid compound” that supplies the b-vitamin choline, which is vital to the health of your brain and nervous system. This natural compound (lecithin) can help promote healthy cholesterol levels, but there are some things you need to know before you add it to your diet!

As a food to lower cholesterol, soy lecithin (from soybeans) may not be the best way to go, as soy contains phyto-estrogens and can cause a number of problems especially for men.  Sunflower lecithin on the other hand does not pose those problems and so would be a much better way to go, if you are using it to improve your cholesterol profile.

The following foods are sources of lecithin:

  • Animal sources:  eggs, meat, dairy
  • Vegan sources:   nuts, seeds, soy, sunflower

Eggs contain the highest amounts for any animal based food, and if you are a vegetarian, you would likely have to supplement with lecithin granules, preferably made from sunflower plants, instead of soybeans.

These lecithin granules have a pleasant nutty flavor and can be added to either liquid or solid food depending on your taste and preferences. They are one of the few things that are good for you that actually taste good!

This food does act as an emulsifier (mixes water and oil) and can be used in blending protein drinks or vegetable smoothies such as you might make in the Nutribullet! Dr. Peter D’Adamo has a recipe for something he calls the “Membrane Fluidizer Cocktail,” or “Membrosia Cocktail.”

The recipe goes something like this:

Use guava, grapefruit, or watermelon juice as a base
add 1/2 to 1 tablespoon of high-quality flaxseed oil
plus 1 tablespoon of good-quality lecithin granules
shake well until the consistency is uniform
and..enjoy!

Buying and storing lecithin

Make sure that the lecithin granules that you buy in the store are kept under refrigeration, because they oxidize (turn rancid) very easily when they are exposed to light or heat. Always check the expiration dates and pick the freshest bottle. When you get home store your lecithin in the refrigerator at all times!

Lecithin to lower cholesterol……does it work?

I have been unable to find any evidence that lecithin acts as an emulsifier and “flushes” the cholesterol out of your arteries as some people claim. It just doesn’t appear to work in this way. However choline is necessary for optimal health and promoting healthy cholesterol levels.

As a food to lower cholesterol, lecithin provides your body with a good source of choline and for this reason it likely has a positive effect on cholesterol levels. The benefits of lecithin from food sources and supplementation is really enhancing the function of your brain and nervous system.

Since the nervous system is involved in regulating cholesterol metabolism, any thing you do to make it function better will result in an improvement in your cholesterol profile.

Supplementary lecithin comes in either granules or gel caps, which are rather large and may be hard to swallow. When I use lecithin I prefer the granules, and I try to use sunflower lecithin rather than soy lecithin for the reasons I mentioned above.

Do not put lecithin into anything hot, as heat degrades lecithin (it’s poly unsaturated). Follow the dosage recommendations on the label. Since lecithin is a concentrated source of choline, you don’t need a lot.

Remember that lecithin, as a food to lower cholesterol does work but not for the reasons you have likely been told. It provides choline to your body which is essential to the health of your nervous system and thus your body’s ability to maintain healthy cholesterol levels.

medical references:

J Nutr. 1990 Jul;120(7):659-67.
Evidence that polyunsaturated lecithin induces a reduction in plasma cholesterol
level and favorable changes in lipoprotein composition in hypercholesterolemic
rats.
Jimenez MA1, Scarino ML, Vignolini F, Mengheri E.

J Am Diet Assoc. 2003 May;103(5):577-81.
Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol
absorption and LDL cholesterol.
Spilburg CA1, Goldberg AC, McGill JB, Stenson WF, Racette SB, Bateman J,
McPherson TB, Ostlund RE Jr.

Atherosclerosis. 1998 Sep;140(1):147-53.
Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in
hypercholesterolemic monkeys and hamsters: beyond linoleate.
Wilson TA1, Meservey CM, Nicolosi RJ.

HDL cholesterol level is the most important factor in your cholesterol profile. The cholesterol hdl ratio is used to determine your risk of a heart attack or stroke. Low hdl means greater risk, and I will explain the reasons why.

hdl cholesterol levelThe effect of cholesterol on your heart health has been distorted by bad information over the years. This is because pharmaceutical companies want to sell statin drugs, so they influenced doctors to set up guidelines that call for proscribing these drugs for lowering cholesterol levels.

The drugs do not lower cholesterol naturally, they do it by interfering with your body’s natural production of lipids, which is unhealthy and dangerous. What makes cholesterol a problem in your arteries is inflammation and free radicals which oxidize the cholesterol and turn it into hard plaques. Hdl cholesterol prevents this process, and protects you against heart disease.

How to raise increase good cholesterol

We know that HDL cholesterol functions as an antioxidant in the body. This means that it will help prevent LDL cholesterol from turning into dangerous plaques inside your arteries. This is why the cholesterol HDL ratio can predict your risk of heart disease. The higher the HDL cholesterol levels, the lower your risk.

So just how do we increase good cholesterol? We do it by diet, exercise, and using certain nutritional supplements that help boost HDL  levels.

Let’s start with diet! Below are some foods that can help increase good cholesterol:

  • Fatty fish such as salmon, tuna, mackerel, sardines
  • Raw nuts and seeds like walnuts, pecans, almonds, and flaxseeds
  • Whole eggs (yes that’s right…they must be WHOLE eggs)
  • Onions
  • Fresh raw low glycemic vegetables – especially dark leafy greens
  • Oat bran
  • Alcohol – 1 or 2 drinks per day maximum

These foods work in a natural way by giving your body the raw materials such as essential fatty acids it needs to raise  HDL!

Nutritional Supplements

Nutritional supplements can also help you increase good cholesterol

  • Fish oil
  • Pantothenic acid (vitamin B-5)
  • niacin – (vitamin B-3)
  • Gugulipid
  • Coenzyme Q-10
  • Carnitine
  • Vitamin-C
  • Vitamin-D
  • Magnesium
  • Polycosanol
  • Vitamin E-complex
  • Alpha Lipoic Acid
  • N-Acetyl-Cysteine
  • CLA – conjugated linoleic acid

All of these supplements help increase HDL levels, however niacin (B-3) and calcium pantothenate (B-5) are the most effective, so you should focus on them first, and add others if needed.

Exercise to raise your HDL cholesterol level

The best form of exercise is some kind of internal training. This might be circuit weight training, kettlebells, bodyweight exercises, ect. The main principle is the workouts should be brief, intense, and make your heart and lungs work hard.

Naturally, if you are older, or not on good health, you should get clearance from your doctor before engaging in strenuous exercise. You should also work into an exercise program gradually so that your body gets used to it. Never jump right into an intense exercise program. Take time to build up your exercise capacity so that you don’t overdo it.

The PACE program by Dr. Al Sears is an excellent exercise system for this!

Just what are good HDL cholesterol levels?

Remember that the cholesterol HDL ratio is very important. That determines your risk of heart attack. The table below reflects the Amercian Heart Association guidelines:

American Heart Association Guidelines

Desirable Borderline Risk
High Risk
HDL
60 or higher
40 to 59
40 or less (men)
HDL
60 or higher
50 to 59
50 or less (women)

Action steps to raise for your HDL cholesterol level:

  • Get your cholesterol HDL ratio tested so you know what they are to start
  • Work in 3 15 minute sessions of circuit or interval training per week
  • Avoid refined foods if possible – stick to raw fruits and vegetables
  • Get plenty of healthy fats in your daily diet
  • Supplement with niacin (B-3) and calcium pantothenate (B-5) to raise HDL

Your HDL cholesterol level is one of the best predictive markers for heart disease that we know of. HDL cholesterol protects you against heart disease, stroke, cancer, and Alzheimer’s disease. Make it a point to get your HDL cholesterol levels checked, get them into the healthy range and keep them there. Your heart will thank you!

pantothenic acid capsulesPantothenic acid benefits are not well known to most people but they have important effects on your cardiovascular health. D-calcium pantothenate is helpful in raising HDL cholesterol level, which helps lower your risk of heart disease.

Since the cutting edge in modern medicine involves the use of targeted nutritional supplements to fight disease rather than defaulting to drugs as a first resort, we need to become familiar with some key nutrients and learn how they can help protect against heart disease!

What is pantothenic acid?

D-calcium pantothenate or pantothenic acid is a water soluble b-vitamin (vitamin-b5). It is a very important nutrient and is a precursor to coenzyme A. Coenzyme A is utilized in the metabolism of carbohydrates, and the synthesis of fatty acids, and steroid hormones.

Deficiency of this vitamin in human beings is rare and usually only occurs in bad cases of malnutrition. Symptoms of deficiency include numbness and tingling in the hands and feet, fatigue, headaches, and insomnia.

Pantothenic acid benefits

There are a number of well documented health benefits associated with d-calcium pantothenate such as:

  • Raises HDL cholesterol level
  • Improves skin tone
  • Accelerates healing
  • Protects against lipid peroxidation
  • Increases energy levels
  • Accelerates post surgery healing
  • Helps healing after burn injuries
  • Enhances epithelial function

The most important of the pantothenic acid benefits is it’s ability to raise HDL levels. This is what most directly affects your risk of heart disease. Pantethine is the active form of vitamin B5. Clinical research studies show that pantethine can reduce triglycerides and cholesterol levels and increase HDL levels at the same time.

Food sources of d-calcium pantothenate

Pantothenic acid can be found in common foods and also taken in supplement form. You can get it in the following foods:

  • Meats
  • Whole grains
  • Egg yolks
  • Vegetables like broccoli and avocado
  • Rice
  • Cold water fish

Pantothenic acid benefits can also come from supplements of d-calcium panothenate taken in dosages of 50-100 mg per day. There is no known toxicity threshold for this nutrient and dosages of several grams per day have been reported as having beneficial effects with no signs of toxicity.

Since few doctors are familiar with nutritional supplements and how they should be used, your doctor will probably not be receptive to the idea or know just how these nutrients should be incorporated into your diet.

You should seek the advice of a doctor who practices complementary and integrative medicine, as the best person to advise you in this area. These doctors combine traditional treatments with nutrition and holistic therapies, to get the best results of both approaches.

The best approach is to calibrate the dosage with how you feel and what your objectives are. Raising HDL cholesterol is the most notable of d-calcium pantothenate effects, and you should adjust your dosage to optimize your HDL levels. You may want to have your HDL cholesterol checked to provide a baseline to compare against. This way you will know if it is working.

Pantothenic acid benefits are that this powerful nutrient can help optimize your cholesterol profile and significantly lower your risk of heart disease. It is non toxic and vital to energy production. When you add this vitamin to your nutritional regimen you will significantly improve the quality of your life.

niacin taken to lower cholesterolNiacin for cholesterol has for years been the choice of natural supplements that lower cholesterol.  Niacin (vitamin b-3) can improve cholesterol profiles when used in high doses such as 1,000 to 3,000 milligrams per day.

The use of niacin to lower cholesterol has a lot of sound scientific research behind it. It is considered to be the most effective way to lower cholesterol naturally that is currently available.

This is far above the MRD (minimum daily requirement for vitamin b-3, so when it’s being used to lower cholesterol levels, we call that a “therapeutic dose.” These dosages will cause a reaction call a “niacin flush,” which if you are not used to it may be a little disturbing.

This flushing can be controlled by gradual increases in the dosage so that the body has time to adjust and does not react as strongly.

When using niacin for cholesterol, your skin will turn red and you will feel itchy. This is due to what’s called vasodilation. Niacin (also referred to as nicotinic acid) will lower cholesterol levels, reduce triglycerides, and improve the cholesterol hdl ratio, by boosting hdl levels.

Recent studies have shown that a lower dose (1.5 grams/day) of niacin is effective in lowering ldl levels and also boosting hdl levels. This dosage is better tolerated by the majority of people and is thought to be relatively safe for the liver.

Non-flush – niacin for cholesterol

There is a form of niacin that will not trigger as much flushing as regular niacin. The information on this form is contradictory, but some research indicates that it can be effective at both lowering ldl and raising hdl. It’s called extended release niacin.

People DO still get some flushing from this form, but much less. The issue of people not taking the regular form of niacin to lower cholesterol is because of the unpleasant flush, is not a problem with extended release niacin. Because it is so much milder, it may be more effective simply because people will not avoid taking it. This is called “patient compliance” in medical terms.

Together with using extended release niacin, other strategies to lessen the flush reaction are taking it with meals or snacks, and avoiding alcohol when taking it.

Niacin to lower cholesterol – dosage and side effects

Taking niacin for cholesterol, inhibits the breakdown of hdl in the body, which obviously results in higher hdl levels and a better cholesterol hdl ratio. Higher hdl levels alone lower the risk of heart disease, but niacin helps in another way, by lowering ldl levels as well.

Niacin taken at (1-3 grams/day) prevent the breakdown of fats which the liver uses to make lipoproteins. This lowers levels of both ldl and triglycerides, a very beneficial result. Lower triglyceride levels result in lower levels of ldl cholesterol which also lowers risk of heart attacks.

Side effects beyond the flushing reaction are rare but can include alterations in blood pressure, gastrointestinal distress, and liver damage. Although vitamins that lower cholesterol are safer than drugs, you really should seek expert medical advice when using niacin for cholesterol, both from the standpoint of safety and effectiveness.

You also need medical advice to avoid potential bad reactions from taking niacin for cholesterol with any drugs that you are on. Again the advice of a doctor is needed, because they are familiar with side effects and adverse reactions from combining drugs and nutrients.

Natural supplement or prescription

Odd as it might seem there ARE prescription forms of niacin. I have no information which suggests they work any better than what you can get over the counter, and in fact, they may have more side effects depending on how they were formulated.

If you are advised to take a prescription form of niacin for cholesterol, research the side effects very carefully as they are likely to be greater than what you would get with a natural supplement. You want to lower cholesterol naturally and safely!

Remember also that as effective as niacin is, you have to do all of the other things which protect you from heart disease, like eating a healthy diet, getting the right exercise, and reducing your stress. These strategies work together to keep your heart healthy.

The MTHFR gene is a hidden culprit in heart disease and explains much in the reasons why cholesterol numbers don’t tell you what your real risk for heart disease is. Understanding how this gene defect affects your good cholesterol levels and how to treat it is essential to protecting yourself from heart attacks.

MTHFR geneWhat is the MTHFR Gene?

This gene is responsible for operating what are called “methylation pathways” that involve your body’s ability to convert certain substances into their reduced or active form. If this gene is defective in your body, these vitally important methylation processes cannot be completed properly, and certain substances (vitamins and amino acids) can’t be absorbed by your body and you develop deficiencies.

Some of these substances are:

  • vitamin b-12
  • folic acid
  • cystiene

In the case of b-12 and folic acid, these substances are converted to their active forms of methylfolate and methylcobalamin. These active forms are what your body can actually use, and so if you can’t convert them properly, you end up with a deficiency.

Cystiene is converted to the toxic amino acid homocysteine and then to methionine. If your methylation pathways are not working properly due to the MTHFR gene defect, then you end up with an accumulation of homocystiene which is highly inflammatory and causes damage to your arteries.

How is Your Good Cholesterol Level Affected?

HDL-C also called the “good cholesterol,” can be effectively lowered by a certain type of MTHFR gene defect called: C677T polymorphism.  Since HDL is protective and lowers your risk of heart disease, this gene defect can raise your risk by lowering your good cholesterol level.

There are several variants of this gene defect, and they affect cardiovascular risk in different ways, but it’s important to be aware of their impact so that you can protect yourself. Remember that 50% of heart attacks occur in people who have what’s considered normal cholesterol levels.

The affect of the MTHFR gene is seen by many researchers as the missing piece of the puzzle in trying to determine why this is so. With this information you can go about protecting yourself by applying this new knowledge and lowering your risk not only for heart disease, but also for other chronic diseases that are caused by inflammation.

What Other Problems Can This Lead To?

A defect in the MTHFR gene can also result in increase risk for the following diseases:

  • Cancer
  • Stroke
  • Fibromyalgia
  • Polyneuropathy

How Do You Know if You Have it?

This is a very important question, because once you detect this, then you can guard against it’s effects. The most simple test you can do is to eat asparagus and note if your urine has a strong odor in the hours following your meal.

If this odor is present when you urinate, (you can’t miss it), then you can be sure that you do in fact have a defect (called a polymorphism) in the way your MTHFR gene operates. There are also lab tests that your doctor can do to detect this problem.
It may be necessary to have formal lab tests done so that this problem can be medically verified. It’s also important because your doctor has to order it for your insurance to cover it. The best and most responsible advice I can give you is to go through your doctor and get tested for this.

Fortunately there are ways to treat this problem, that will work and help to protect your health, but of course the first step is to determine whether you have it or not, and your doctor can order the tests to confirm it.

What Can I Do?

A defect in the MTHFR gene results in failure to operate certain methylation pathways and convert amino acids properly. However, forms of critical b-vitamins, vitamin B-12, and Folic acid, in their “active” forms, which means they do not have to be converted or methylated, CAN be absorbed by your body and help ensure these critical chemical reactions happen as they are supposed to.

Thus instead of taking folic acid, you would take “methyl-folate.” Instead of taking vitamin B-12 (cyanocobalamin) you would take “methylcobalamin.”

There are other substances that can help. They are called “methyl donors” because they donate or provide what’s called a “methyl group” to help the chemical reaction complete properly. There are foods that contain “methyl donors,” such as garlic, onions, avocadoes, ect.

There are also nutritional supplements such as trimethylglycine, and SAMe, as well as special formulations that contain combinations of these methyl donors to help provide what your body needs to do these conversions properly.

None of these substances are drugs, nor are they prohibitively expensive. However, most mainstream doctors do not know about them, nor about defects in the MTHFR gene, and so you may have to search for a physician that is up on the latest genetic research, that can help you safely manage this problem.

The website I recommend is:

http://mthfr.net/

which is a website run by Dr. Benjamin Lynch. There is a wealth of information on this website regarding methylation issues and the MTHFR gene. If you have this gene defect, I would highly recommend that you visit this website and educate yourself.

You can also click on this video:

to learn more about this topic, and start arming yourself with powerful information that will allow you to protect yourself against heart disease, cancer, strokes, Alzheimers, and other effects of methylation problems.

My reasons for delving into this topic is that it fills in the missing information that cholesterol numbers leave out. The effects of this gene defect on your good cholesterol level is probably one of the main reasons for the increased risk of heart disease.

Defects in the MTHFR gene are one of the most significant drivers of chronic disease, and by knowing if you carry this defect, you can takes very strong steps to protect your health and to live better and longer.

references:

Cardiovasc Diabetol. 2012 Oct 8;11:123. doi: 10.1186/1475-2840-11-123.
Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels.

J Atheroscler Thromb. 2009;16(6):815-20. Epub 2010 Jan 9.
Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia.

J Hum Genet. 2001;46(9):506-10.
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis.

 

High cholesterol symptoms are not something you are going to notice. In fact they are almost non existent! The real relationship between cholesterol and heart disease kind of forced me to write this article backwards.

high cholesterol symptomsThe truth is that high cholesterol (let’s call anything beyond about 280 mg/dl high) is itself a symptom of other medical problems. You see, cholesterol is made by the body and used in all sorts of important biochemical reactions, some having to do with healing and the immune system.

Cholesterol also serves as an antioxidant as well, and your body will make more of it when you are faced with any kind of a health crisis or trauma, because it’s part of the protective and healing systems of the body.

So when cholesterol is elevated, it can be an indicator that something is wrong in the body, and that the body is attempting to heal or correct the problem.

Are there any real high cholesterol symptoms?

The answer is yes, although it’s not something that you would feel or notice on a day to day basis. It can show up during an eye examination. Your eye doctor may notice a buildup of cholesterol deposits in your eyes.

This CAN be an indicator of high cholesterol (kind of a “silent symptom”) that is itself, a symptom of other medical problems.

Arcus Senilis

There is a condition that affects the eyes called Arcus Senilis where a white or gray ring develops around the cornea of the eye.  It CAN be caused by elevated cholesterol, but not always. The rings come from cholesterol deposits but may be due to a metabolic disorder, rather than very high levels of cholesterol.

If you notice these rings, of course you should have your eyes checked, but again, this does not mean that you necessarily have a high cholesterol level. You eye doctor may recommend that you see another specialist and have the necessary tests done to determine if indeed your lipid profile (fat levels) are really elevated.

In people over 40, this condition is not all that uncommon, but really isn’t a reason for concern. In younger people it can be due to something called familial hyperlipidemia, which is a genetic condition where the person tends to have high levels of fats in their blood. In any case, if you have this condition, the best strategy is to have an eye exam and a full blood lipid screening.

The bottom line is that Arcus Senilis is a normal occurrence after 40 years of age. It’s nothing to get stressed about, but just follow up and get your blood lipids tested by your doctor. If you are a young person, it may indicate a problem with cholesterol metabolism and again should be checked out and dealt with accordingly.

High Cholesterol Symptoms That Are Silent

Again, try not to think of “high cholesterol” in and of itself as THE problem. For the most part, it’s an indicator that your body is trying to deal with another problem and the elevation in cholesterol is just it’s way of doing so. This is known in medicine as “acquired hyperlipidemia,” which means high blood fats due to some medical condition that is causing elevations in your cholesterol levels.

Your body may increase it’s cholesterol levels in response to health issues like:

  • Vitamin-D deficiency
  • Hypothyroid (sluggish thyroid function)
  • Cushings Disease (which causes chronically elevated cortisol levels)
  • Anorexia
  • Problems with your hormones and metabolism
  • Kidney disease
  • Alcoholism and alcohol toxicity
  • Diabetes and pre-diabetes

Obviously these are serious medical conditions and if you have any of these issues, your doctor should be monitoring your blood lipid profile (cholesterol and triglycerides) on a constant basis.

Drugs that Affect Cholesterol Levels

  • Estrogen and Corticosteroids (can raise HDL and Triglycerides)
  • Oral Anabolic steroids ( lower HDL)
  • Birth Control (can raise cholesterol)
  • Beta Blockers (can raise triglycerides and lower HDL)
  • Thiazide Diuretics (can raise cholesterol and triglycerides)
  • Retinoids (can increase LDL and triglycerides)

Of course if you are on any of these medications, you will have to discuss the side effects and risk to benefit ratio with your doctor. Don’t just go off medications without consulting your doctor, because this can have serious consequences.

If you are searching for an healthier or less risky alternative to drugs, that’s great, but you have to do that under the guidance of a physician who knows your medical history and can help you do so safely.

High cholesterol symptoms are a sign that there are important health issues that you and your doctor need to be dealing with. Since most people get routine lipid screenings your doctor should be aware of your lipid profile and it’s implications, but always do your own research and work with your doctor to identify problem areas and find the healthiest solutions you can for them.

Cholesterol too low, how can this be a problem? We have all heard about the supposed relationship of heart disease to cholesterol levels, so we assume that lower is better. NOT SO!

cholesterol too lowEverything in your body is based on maintaining a balance, and cholesterol profiles are no exception.  Low cholesterol levels can be just as unhealthy as levels that are too high.

The belief that simply lowering cholesterol will protect you from heart attacks has been encouraged by the pharmaceutical industry and those medical professionals that serve it.  While cholesterol is a factor, there are other things involved such as inflammation, that make a big difference.

The risks of various serious medical conditions rise for those individuals having a total cholesterol level of under 160 mg/dl (milligrams per deciliter).  That said, some experts recommend that the ideal is somewhere between 180mg/dl and 200mg/dl for total cholesterol, (but even this is subject to controversy)

What causes low cholesterol?

Cholesterol that’s too low can be caused by:

  • Use of statin drugs
  • Malnutrition
  • Malabsorption – inadequate absorption of nutrients from the intestines
  • Hyperthyroidism
  • Liver dysfunction
  • Manganese deficiency
  • Celiac disease
  • Leukemia and other blood diseases

Please note:  Excessively low cholesterol levels need to be evaluated by a trained medical professional to determine the cause and the proper treatment. It is important not only to know what causes low cholesterol, but also having a proper treatment strategy in place to make sure you address it.

When you optimize cholesterol naturally, this is not a problem, because you are not trying to curtail your own body’s production of cholesterol, but rather preventing re-absorption through the large intestine.

You will NOT bring your cholesterol too low with this approach.

Effects of low cholesterol

Hypocholesterolemia – cholesterol too low, has been associated with a number of serious medical disorders such as:

  • Reduced production of your body’s steroid hormones
  • Increased risk of cancer
  • Increased risk of heart disease
  • Increased risk of strokes
  • Increased risk of depression/bipolar disorder
  • Increase risk of Alzheimer’s disease
  • Loss of sex drive
  • Possible loss of memory
  • Increased risk of suicide
  • Increased risk of schizophrenia

Effects of low cholesterol are very serious, and you need to focus not on simply lowering cholesterol, but achieving a healthy level based on your individual biochemistry.  With cholesterol too low, many vital chemical processes can’t be completed properly.

Cholesterol too low? – So what is the right approach?

The correct approach is not to simply focus on lowering cholesterol, just as weight loss should not simply be about losing weight.  Rather than making your cholesterol too low, this process will allow you to achieve the right balance.

That process includes:

  • Proper eating
  • Proper exercise
  • Nutritional supplementation
  • Stress reduction

Proper eating should include foods that are low in cholesterol but also nutrient dense, and which contain plenty of fiber. This is because fiber can absorb excess cholesterol as it passes through the large intestine and is then excreted out of the body in the stool.  The recommended fiber consumption is about 25 grams per day for women and 38 grams per day for men.

Proper exercise is short and intense, like interval training, but ultimately should be moderated by the age and physical condition of the person doing it. Be cautious and seek professional guidance in setting up an exercise program if you are an older person, or if you have a serious medical condition.

Nutritional supplementation should include full spectrum vitamin and mineral formula. A high quality fish oil is also a key supplement that will lower your risk of heart disease and every other medical condition you can think of. Sufficient levels of omega 3 fatty acids are essential to good health, and fish oil supplies these.

Stress reduction uses various techniques to lower stress and promote relaxation and tranquility. Among these, grounding is one of the most effective. Other strategies like meditation, the speed trace, and various other relaxation techniques can be very effective.

Having your cholesterol too low is a risk factor for chronic disease. A balanced approach, rather than just low cholesterol levels is the answer. Doing the things mentioned above should allow you to naturally achieve the right balance.