artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

New cholesterol guidelines are being driven by drug company profits and promoted through the concept of “family history” or familial hypercholesterolemia! But what is the truth about heart disease and the alledged protective effect of statins?

Do these drugs protect aginst heart attacks and extend lifespans or is tghe truth about their effectiness compromised by faulty scientific studies paid for by the same companies that want to market these drugs as life savers?

This analysis by Drt. David Newman sheds light on the problems with studies called “meta-analysis” and how the results of these studies may mislead even doctors as to the safety and effectivenss of statin drugs for their cardiac patients.

The Diet-Heart Myth: Statins Don’t Save Lives in People …

http://chriskresser.com/ Mon, 13 May 2013 08:00:00 -0700

An analysis by Dr. David Newman in 2010 which drew on large meta-analyses of statins found that among those with pre-existing heart disease that took statins for 5 years (1): ….. Certainly I have a few older female patients who had chronic high LDL and LDL-P with family history even, but no other risk factors I could see, where I tested them up and down for evidence of vascular disease (they were concerned with being a walking time bomb) and found NONE – no …

Read more …

Citrus BergamotCitrus Bergamot is the latest natural supplement for lowering cholesterol levels and can also lower blood sugar as well. This new food supplement has taken the medical world by storm, even being used in place of statin drugs in some cases.

Truth be known, it’s an interesting compound but has many varied effects. It’s ability to block the synthesis of cholesterol means that it could cause problems in some people who’s cholesterol levels are too low to start with.

It is beneficial in other ways though, so it’s definitely something you need to discuss with an integrative cardiologist, if you are attempting to use it as a means of lowering cholesterol levels.

What is Citrus Bergamot?

Citrus Bergamot is a small sized tree that will blossom during winter. In terms of bitterness, it is less bitter than lemon but more than grapefruit. It is used as an ingredient in Earl Grey Tea. The juice of this plant is not consumed, but is used as a treatment for malaria, and the oil is used for aromatherapy.

A fragrant orange sized yellow green citrus fruit that is grown commercially in the Calabria region of Southern Italy. It is grown also in the southern part of France, as well as the south of Turkey.

The essential oil of Bergamot is a dark greenish-brown in color and is extracted in Cote d’Ivorie. It is grown in Antalya Turkey for use in marmalade.

Unlike other citrus fruits, Bergamot has very large amounts of polyphenols. Two of those compounds Melitidin, and Brutieridin, block the synthesis of cholesterol in the liver in much the same way statin drugs do.

It also has a similar effect to grapefruit in that it can affect the way your body metabolizes various pharmaceutical drugs.

How does it work?

Bergemot reduces the amount of triglycerides and cholesterol you would ordinarily absorb through meals. It also reduces the biosynthesis of cholesterol in the body. It also helps glucose get into cells which is beneficial for diabetics.

It blocks the HMG CoA Reductase Enzyme, which is what statin drugs do. It contains substances called polyphenolic flavanoids that suppress cholesterol production in much the same way that statins do, but it works in a different way that does not seem to deplete coenzyme Q10.

There are three main modes of action:

  • Blocks the HMG CoA Reductase Enzyme
  • Works on insulin receptors to improve shuttling of glucose into cells
  • Blocks cholesterol absorption in the intestine similar to plant sterols

What are some of the benefits of Citrus Bergamot?

  • It promotes fat burning and improves blood sugar control. This helps combat obesity and promotes weight loss.
  • It combats arterial stiffness due to it’s effect on sugar metabolism, and the benefits of the flavinoids it contains.
  • Can reduces LDL and triglycerides and increase HDL cholesterol
  • Helps in lowering blood pressure
  • Bergamot shows anti-tumor action and may be effective in combating neuroblastoma and other metastic cancers
  • It demonstrates anti-inflammatory and antioxidant properties that improve endothelial function

How is Bergamot taken?

When used for it’s cholesterol lowering effect, it would be taken in capsule form at appropriate doses, and this is where things get tricky. The medical profession knows a lot about drugs and the dosages that should be given, but not very much about vitamins, nutraceuticals, and herbs.

Citrus Bergamot capsulesDosage recommendations for this supplement are anecdotal and not the result of carefully controlled trials and years of clinical case studies and experience. Great care should be taken with this supplement, as it does mimic the effects of statin drugs, and thus could have some of the same side effects.

Given this fact, I think it’s wise to seek the advice of a complementary physician, who has knowledge of alternative treatments.

In research conducted at the Scripps Integrated Medicine Conference in San Diego California, in January 2012, they used 1,000 milligrams per day and got an average reduction in total cholesterol levels of 29%, a 36% reduction in LDL, and increase HDL cholesterol by 40%!

Reductions in triglycerides of 30%, and blood glucose of 20% on average were also noted. From this result the researches concluded that Citrus Bergamot extract at a dosage of 1,000 milligrams per day was an effective substitute for statin drugs for lowering LDL cholesterol, and also treating metabolic syndrome.

In Summary:

Citrus Bergamot is an interesting compound with some powerful effects on cholesterol metabolism, blood sugar control, and metabolic syndrome. It has demonstrated anti-tumor effects as well. However due to it’s statin like mode of action, I would very strongly suggest that you use it ONLY under the direction of a doctor who is knowledgeable about alternative medicine.

The doctor can help you determine if it’s right for you, and if so, how to arrive at a safe and effective dosage.

Research references:

Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Fitoterapia. 2010 Sep;81(6):453-61. doi: 10.1016/j.fitote.2010.01.013. Epub 2010 Jan 20.
Neuropharmacology of the essential oil of bergamot.

Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8.
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.

Fitoterapia. 2014 Jun;95:83-92. doi: 10.1016/j.fitote.2014.02.009. Epub 2014 Mar 2.
Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models.

PLoS One. 2013 Apr 16;8(4):e61484. doi: 10.1371/journal.pone.0061484. Print 2013.
Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.

HDL cholesterol level is the most important factor in your cholesterol profile. The cholesterol hdl ratio is used to determine your risk of a heart attack or stroke. Low hdl means greater risk, and I will explain the reasons why.

hdl cholesterol levelThe effect of cholesterol on your heart health has been distorted by bad information over the years. This is because pharmaceutical companies want to sell statin drugs, so they influenced doctors to set up guidelines that call for proscribing these drugs for lowering cholesterol levels.

The drugs do not lower cholesterol naturally, they do it by interfering with your body’s natural production of lipids, which is unhealthy and dangerous. What makes cholesterol a problem in your arteries is inflammation and free radicals which oxidize the cholesterol and turn it into hard plaques. Hdl cholesterol prevents this process, and protects you against heart disease.

How to raise increase good cholesterol

We know that HDL cholesterol functions as an antioxidant in the body. This means that it will help prevent LDL cholesterol from turning into dangerous plaques inside your arteries. This is why the cholesterol HDL ratio can predict your risk of heart disease. The higher the HDL cholesterol levels, the lower your risk.

So just how do we increase good cholesterol? We do it by diet, exercise, and using certain nutritional supplements that help boost HDL  levels.

Let’s start with diet! Below are some foods that can help increase good cholesterol:

  • Fatty fish such as salmon, tuna, mackerel, sardines
  • Raw nuts and seeds like walnuts, pecans, almonds, and flaxseeds
  • Whole eggs (yes that’s right…they must be WHOLE eggs)
  • Onions
  • Fresh raw low glycemic vegetables – especially dark leafy greens
  • Oat bran
  • Alcohol – 1 or 2 drinks per day maximum

These foods work in a natural way by giving your body the raw materials such as essential fatty acids it needs to raise  HDL!

Nutritional Supplements

Nutritional supplements can also help you increase good cholesterol

  • Fish oil
  • Pantothenic acid (vitamin B-5)
  • niacin – (vitamin B-3)
  • Gugulipid
  • Coenzyme Q-10
  • Carnitine
  • Vitamin-C
  • Vitamin-D
  • Magnesium
  • Polycosanol
  • Vitamin E-complex
  • Alpha Lipoic Acid
  • N-Acetyl-Cysteine
  • CLA – conjugated linoleic acid

All of these supplements help increase HDL levels, however niacin (B-3) and calcium pantothenate (B-5) are the most effective, so you should focus on them first, and add others if needed.

Exercise to raise your HDL cholesterol level

The best form of exercise is some kind of internal training. This might be circuit weight training, kettlebells, bodyweight exercises, ect. The main principle is the workouts should be brief, intense, and make your heart and lungs work hard.

Naturally, if you are older, or not on good health, you should get clearance from your doctor before engaging in strenuous exercise. You should also work into an exercise program gradually so that your body gets used to it. Never jump right into an intense exercise program. Take time to build up your exercise capacity so that you don’t overdo it.

The PACE program by Dr. Al Sears is an excellent exercise system for this!

Just what are good HDL cholesterol levels?

Remember that the cholesterol HDL ratio is very important. That determines your risk of heart attack. The table below reflects the Amercian Heart Association guidelines:

American Heart Association Guidelines

Desirable Borderline Risk
High Risk
HDL
60 or higher
40 to 59
40 or less (men)
HDL
60 or higher
50 to 59
50 or less (women)

Action steps to raise for your HDL cholesterol level:

  • Get your cholesterol HDL ratio tested so you know what they are to start
  • Work in 3 15 minute sessions of circuit or interval training per week
  • Avoid refined foods if possible – stick to raw fruits and vegetables
  • Get plenty of healthy fats in your daily diet
  • Supplement with niacin (B-3) and calcium pantothenate (B-5) to raise HDL

Your HDL cholesterol level is one of the best predictive markers for heart disease that we know of. HDL cholesterol protects you against heart disease, stroke, cancer, and Alzheimer’s disease. Make it a point to get your HDL cholesterol levels checked, get them into the healthy range and keep them there. Your heart will thank you!

Natural hormone therapy for optimizing cholesterol has not yet gone mainstream in medicine, but it is going to be a popular new therapy in years to come. Bioidentical hormone therapy is a very safe and natural approach that will help people optimize cholesterol naturally and protect themselves from heart disease as they get older.

As you age, your hormonal systems begins to weaken, and that means that the amounts of critical hormones like, testosterone, DHEA, TSH, estrogen, and progesterone begin to decline. Since all of these hormones need to be in balance for your body to function properly, things begin to go wrong when one or more of these hormones decline, because then that delicate balance can no longer be maintained.

Medical science has slow to embrace natural hormone therapy for optimizing cholesterol , because this idea was considered radical due to misunderstanding by the scientific community. Recent studies have shown a strong correlation between declining hormones and higher cholesterol levels.

Clearly there is a link, and it appears as though restoring hormones to more youthful levels can normalize cholesterol quite effectively. This is logical because when you were younger and your hormone system was stronger and putting out higher levels of these critical hormones, your cholesterol levels were probably lower.

As you aged and your hormone system put out less and less of these hormones, your body was unable to maintain the healthier cholesterol profile your youth. It only makes sense that if you could go back to a more youthful hormone profile, you could significantly lower your risk of heart disease, and probably many other chronic diseases as well.

With that said, lets take a brief look at some research on natural hormone therapy for lowering cholesterol.

Why do declining hormones trigger increases in cholesterol levels?

The body uses cholesterol to make steroid hormones, and the theory is that when the levels of these hormones drop with age, the body tries to provide more cholesterol to the endocrine (hormonal) system to make hormones with.

To confirm this hypothesis, doctors Arnold Smith and Sergey Dzugan conducted a clinical research study on 41 patients with high cholesterol from 1997 to 2003. The results astounded them! In the study they replaced the hormones these patients were lacking, and all subjects experienced a significant drop in their blood cholesterol levels.

When using natural hormone therapy for optimizing cholesterol, it appeared that when normal hormone levels were restored, their bodies “down-regulated” (lowered output) of cholesterol from the liver. This suggests there is a mechanism whereby the body thinks the lower hormone levels are due to a lack of cholesterol, and so it increases it’s cholesterol production to give the body the “precursors” (necessary chemicals) to create these critical hormones.

Furthermore by lowering cholesterol “too much” we you could very well be preventing your body from synthesizing it’s critical hormones by limiting the cholesterol it needs to do it’s job. Nobody ever thinks about the fact that cholesterol is a vital and necessary substance, and that the only way you should go about trying to optimize it is by a natural process, not synthetic drugs.

Natural hormone therapy for lowering cholesterol is the correct approach because it takes into consideration how the body functions, and works with the body’s natural processes to lower cholesterol naturally.

The type of natural hormone therapy that I am speaking of is called bioidentical hormone therapy. It consists of a doctor doing blood and saliva testing on the patient to determine that baseline levels of all of the critical hormones, and then creating a prescription for the necessary hormones to be corrected. This is the principle behind natural hormone therapy.

This prescription is then processed by a compounding pharmacy using plant based hormones that are identical on the molecular level to what your own body produces. The dosages of these hormones the doctor prescribes are very precise and designed to get your critical hormone levels into the middle to high normal range.

This ensures that you only use just enough to create optimal health, and that any possible side effects are minimized or eliminated.

Natural hormone therapy for lowering cholesterol is one of the most effective and natural methods for lowering high cholesterol. It is backed by good scientific research and works WITH your body to safely lower cholesterol levels, rather than interfere with your body’s natural functions as statin drugs do.

References:

Med Hypotheses. 2002 Dec;59(6):751-6.
Hypercholesterolemia treatment: a new hypothesis or just an accident?
Dzugan SA, Arnold Smith R.
Source – North Central Mississippi Regional Cancer Center, Greenwood, Mississippi 38935-0549, USA. sdzugan@tecinfo.com

Ann Agric Environ Med. 2014 Mar 31;21(1):156-60.
Effects of growth hormone and testosterone therapy on aerobic and anaerobic fitness , body composition and lipoprotein profile in middle-aged men.
Zając A1, Wilk M2, Socha T3, Maszczyk A4, Chycki J2.

Normal cholesterol levels…just what are they?  This is hard to determine because what is normal for one person is not normal for another. There is only a range where experts generally agree the risk of heart disease either increases or decreases when your cholesterol level falls outside of that range.

That’s about the best modern medicine can do, because of the many other factors involved in heart disease, and the fact that there is really no “normal level” just a normal cholesterol range.

The following table will help define what normal cholesterol levels are said to be by the American Heart Association:

American Heart Association Guidelines
Desirable Borderline Risk
High Risk
Total Cholesterol
200 or less
200-239
240 and over
HDL
60 or higher
40 to 59
40 or less (men)
HDL
60 or higher
50 to 59
50 or less (women)
LDL
less than 100
130-159
160-189
Triglycerides
less than 150
150-199
200-499

Normal Cholesterol Range and Hear Disease Risk

Keep in mind that these so called normal cholesterol levels are not absolutes, they are statistical representations of risk based on data that has been accumulated from studies and patient populations. What that all means is that they are scientific guesses!

Also bear in mind that the pharmaceutical industry CAN and DOES influence guidelines for normal cholesterol levels and risk factors, because it is to their advantage to do so. When the guidelines lower the threshold at which a person is said to be “at risk” more drugs are prescribed by doctors based on those guidelines.

This is very good for the drug companies because it boosts their sales of statin drugs, but it is NOT so good for patients, because they are being given drugs with toxic side effects based on an assessed “risk” that has been influenced by the companies that make the drugs.

So use the normal cholesterol levels in the above chart as just a guide, and focus on lowering cholesterol naturally, as well as inflammation. When you use natural methods, your body will normalize it’s cholesterol levels to what is appropriate for YOU.

You will be much healthier for it and will avoid toxic medications. These drugs can themselves create life threatening side effects which may be as bad or worse than the medical condition they are supposed to prevent.

Normal Cholesterol Levels vs HDL Ratio

The chart above also references what we call the HDL/LDL ratio. This is the ratio of the so called “good cholesterol” vs the “bad cholesterol.” This ration is actually more important as a risk factor than the total cholesterol level, because HDL is said to protect against heart disease.

There are many ways to raise HDL levels which when you think about it may also raise your total cholesterol level. However remember that the higher the HDL level, the less chance of heart disease, so raising HDL is something you definitely want to do.

Some of the strategies I will show you in this blog will both lower LDL and raise HDL. So DO think about this in terms of achieving this healthy ratio, rather than getting hung up on just the total cholesterol numbers, and what normal cholesterol levels are supposed to be. Remember that this ratio is more important than just being in the normal cholesterol range.

Cholesterol production vs serum cholesterol

Serum cholesterol is the amount of cholesterol detected in your blood. Your body actually makes cholesterol, which is a perfectly normal and natural function. Unless you have a genetic defect, it won’t make too much cholesterol.

Your focus when achieve a normal cholesterol level should be diet, exercise, and nutritional supplements! Statin drugs prevent your body from making cholesterol which is a dangerous thing to do.

The correct way to achieve so called normal cholesterol levels is making sure your body has low levels of inflammation, and helping your body clear excess cholesterol from your system, rather than allowing it to be cycled back into your bloodstream again.

cholesterol reducing drugsCholesterol reducing drugs are huge sellers for the drug industry, but are they safe? Cholesterol reducing drugs or cholesterol meds as they are referred to artificially lower cholesterol.

High cholesterol medication may not effectively prevent heart disease, and each new cholesterol drug seems to have it’s share of dangerous side effects.

Mainstream medicine’s reliance on medication for bringing down high cholesterol levels may very well be unfounded. Funding for research studies into the effectiveness of these drugs is often conducted by the very companies that stand to profit if the drug is approved. This is a huge conflict of interest, and it may even mean that the claims made for the effectiveness of cholesterol lowering medication are exaggerated or false.

The most popular class of cholesterol reducing drugs are called statins. They are taken by more than 25 million people around the world to lower cholesterol. In fact, the statin drug called Lipitor is the most widely prescribed drug in the world!

Some of the brand names of these statins are:

  • Lipitor
  • Pravachol
  • Vytorin
  • Zocor
  • Crestor

These drugs and many other cholesterol meds work by inhibiting an enzyme called HMG-CoA reductase, that is responsible for the production of cholesterol your liver. These drugs actually replace the HMG-CoA in your liver, which triggers the production of what are called LDL receptors, which attach to the cholesterol molecules and transport them to the liver where they are deactivated.

The problem with using these drugs to lower your cholesterol levels is twofold:

  • They are toxic and damage your liver
  • Your body actually needs cholesterol for many important biochemical reactions

Thus lowering your cholesterol by interfering with the production of this vital substance in your body is a dangerous practice that an increasing number of doctors feel is not worth the risk of side effects that these Cholesterol reducing drugs cause.

Statins contained in medicine to lower cholesterol, deplete a substance in your body called coenzyme q-10 which is used in many vital chemical processes in the body. One drug company was even working on a synthetic form of coenzyme q-10 that would be part of their cholesterol medicine, in order to prevent deficiencies of q-10 from causing side effects in the people taking their statin drugs.

However this product containing supplementary coenzyme q-10 never made it to commercial production. So when people take statins, they become deficient in this critical nutrient, and are not even aware they are at risk for some serious problems such as cancer, cardio myopathy, and Alzheimer’s disease, to name a few.

It goes without saying that anyone taking medicine to lower cholesterol should be taking supplementary coenzyme q-10 to protect themselves from deficiency cause by statin drugs.

Some health experts feel that the increases in cases of cancer, Alzheimer’s disease, rhabdomylosis (a medical condition that causes muscle breakdown), are due to the widespread use of cholesterol reducing drugs containing statins. Some doctors continue to aggressively promote and prescribe these drugs to their patients.

However other physicians, alarmed at the side effects of statins they are seeing, believe that the risks of these drugs are so great that their use in supposedly preventing heart disease is not justified.

Some of the warning signs of serious side effects are:

  • Persistent muscle pain
  • Numbness in fingers and toes
  • Loss of memory
  • Headache
  • Weakness or lack of energy
  • Rashes
  • Dark colored urine

These are just some of the signs that you are experiencing potentially serious side effects from a new cholesterol drug you are taking. These symptoms should be reported to your doctor right away. If the doctor you are seeing does not take them seriously or seem concerned, you should change doctors.

Cholesterol reducing drugs can have deadly side effects. It is best to pursue ways to lower cholesterol without dangerous drugs. Seek out a doctor that is knowledgeable about nutrition and natural ways to lower cholesterol. It just may save your life!

The PLAC test is a cutting edge medical screening test that identifies arterial The PLAC Testplaque that is in danger of rupturing. This test, used in conjunction with other cholesterol screening tests can pinpoint your risk of a sudden heart attack with a much greater degree of certainty.

The test actually measures levels of an enzyme in your blood known as lipoprotein phospholipase A2. This enzyme is responsible for a process that can cause damage to your endothelial layer and set the stage for atherosclerotic plaques which can rupture and trigger a heart attack.

When your levels of Lp-PLA2 are elevated, it indicates that you have plaque that can rupture and create a blood clot that results in a heart attack or stroke.

The most current information we have tells us that using cholesterol levels to determine your risk of heart attack is not very accurate. However medical science has identified a process where LDLs (low density lipoproteins) and Lp-PLA2 particles undergo oxidation by free radicals.

These oxidized particles then attack the blood vessel wall causing damage and making the plaque deposits hard and brittle. This oxidized brittle plaque can then break off and cause life threatening problems such as a heart attack or stroke.

Lp-PLA2 is actually created in atherosclerotic plaques and thus can serve as a marker for inflammation in the artery wall. People who have heart disease show high levels of this marker (Lp-PLA2) which not only indicates they have plaque buildup, but also that the plaque is oxidized and can cause severe cardiovascular events.

Autopsies on patients who died suddenly of heart attacks showed ruptured plaques and high levels of Lp-PLA2 in their arteries.

This has also been see in patients who undergo surgery for carotid artery atherosclerosis. They show the same high levels of Lp-PLA2 that indicates a danger of rupturing plaque.

Those people who showed atherosclerosis of the carotid artery but did not show symptoms had much lower levels of Lp_PLA2. It’s clear from this evidence that this is a very significant and useful marker for predicting sudden cardiovascular events.

Studies done at the May Clinic also found that Lp-PLA2 was a specific indicator of dangerous plaques even in the absence of other risk factors. This indicates that it is inflammation and not merely cholesterol levels that create the risk of sudden heart attacks and stokes, so it is inflammation that we should address in our efforts to prevent heart disease.

Advantages of the PLAC test:

  • The test more accurately predicts the risk of sudden heart attack or stroke than other lipid screening tests.
  • The test directly measure lipoprotein phospholipase levels, a very accurate inflammation marker.
  • The PLAC test is the only medical screening approved by the FDA that indicates both heart attack and stroke risk in patients.
  • The test is relatively inexpensive and convenient.
  • The test can also be used to monitor a patients response to treatment and lifestyle changes.
  • The test is covered by Medicare and private insurance companies.
  • The test does not have to be taken in a fasting state.
  • The test can be used in patients that are currently using Pravachol, Benadryl, and Tylenol

Who should get the PLAC test and when?

Experts recommend a formula for determining who should get the test based on other risk factors and their estimate risk of sudden heart attack within a ten year period. This makes no sense to me at all. We have a test that can specifically identify people who are a high risk for a heart attack or stroke, before this actually happens and give them a chance to lower their risk.

I believe the PLAC test should be used as a standard cardiovascular screen test, because it targets the process that is actually dangerous, rather than cholesterol levels which don’t really give an accurate measure of your risk. Once the test has been done, all that’s left is to determine how to go about lowering the risk, by reducing the inflammation in your arteries.

As to who should have it done, it makes sense to me that anyone approaching middle age would be a candidate for it. Autopsies of US soldiers killed during the Korean War showed atherosclerotic plaques in the arteries of young men in their 20’s. Based on this it seems reasonable that the test could even be done on people in their early 20’s as a way of identifying people who may be at risk and giving them plenty of time to make the lifestyle changes needed to protect themselves.

People with metabolic syndrome which consists of the following:

  • obesity
  • abnormal blood lipid profile
  • elevated blood sugar
  • high blood pressure

are prime candidates for the PLAC test, as it is known that metabolic syndrome involves inflammation and thus raises the risk of heart disease.

The test can be done at followup intervals to verify the success of lifestyle changes and other interventions in terms of lowering the patient’s risk. While I claim no medical expertise, common sense suggests that this test be done early and the person then adapt their lifestyle, nutritional and exercise habits to mitigate this risk. That approach makes the most sense.

How to interpret the test results:

Even though the Lp-PLA2 test is much different than cholesterol screening tests, the levels are somewhat similar:

The 3 risk levels are:

Low:   under 200 ng/mL

Borderline:  200 to 235 ng/mL

High:  over 235 ng/mL.

Lp-PLA2 levels over 200 to 220 ng/mL indicate a very high risk of endothelial damage which in turn presents a very high risk of atherosclerosis.

Medical Interventions:

The PLAC test can be used to identify the magnitude of risk and also to determine how well the treatments used to combat it are working. This is why followup tests are important.

Statin drugs are said to provide a 20-30% reduction in Lp-PLA2 levels. The risk to benefit ration of statins is something you will have to discuss with your doctor.

Niacin used in combination with statins is reported to provide an additional 5 to 20% further reduction of the Lp-PLA2 enzyme.

Angiotensin-converting enzyme (ACE) inhibitors are also reported to lower Lp-PLA2 levels, and medical scientists have speculated that the effectiveness of all cardiovascular drugs may actually depend on their ability to successfully lower Lp-PLA2 levels

Niacin and omega 3 fatty acids (fish oil) also show an ability to reduce levels of Lp-PLA2.

Tumeric spice (also called circumin) has been found to reduce a form of phospholipase in animals, and thus may be of value to humans in reducing Lp-PLA2 levels, but the study results are not in on this yet. My guess is however that turmeric is most probably of value in human as well.

Conclusion:

Since heart disease is the nation’s number one killer, preventing it is vitally important to a long and health life. Medical screening tests such as blood pressure and cholesterol are not enough to accurately predict who is a risk for a heart attack or stroke.

The PLAC test is relatively inexpensive, non invasive, and very accurate in predicting who is at high risk for a sudden cardiac event like a heart attack or stroke. It really represents a cutting edge approach to identifying people at high risk and helping them make the changes that can save their lives.

Cholesterol too low, how can this be a problem? We have all heard about the supposed relationship of heart disease to cholesterol levels, so we assume that lower is better. NOT SO!

cholesterol too lowEverything in your body is based on maintaining a balance, and cholesterol profiles are no exception.  Low cholesterol levels can be just as unhealthy as levels that are too high.

The belief that simply lowering cholesterol will protect you from heart attacks has been encouraged by the pharmaceutical industry and those medical professionals that serve it.  While cholesterol is a factor, there are other things involved such as inflammation, that make a big difference.

The risks of various serious medical conditions rise for those individuals having a total cholesterol level of under 160 mg/dl (milligrams per deciliter).  That said, some experts recommend that the ideal is somewhere between 180mg/dl and 200mg/dl for total cholesterol, (but even this is subject to controversy)

What causes low cholesterol?

Cholesterol that’s too low can be caused by:

  • Use of statin drugs
  • Malnutrition
  • Malabsorption – inadequate absorption of nutrients from the intestines
  • Hyperthyroidism
  • Liver dysfunction
  • Manganese deficiency
  • Celiac disease
  • Leukemia and other blood diseases

Please note:  Excessively low cholesterol levels need to be evaluated by a trained medical professional to determine the cause and the proper treatment. It is important not only to know what causes low cholesterol, but also having a proper treatment strategy in place to make sure you address it.

When you optimize cholesterol naturally, this is not a problem, because you are not trying to curtail your own body’s production of cholesterol, but rather preventing re-absorption through the large intestine.

You will NOT bring your cholesterol too low with this approach.

Effects of low cholesterol

Hypocholesterolemia – cholesterol too low, has been associated with a number of serious medical disorders such as:

  • Reduced production of your body’s steroid hormones
  • Increased risk of cancer
  • Increased risk of heart disease
  • Increased risk of strokes
  • Increased risk of depression/bipolar disorder
  • Increase risk of Alzheimer’s disease
  • Loss of sex drive
  • Possible loss of memory
  • Increased risk of suicide
  • Increased risk of schizophrenia

Effects of low cholesterol are very serious, and you need to focus not on simply lowering cholesterol, but achieving a healthy level based on your individual biochemistry.  With cholesterol too low, many vital chemical processes can’t be completed properly.

Cholesterol too low? – So what is the right approach?

The correct approach is not to simply focus on lowering cholesterol, just as weight loss should not simply be about losing weight.  Rather than making your cholesterol too low, this process will allow you to achieve the right balance.

That process includes:

  • Proper eating
  • Proper exercise
  • Nutritional supplementation
  • Stress reduction

Proper eating should include foods that are low in cholesterol but also nutrient dense, and which contain plenty of fiber. This is because fiber can absorb excess cholesterol as it passes through the large intestine and is then excreted out of the body in the stool.  The recommended fiber consumption is about 25 grams per day for women and 38 grams per day for men.

Proper exercise is short and intense, like interval training, but ultimately should be moderated by the age and physical condition of the person doing it. Be cautious and seek professional guidance in setting up an exercise program if you are an older person, or if you have a serious medical condition.

Nutritional supplementation should include full spectrum vitamin and mineral formula. A high quality fish oil is also a key supplement that will lower your risk of heart disease and every other medical condition you can think of. Sufficient levels of omega 3 fatty acids are essential to good health, and fish oil supplies these.

Stress reduction uses various techniques to lower stress and promote relaxation and tranquility. Among these, grounding is one of the most effective. Other strategies like meditation, the speed trace, and various other relaxation techniques can be very effective.

Having your cholesterol too low is a risk factor for chronic disease. A balanced approach, rather than just low cholesterol levels is the answer. Doing the things mentioned above should allow you to naturally achieve the right balance.

Soluble fiber for cholesterol is another safe and healthy way to lower cholesterol naturally, which lowers your risk of heart disease. Using fiber to lower cholesterol is a safer alternative to toxic drugs, besides which foods high in fiber have many other health benefits.

soluble fiber for cholesterFoods high in fiber have an important function in your body, and help to lower your risk of several chronic health conditions. Such fiber rich foods should be included in your diet on a daily basis.

Soluble means that your body can break them down, as opposed to insoluble which means that they pass through your digestive system without being broken down.

What foods contain soluble fiber for cholesterol?

Here is a short list of foods high in fiber.

  •     Psyllium husks
  •     Peas, beans, lentils
  •     Oats, oat bran, wheat bran,
  •     Broccoli, carrots, squash, potatoes, Zucchini
  •     Apples, oranges, tangerines, plums, strawberries, blackberries, apricots

There are more comprehensive lists of foods high in fiber online, but the above list gives you an idea of common foods that you can include in your diet to lower cholesterol naturally.

How do foods high in fiber work?

Research studies have established a positive correlation between dietary fiber and lowered cholesterol levels. There are 3 mechanisms that possibly explain this lowering effect:

  • Preventing cholesterol to be re-absorbed from bile sales and causing more of it to be excreted by elimination (feces)
  • Lowered glycemic response and reduced stimulation of cholesterol synthesis in the liver
  • Fermentation effects of soluble fiber affect bile salts and cut down on re-absorption in a way that is not well understood by science

Excess cholesterol that is not used by the body to synthesize hormones or other important functions is combined with bile acids in your large intestine, is recycled through your liver, and ends up back in your bloodstream.

Foods high in fiber can bind with the cholesterol and help transport it out of your body when you move your bowels. This is part of the way that foods high in fiber can lower cholesterol naturally, rather than using statin drugs that have dangerous side effects.

Remember as well that these sources of fiber only work optimally when you are well hydrated. Water is essential to getting the maximum benefits from fiber on your diet, so make a point to consume plenty of clean pure water throughout the day.

Using fiber to lower cholesterol does work and has been shown to be effective in well conducted studies. The role of soluble fiber for cholesterol has been known for years, but the public has only recently been made aware of it’s benefits.

You could say that using soluble fiber for cholesterol is the most natural way to optimize your cholesterol levels and fiber has other health benefits as well as it’s effect on blood lipids. Better function of your gastrointestinal system (gut) improves health across the board, and fiber has been shown to be beneficial to improving levels of pro-biotic bacteria in the colon.

Daily Recommended Amounts

The USDA recommends 14 grams of fiber for every 1,000 calories consumed for healthy adults. This works out to about 25-30 grams of fiber per day. The average for adults in the United States is approximately 15 grams.

Increased intake of fiber to lower cholesterol has also been associated with a lower risk of cancer, stroke, Alzheimer’s disease, and diabetes, as well as heart disease. Foods high in fiber thus have many benefits beyond helping to optimize cholesterol levels.

Soluble fiber for cholesterol is one of the most important strategies for maintaining a healthy cholesterol profile. Try working these soluble fiber foods into your diet, and you will automatically lower your risk of heart disease!

Soluble fiber for cholesterol – scientific references:

Food Funct. 2010 Nov;1(2):149-55. doi: 10.1039/c0fo00080a. Epub 2010 Sep 30. Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides.
Gunness P, Gidley MJ.

Am J Clin Nutr. 1999 Jan;69(1):30-42. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Brown L, Rosner B, Willett WW, Sacks FM.