artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

Natural hormone therapy for optimizing cholesterol has not yet gone mainstream in medicine, but it is going to be a popular new therapy in years to come. Bioidentical hormone therapy is a very safe and natural approach that will help people optimize cholesterol naturally and protect themselves from heart disease as they get older.

As you age, your hormonal systems begins to weaken, and that means that the amounts of critical hormones like, testosterone, DHEA, TSH, estrogen, and progesterone begin to decline. Since all of these hormones need to be in balance for your body to function properly, things begin to go wrong when one or more of these hormones decline, because then that delicate balance can no longer be maintained.

Medical science has slow to embrace natural hormone therapy for optimizing cholesterol , because this idea was considered radical due to misunderstanding by the scientific community. Recent studies have shown a strong correlation between declining hormones and higher cholesterol levels.

Clearly there is a link, and it appears as though restoring hormones to more youthful levels can normalize cholesterol quite effectively. This is logical because when you were younger and your hormone system was stronger and putting out higher levels of these critical hormones, your cholesterol levels were probably lower.

As you aged and your hormone system put out less and less of these hormones, your body was unable to maintain the healthier cholesterol profile your youth. It only makes sense that if you could go back to a more youthful hormone profile, you could significantly lower your risk of heart disease, and probably many other chronic diseases as well.

With that said, lets take a brief look at some research on natural hormone therapy for lowering cholesterol.

Why do declining hormones trigger increases in cholesterol levels?

The body uses cholesterol to make steroid hormones, and the theory is that when the levels of these hormones drop with age, the body tries to provide more cholesterol to the endocrine (hormonal) system to make hormones with.

To confirm this hypothesis, doctors Arnold Smith and Sergey Dzugan conducted a clinical research study on 41 patients with high cholesterol from 1997 to 2003. The results astounded them! In the study they replaced the hormones these patients were lacking, and all subjects experienced a significant drop in their blood cholesterol levels.

When using natural hormone therapy for optimizing cholesterol, it appeared that when normal hormone levels were restored, their bodies “down-regulated” (lowered output) of cholesterol from the liver. This suggests there is a mechanism whereby the body thinks the lower hormone levels are due to a lack of cholesterol, and so it increases it’s cholesterol production to give the body the “precursors” (necessary chemicals) to create these critical hormones.

Furthermore by lowering cholesterol “too much” we you could very well be preventing your body from synthesizing it’s critical hormones by limiting the cholesterol it needs to do it’s job. Nobody ever thinks about the fact that cholesterol is a vital and necessary substance, and that the only way you should go about trying to optimize it is by a natural process, not synthetic drugs.

Natural hormone therapy for lowering cholesterol is the correct approach because it takes into consideration how the body functions, and works with the body’s natural processes to lower cholesterol naturally.

The type of natural hormone therapy that I am speaking of is called bioidentical hormone therapy. It consists of a doctor doing blood and saliva testing on the patient to determine that baseline levels of all of the critical hormones, and then creating a prescription for the necessary hormones to be corrected. This is the principle behind natural hormone therapy.

This prescription is then processed by a compounding pharmacy using plant based hormones that are identical on the molecular level to what your own body produces. The dosages of these hormones the doctor prescribes are very precise and designed to get your critical hormone levels into the middle to high normal range.

This ensures that you only use just enough to create optimal health, and that any possible side effects are minimized or eliminated.

Natural hormone therapy for lowering cholesterol is one of the most effective and natural methods for lowering high cholesterol. It is backed by good scientific research and works WITH your body to safely lower cholesterol levels, rather than interfere with your body’s natural functions as statin drugs do.

References:

Med Hypotheses. 2002 Dec;59(6):751-6.
Hypercholesterolemia treatment: a new hypothesis or just an accident?
Dzugan SA, Arnold Smith R.
Source – North Central Mississippi Regional Cancer Center, Greenwood, Mississippi 38935-0549, USA. sdzugan@tecinfo.com

Ann Agric Environ Med. 2014 Mar 31;21(1):156-60.
Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness , body composition and lipoprotein profile in middle-aged men.
Zając A1, Wilk M2, Socha T3, Maszczyk A4, Chycki J2.

The PLAC test is a cutting edge medical screening test that identifies arterial The PLAC Testplaque that is in danger of rupturing. This test, used in conjunction with other cholesterol screening tests can pinpoint your risk of a sudden heart attack with a much greater degree of certainty.

The test actually measures levels of an enzyme in your blood known as lipoprotein phospholipase A2. This enzyme is responsible for a process that can cause damage to your endothelial layer and set the stage for atherosclerotic plaques which can rupture and trigger a heart attack.

When your levels of Lp-PLA2 are elevated, it indicates that you have plaque that can rupture and create a blood clot that results in a heart attack or stroke.

The most current information we have tells us that using cholesterol levels to determine your risk of heart attack is not very accurate. However medical science has identified a process where LDLs (low density lipoproteins) and Lp-PLA2 particles undergo oxidation by free radicals.

These oxidized particles then attack the blood vessel wall causing damage and making the plaque deposits hard and brittle. This oxidized brittle plaque can then break off and cause life threatening problems such as a heart attack or stroke.

Lp-PLA2 is actually created in atherosclerotic plaques and thus can serve as a marker for inflammation in the artery wall. People who have heart disease show high levels of this marker (Lp-PLA2) which not only indicates they have plaque buildup, but also that the plaque is oxidized and can cause severe cardiovascular events.

Autopsies on patients who died suddenly of heart attacks showed ruptured plaques and high levels of Lp-PLA2 in their arteries.

This has also been see in patients who undergo surgery for carotid artery atherosclerosis. They show the same high levels of Lp-PLA2 that indicates a danger of rupturing plaque.

Those people who showed atherosclerosis of the carotid artery but did not show symptoms had much lower levels of Lp_PLA2. It’s clear from this evidence that this is a very significant and useful marker for predicting sudden cardiovascular events.

Studies done at the May Clinic also found that Lp-PLA2 was a specific indicator of dangerous plaques even in the absence of other risk factors. This indicates that it is inflammation and not merely cholesterol levels that create the risk of sudden heart attacks and stokes, so it is inflammation that we should address in our efforts to prevent heart disease.

Advantages of the PLAC test:

  • The test more accurately predicts the risk of sudden heart attack or stroke than other lipid screening tests.
  • The test directly measure lipoprotein phospholipase levels, a very accurate inflammation marker.
  • The PLAC test is the only medical screening approved by the FDA that indicates both heart attack and stroke risk in patients.
  • The test is relatively inexpensive and convenient.
  • The test can also be used to monitor a patients response to treatment and lifestyle changes.
  • The test is covered by Medicare and private insurance companies.
  • The test does not have to be taken in a fasting state.
  • The test can be used in patients that are currently using Pravachol, Benadryl, and Tylenol

Who should get the PLAC test and when?

Experts recommend a formula for determining who should get the test based on other risk factors and their estimate risk of sudden heart attack within a ten year period. This makes no sense to me at all. We have a test that can specifically identify people who are a high risk for a heart attack or stroke, before this actually happens and give them a chance to lower their risk.

I believe the PLAC test should be used as a standard cardiovascular screen test, because it targets the process that is actually dangerous, rather than cholesterol levels which don’t really give an accurate measure of your risk. Once the test has been done, all that’s left is to determine how to go about lowering the risk, by reducing the inflammation in your arteries.

As to who should have it done, it makes sense to me that anyone approaching middle age would be a candidate for it. Autopsies of US soldiers killed during the Korean War showed atherosclerotic plaques in the arteries of young men in their 20’s. Based on this it seems reasonable that the test could even be done on people in their early 20’s as a way of identifying people who may be at risk and giving them plenty of time to make the lifestyle changes needed to protect themselves.

People with metabolic syndrome which consists of the following:

  • obesity
  • abnormal blood lipid profile
  • elevated blood sugar
  • high blood pressure

are prime candidates for the PLAC test, as it is known that metabolic syndrome involves inflammation and thus raises the risk of heart disease.

The test can be done at followup intervals to verify the success of lifestyle changes and other interventions in terms of lowering the patient’s risk. While I claim no medical expertise, common sense suggests that this test be done early and the person then adapt their lifestyle, nutritional and exercise habits to mitigate this risk. That approach makes the most sense.

How to interpret the test results:

Even though the Lp-PLA2 test is much different than cholesterol screening tests, the levels are somewhat similar:

The 3 risk levels are:

Low:   under 200 ng/mL

Borderline:  200 to 235 ng/mL

High:  over 235 ng/mL.

Lp-PLA2 levels over 200 to 220 ng/mL indicate a very high risk of endothelial damage which in turn presents a very high risk of atherosclerosis.

Medical Interventions:

The PLAC test can be used to identify the magnitude of risk and also to determine how well the treatments used to combat it are working. This is why followup tests are important.

Statin drugs are said to provide a 20-30% reduction in Lp-PLA2 levels. The risk to benefit ration of statins is something you will have to discuss with your doctor.

Niacin used in combination with statins is reported to provide an additional 5 to 20% further reduction of the Lp-PLA2 enzyme.

Angiotensin-converting enzyme (ACE) inhibitors are also reported to lower Lp-PLA2 levels, and medical scientists have speculated that the effectiveness of all cardiovascular drugs may actually depend on their ability to successfully lower Lp-PLA2 levels

Niacin and omega 3 fatty acids (fish oil) also show an ability to reduce levels of Lp-PLA2.

Tumeric spice (also called circumin) has been found to reduce a form of phospholipase in animals, and thus may be of value to humans in reducing Lp-PLA2 levels, but the study results are not in on this yet. My guess is however that turmeric is most probably of value in human as well.

Conclusion:

Since heart disease is the nation’s number one killer, preventing it is vitally important to a long and health life. Medical screening tests such as blood pressure and cholesterol are not enough to accurately predict who is a risk for a heart attack or stroke.

The PLAC test is relatively inexpensive, non invasive, and very accurate in predicting who is at high risk for a sudden cardiac event like a heart attack or stroke. It really represents a cutting edge approach to identifying people at high risk and helping them make the changes that can save their lives.

Eggs and Cholesterol – A Pervasive Nutritional Myth!

Many people have heard dire warnings about eggs and cholesterol, but is there any truth to this widely held belief at all? The answer is NO! Eggs have not been shown to significantly raise LDL (low density lipoproteins) levels when eaten in moderation. In fact eggs are actually be considered beneficial  when cooked and eaten properly and in moderate amounts.

eggs and cholesterol

Please note that the term LDL refers to the form considered by cardiologists to be “bad,”  however we will show in other posts that the idea of good and bad cholesterol is a misapplication of the science!.

Lipoproteins are another term for cholesterol. Thus HDL cholesterol is high density lipoproteins, and LDL is used  to refer to “low density lipoprotein.” The type that is believed by scientists to actually cause problems is called vldl cholesterol, (very low density lipoproteins). However even in this case the truth is more complicated than this and we will explain this as we go along.

The Facts about Eggs…

The fact is that egg yolks also contain lecithin which is a phosopholipid compound that actually lowers the amount your body absorbs. Thus the cholesterol in an egg does not have the same effect in your body, that it does when it comes from other sources.

Eggs contain about 185 milligrams of cholesterol (for a large egg), but they are also high in vitamin-d, choline (a b-vitamin) and lecithin. Interestingly, the saturated fat content in eggs is low. Research studies have shown that foods that you eat, does not have necessarily cause high cholesterol levels in your body, and in some cases may actually lower it!

It appears that the eggs and cholesterol myth began when the concern over lipoprotein levels being a factor in heart disease emerged. Researchers jumped to conclusions and people were warned that eggs greatly increased the risk of heart disease, based on this assumption, (based on poorly done research).

Eggs are Essential Sources of Choline

One negative result of this eggs and cholesterol hysteria was that people stopped eating eggs, or at least significantly cut down on egg consumption. The b-vitamin choline is essential to good health, especially of the brain.

The most abundant source of this vitamin in most people’s diets came from eggs. As a result the population as a whole became deficient in choline, leading to other serious health problems like Alzheimer’s Disease, and even increased rates of heart disease!

Choline is vital to the healthy function of the brain and nervous system, which in turn has a huge impact on heart health. Thus by limiting egg consumption and producing deficiency of choline in the diet, people were actually making the situation with regard to heart disease even worse!

What The Research Says…

Some people who have a genetic tendency toward higher levels called (familial hypercholesterolemia) may be affected by the amount they consume in their foods, but the mechanism is not totally clear. In fact the famous Framingham Study of heart disease shows that people with the highest hdl cholesterol levels actually lived the longest!

Recent research conducted on eggs and cholesterol at the University of Surrey by Dr. Bruce Griffin found that two eggs per day consumed by healthy people for a 12 week period actually lowered their LDL levels on average! It was concluded that eggs will not significantly raise cholesterol numbers in a healthy person. In this instance eggs actually lowered their levels!

In face the research subjects in the experimental group actually lost weight as well. This may seem surprising, but in light of the fact that egg yolks contains beneficial vitamins and high quality protein, it supplies your body with vital nutrients, without which you can’t achieve optimal health.

Recent research has also suggested that eggs may act in a way to reduce high blood pressure and that they contain antioxidants that help prevent heart disease. While this evidence is not yet conclusive, it suggests that eggs, far from being dangerous to our health are actually beneficial in preventing both cancer and heart disease!

Nutritional myths about eggs and cholesterol still persist in medicine and are accepted by the public at large, but gradually the word is getting out that eggs are not a bad food at all, in fact you need the beneficial nutrients in eggs for good health, including heart health!

References:

Chamila Nimalaratne, Daise Lopes-Lutz, Andreas Schieber, Jianping Wu. Free aromatic amino acids in egg yolk show antioxidant properties. Food Chemistry, 2011; 129 (1): 155 DOI:
Majumder et al. Angiotensin I Converting Enzyme Inhibitory Peptides from Simulated in Vitro Gastrointestinal Digestion of Cooked Eggs. Journal of Agricultural and Food Chemistry, 2009; 57 (2): 471 DOI: