pantethine-capsulesGood cholesterol levels can be achieved easily and naturally using pantethine, which is what I call a heart healthy nutritional supplement.

It is a derivative of vitamin b5 and it’s made up of two molecules of pantothenic acid linked together by what’s called a cysteamine bridge.

It is an intermediate step in the synthesis of  Coenzyme A, which in turn is involved in various enzymatic reactions including the production and oxidation of fatty acids.

pantethine molecule

Pantethine is what’s called the “active” (more biologically available) form of the vitamin b5, but unlike the more well known form calcium pantothenate, it is less stable and will degrade if not refrigerated.

The theory is that since it’s closer biochemically to coenzyme A, it is more beneficial than pantothenic acid. It’s involved in the activation of coenzyme A and helps transport fatty acids across the cell membrane into the mitochondria to be used to make ATP, (a key component in health).

However as you will see it’s benefits go far beyond improving your cholesterol hdl ratio!

How does it work and what does it do?

Biochemistry details aside, the bottom line for the average person is “what does it do?” Dr. Stephen Sinatra has stated that in every type of heart disease, what we find is an energy starved heart! The role of pantethine in cellular energy production is a big part of it’s beneficial effect on heart health.

The heart is a very energy intense organ, and the ability for the cells of the heart to produce  energy in the form of ATP affects every aspect of your heart function, from contraction to the electrical signaling that keeps your heart beating strongly and evenly.

Pantethine is right in the middle of all of this because it is a key player in the production of ATP in the mitochondria of your cells. In plain English, it boosts energy not only to your heart, but all the organs and systems of your body!

It  has been shown (in animal experiments) to lower LDL cholesterol and raise hdl cholesterol, improving the cholesterol hdl ratio, as well as decreasing triglycerides. The ability of pantethine to promote good cholesterol levels is highly beneficial to heart health.

In addition is increases levels of apolipoprotein A1, which is the component of HDL responsible for transporting cholesterol away from the arteries and back to the liver. Pantethine also functions as an anti stress nutrient, due to the fact that it supports the health of your adrenal glands and protects the health of your hormonal system particularly when you are under stress.

Pantethione also protects your brain in several ways. It promotes the synthesis of Coenzyme A (CoA) which in turn is used in the production of the neurotransmitter acetylcholine, which is critical for healthy brain function, and a lack of this neurotransmitter can lead to Alzheimer’s Disease.

It’s positive effect on the synthesis of CoA improves the efficiency of your heart and in turn improves blood flow to the brain. Pantethine has also been shown to be beneficial for the immune system, detoxification, arthritis, and wound healing. It is used also to treat acne, and also for gout and CFS (chronic fatigue syndrome).

So the evidence is that pantethine…

  • Improves hdl cholesterol levels
  • Improves ldl cholesterol level
  • Protects the brain by boosting acetylcholine
  • Improves heart function and blood flow
  • Can be used to treat acne
  • Is helpful in Chronic Fatigue Syndrome
  • Improves detoxification
  • Strengthens the immune system
  • Combats arthritis
  • Can be used to treat gout

How is it taken (form and dosage)

Pantethine as a nutritional supplement is taken orally in capsule form. Clinical research protocols have used as little as 300mg per day with statistically significant result. Levels of 600mg to 900mg have been used in research and yielded very significant reductions in LDL levels for subjects with elevated cholesterol levels. In general though there is little information to use as a guide for precise dosage levels.

Remember that where dosages are concerned, more is not necessarily better. The best course of action would be to use this supplement under the guidance of a complementary physician who can do follow up blood work and determine the correct dosage based on that.

This supplement should work at a relatively low dose, even as low as 5mg to 50mg per day. Start with the lowest dosage and work upwards until you find what works for you.

There are home cholesterol tests that you could use to establish a baseline reference and follow up test would tell you if the pantethine was having an effect. You would have to be careful to account for all the variables in your diet and activity level, and even at that it would not be a “scientifically accurate” result, but enough for you to determine whether pantethine was actually promoting good cholesterol levels.

Side effects

Large amounts of this supplement could potentially block absorption of other b vitamins. It could also cause fatigue, numbness in your hands and feet, or headaches. It’s effect on peristalsis could cause more frequent bowel movements or diarrhea.

The toxicity of this supplement is extremely low, and it has been termed “well tolerated” which is medical jargon for having few side effects. It is not likely that toxicity would be a problem at the dosages that would have benefit.

Brands to look for

Brands I like are:  Jarrow Formulas, Life Extension, and Pure Encapsulations. You really can’t go wrong with these companies when it comes to the quality of the supplements they sell. To be sure there are other good brands, but these are the ones I know of to be top notch.

To Sum Up

This is a supplement that can be helpful in many conditions due to it’s vital role in cellular energy production. Think of it less as something “medicinal” and more as a substance your body needs to create energy that powers all of your biochemical reactions.

Pantethine can be a powerful addition to your nutritional arsenal when it comes to promoting good cholesterol levels, combating heart disease and protecting your brain function. This article should be a starting point for your investigation and use of this fascinating supplement!

Natural hormone therapy for optimizing cholesterol has not yet gone mainstream in medicine, but it is going to be a popular new therapy in years to come. Bioidentical hormone therapy is a very safe and natural approach that will help people optimize cholesterol naturally and protect themselves from heart disease as they get older.

As you age, your hormonal systems begins to weaken, and that means that the amounts of critical hormones like, testosterone, DHEA, TSH, estrogen, and progesterone begin to decline. Since all of these hormones need to be in balance for your body to function properly, things begin to go wrong when one or more of these hormones decline, because then that delicate balance can no longer be maintained.

Medical science has slow to embrace natural hormone therapy for optimizing cholesterol , because this idea was considered radical due to misunderstanding by the scientific community. Recent studies have shown a strong correlation between declining hormones and higher cholesterol levels.

Clearly there is a link, and it appears as though restoring hormones to more youthful levels can normalize cholesterol quite effectively. This is logical because when you were younger and your hormone system was stronger and putting out higher levels of these critical hormones, your cholesterol levels were probably lower.

As you aged and your hormone system put out less and less of these hormones, your body was unable to maintain the healthier cholesterol profile your youth. It only makes sense that if you could go back to a more youthful hormone profile, you could significantly lower your risk of heart disease, and probably many other chronic diseases as well.

With that said, lets take a brief look at some research on natural hormone therapy for lowering cholesterol.

Why do declining hormones trigger increases in cholesterol levels?

The body uses cholesterol to make steroid hormones, and the theory is that when the levels of these hormones drop with age, the body tries to provide more cholesterol to the endocrine (hormonal) system to make hormones with.

To confirm this hypothesis, doctors Arnold Smith and Sergey Dzugan conducted a clinical research study on 41 patients with high cholesterol from 1997 to 2003. The results astounded them! In the study they replaced the hormones these patients were lacking, and all subjects experienced a significant drop in their blood cholesterol levels.

When using natural hormone therapy for optimizing cholesterol, it appeared that when normal hormone levels were restored, their bodies “down-regulated” (lowered output) of cholesterol from the liver. This suggests there is a mechanism whereby the body thinks the lower hormone levels are due to a lack of cholesterol, and so it increases it’s cholesterol production to give the body the “precursors” (necessary chemicals) to create these critical hormones.

Furthermore by lowering cholesterol “too much” we you could very well be preventing your body from synthesizing it’s critical hormones by limiting the cholesterol it needs to do it’s job. Nobody ever thinks about the fact that cholesterol is a vital and necessary substance, and that the only way you should go about trying to optimize it is by a natural process, not synthetic drugs.

Natural hormone therapy for lowering cholesterol is the correct approach because it takes into consideration how the body functions, and works with the body’s natural processes to lower cholesterol naturally.

The type of natural hormone therapy that I am speaking of is called bioidentical hormone therapy. It consists of a doctor doing blood and saliva testing on the patient to determine that baseline levels of all of the critical hormones, and then creating a prescription for the necessary hormones to be corrected. This is the principle behind natural hormone therapy.

This prescription is then processed by a compounding pharmacy using plant based hormones that are identical on the molecular level to what your own body produces. The dosages of these hormones the doctor prescribes are very precise and designed to get your critical hormone levels into the middle to high normal range.

This ensures that you only use just enough to create optimal health, and that any possible side effects are minimized or eliminated.

Natural hormone therapy for lowering cholesterol is one of the most effective and natural methods for lowering high cholesterol. It is backed by good scientific research and works WITH your body to safely lower cholesterol levels, rather than interfere with your body’s natural functions as statin drugs do.

References:

Med Hypotheses. 2002 Dec;59(6):751-6.
Hypercholesterolemia treatment: a new hypothesis or just an accident?
Dzugan SA, Arnold Smith R.
Source – North Central Mississippi Regional Cancer Center, Greenwood, Mississippi 38935-0549, USA. sdzugan@tecinfo.com

Ann Agric Environ Med. 2014 Mar 31;21(1):156-60.
Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness , body composition and lipoprotein profile in middle-aged men.
Zając A1, Wilk M2, Socha T3, Maszczyk A4, Chycki J2.

cholesterol reducing drugsCholesterol reducing drugs are huge sellers for the drug industry, but are they safe? Cholesterol reducing drugs or cholesterol meds as they are referred to artificially lower cholesterol.

High cholesterol medication may not effectively prevent heart disease, and each new cholesterol drug seems to have it’s share of dangerous side effects.

Mainstream medicine’s reliance on medication for bringing down high cholesterol levels may very well be unfounded. Funding for research studies into the effectiveness of these drugs is often conducted by the very companies that stand to profit if the drug is approved. This is a huge conflict of interest, and it may even mean that the claims made for the effectiveness of cholesterol lowering medication are exaggerated or false.

The most popular class of cholesterol reducing drugs are called statins. They are taken by more than 25 million people around the world to lower cholesterol. In fact, the statin drug called Lipitor is the most widely prescribed drug in the world!

Some of the brand names of these statins are:

  • Lipitor
  • Pravachol
  • Vytorin
  • Zocor
  • Crestor

These drugs and many other cholesterol meds work by inhibiting an enzyme called HMG-CoA reductase, that is responsible for the production of cholesterol your liver. These drugs actually replace the HMG-CoA in your liver, which triggers the production of what are called LDL receptors, which attach to the cholesterol molecules and transport them to the liver where they are deactivated.

The problem with using these drugs to lower your cholesterol levels is twofold:

  • They are toxic and damage your liver
  • Your body actually needs cholesterol for many important biochemical reactions

Thus lowering your cholesterol by interfering with the production of this vital substance in your body is a dangerous practice that an increasing number of doctors feel is not worth the risk of side effects that these Cholesterol reducing drugs cause.

Statins contained in medicine to lower cholesterol, deplete a substance in your body called coenzyme q-10 which is used in many vital chemical processes in the body. One drug company was even working on a synthetic form of coenzyme q-10 that would be part of their cholesterol medicine, in order to prevent deficiencies of q-10 from causing side effects in the people taking their statin drugs.

However this product containing supplementary coenzyme q-10 never made it to commercial production. So when people take statins, they become deficient in this critical nutrient, and are not even aware they are at risk for some serious problems such as cancer, cardio myopathy, and Alzheimer’s disease, to name a few.

It goes without saying that anyone taking medicine to lower cholesterol should be taking supplementary coenzyme q-10 to protect themselves from deficiency cause by statin drugs.

Some health experts feel that the increases in cases of cancer, Alzheimer’s disease, rhabdomylosis (a medical condition that causes muscle breakdown), are due to the widespread use of cholesterol reducing drugs containing statins. Some doctors continue to aggressively promote and prescribe these drugs to their patients.

However other physicians, alarmed at the side effects of statins they are seeing, believe that the risks of these drugs are so great that their use in supposedly preventing heart disease is not justified.

Some of the warning signs of serious side effects are:

  • Persistent muscle pain
  • Numbness in fingers and toes
  • Loss of memory
  • Headache
  • Weakness or lack of energy
  • Rashes
  • Dark colored urine

These are just some of the signs that you are experiencing potentially serious side effects from a new cholesterol drug you are taking. These symptoms should be reported to your doctor right away. If the doctor you are seeing does not take them seriously or seem concerned, you should change doctors.

Cholesterol reducing drugs can have deadly side effects. It is best to pursue ways to lower cholesterol without dangerous drugs. Seek out a doctor that is knowledgeable about nutrition and natural ways to lower cholesterol. It just may save your life!

Green Tea and Cholesterol have been the subject of many research studies that indicate that it a highly beneficial substance for its ability to lower cholesterol naturally, and also provide antioxidant protection to your entire body!

cup of green teaThis age old herbal wonder has been used as a folk remedy for many different conditions in Asia, and has now become popular all over the world as a health sustaining drink.

Drinking tea can be a very healthy habit to get into IF you are drinking the right kind of tea.

What are the benefits for managing cholesterol levels?

Studies have shown that green tea and cholesterol have an inverse relationship, that is higher consumption of green tea results in lower cholesterol levels. Keep in mind that high chlesterol levels are often the body’s way of compensating for deficiencies (like vitamin-d for example), so when a substance seems to lower cholesterol levels it may indicate the body needs that substance to be healthy.

Here is a short list of benefits:

  •     Lower triglycerides
  •     Lower LDL cholesterol
  •     Raise HDL Cholesterol
  •     Boost antioxidant activity
  •     Lower inflammation
  •     Boosts levels of the super antioxidant SOD
  •     Lower risk of heart disease, high blood pressure, and cancer

Lower triglycerides

Green tea can lower triglycerides which in turn will lower LDL cholesterol. This effect on blood fats has been well documented. In addition the antioxidant benefits prevent LDL particles from oxidizing and this is very important for avoiding the artery damage that causes heart attacks.

Lower LDL cholesterol

LDL or “low density lipoproteins” are a big risk factor for cardiovascular disease. Green tea effectively lowers the levels of LDL in your body, removing a serious risk factor for the causation of arterial plaque, heart attacks, and strokes.

Raise HDL cholesterol

By raising HDL levels, green tea further protects arteries from damage caused by oxidized LDL. HDL itself is an antioxidants, and it has been shown that when several antioxidants combine in the body, they have a synergistic effect when combined.

Lower blood pressure

Green tea has a positive effect on blood pressure by promoting function of your arterial lining, which is what regulates blood pressure. This is preferable to the use of prescription drugs which can have serious side effects.

Research done in Japan on over 1,300 Japanese men indicated that green tea and cholesterol were inversely related, the more tea they consumed the more they were able to lower cholesterol naturally.  It can be part of a more natural approach to cholesterol mangement that avoids the serious side effects of using statins. This alone makes the tea worth serious consideration.

Those men who drank 9 cups per day or more had levels of cholesterol that were significantly lower than those drinking 0-2 cups per day. Tea drinking in Japan is a popular custom, and the Japanese are the longest living people in the world on average. While it’s true that the Japanese and Chinese do many healthy things diet and exercise wise, tea drinking is among the healthiest of them all.

Form and dosage

One to ten cups per day will provide benefits for your cardiovascular system, or you may find it more convenient to use in supplement form, consuming one (350-500mg) capsule per day of 95% extract of green tea.

Green tea and cholesterol will continue to be the subject of ongoing research, and it’s likely that this research will uncover even more benefits from using this age old herbal substance. One thing is for sure, and that is that you will get multiple health benefits by enjoying this age old Asian remedy!

What is Cholesterol

What is cholesterol? Among other things it is a very much misunderstood substance that people have been unnecessarily frightened of. They have been told repeatedly by “experts and authorities” that it’s a dangerous substance, that must be lowered in your body before it kills you!

what is cholesterolIn this information website, we will try and demystify this perfectly natural substance and disprove once and for all that it causes heart disease! We will also provide good solid information and easy to implement strategies that will help you prevent heart disease instead of just “lowering cholesterol.”

Let’s start with a discussion of  what is cholesterol…

Cholesterol is a fat (also called a lipid) that is made in the liver. It’s part of a class of compounds called steroids which are made in the bodies of all animals. This substance is vital to your body, is transported through the blood, and is contained in the external layers of all cells.

The origin of the word cholesterol originally comes from the word chole which means bile in Greek. The other part of the word derives from the Greek word stereos meaning stiff or solid. This waxy fatty substance is necessary for your cells to maintain their structural integrity.

This is why it is absolutely vital for life, and in fact your body actually manufactures this substance for use in all of your cells. Statin drugs interfere with the production of cholesterol which is why they cause so many side effects.

What is cholesterol used for?

There are many functions for this amazing substance:

  • It is used in creating the myelin that coats and protects your nerves somewhat like the insulation on a wire.
  • It is used for synthesizing bile acids which your body needs for digestion.
  • Your body uses it to make sex hormones (androgens and estrogens) and also in the synthesis of the adrenal hormones such as cortisol and aldosterone.
  • It’s used in to metabolize vitamins A, D, E, and K (the fat soluble vitamins)
  • It is used in the reactions that synthesize vitamin D from sunlight.
  • It’s essential for maintaining the outer structural layer of your cells and also for keeping the cell membranes permeable so that certain molecules can pass through the membrane and enter the cell.

In order to travel through your bloodstream, it needs to have a protein coating and thus becomes something called a “lipoprotein.” They are called lipoprotiens because they contain both protein and fat.

The four main types of these lipoproteins are:

  1. LDL or low density lipoproteins often called bad and are associated with an increased risk of heart disease when they are high
  2. Chylomicrons (triglycerides) consisting of approximately 90%  fat
  3. HDL or high density lipoproteins (often referred to as the “good cholesterol”) HDL is thought to “protect” the arteries from damage by carrying away LDL particles so they can’t build up on your artery walls.
  4. VLDL or very low-density lipoproteins (often referred to as a very bad form of lipoproteins) These particles are considered to have the highest risk of contributing to heart disease because they are small dense highly inflammatory particles that can damage artery walls.

The role of triglycerides…

Triglycerides are fat molecules that come from the fat in the foods we eat, or can be synthesized from carbohydrates that are not burned for energy. These triglycerides are stored in your body and released to be burned for energy when your body does not get enough food to meet it’s energy needs. The truth is that it is triglycerides that really increase the risk of heart disease!
Hypertriglyceridemia is a term used to refer to high levels of triglyceries in the blood and researchers now know that this is a risk factor for cardiovascular disease. High glycemic carbohydrates can raise levels of triglycerides and greatly increase risk of heart disease.

While this area is still somewhat controversial, it’s clear that triglycerides have a major role in heart disease and they are increased by sugar consumption. It makes sense for this reason to keep your intake of sugar and high glycemic carbohydrates low to avoid setting yourself up for cardiovascular disease.

A Complex Question…

Doctors have been taught to calculate your risk of heart disease using ratios of these lipoprotein particles. They have also been given guidelines for what the “safe” and “dangerous” levels are.  Now these guidelines have been called into question, as new information has changed what the medical community “thought” they knew!

Even though the question of  what is cholesterol is a complex one, you will see that terms like good  and bad cholesterol are misleading and inaccurate. All of these forms of this vital substance have their necessary roles. Instead we should be looking at the effects of chronic inflammation and how we can neutralize it, because it is really inflammation that causes heart disease!

References:

Curr Cardiol Rep. 2011 Dec;13(6):544-52. doi: 10.1007/s11886-011-0220-3.
The role of triglycerides in atherosclerosis. Talayero BG, Sacks FM.
Source: Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. btalayer@hsph.harvard.edu