New cholesterol guidelines are being driven by drug company profits and promoted through the concept of “family history” or familial hypercholesterolemia! But what is the truth about heart disease and the alledged protective effect of statins?

Do these drugs protect aginst heart attacks and extend lifespans or is tghe truth about their effectiness compromised by faulty scientific studies paid for by the same companies that want to market these drugs as life savers?

This analysis by Drt. David Newman sheds light on the problems with studies called “meta-analysis” and how the results of these studies may mislead even doctors as to the safety and effectivenss of statin drugs for their cardiac patients.

The Diet-Heart Myth: Statins Don’t Save Lives in People …

http://chriskresser.com/ Mon, 13 May 2013 08:00:00 -0700

An analysis by Dr. David Newman in 2010 which drew on large meta-analyses of statins found that among those with pre-existing heart disease that took statins for 5 years (1): ….. Certainly I have a few older female patients who had chronic high LDL and LDL-P with family history even, but no other risk factors I could see, where I tested them up and down for evidence of vascular disease (they were concerned with being a walking time bomb) and found NONE – no …

Read more …

Normal cholesterol levels…just what are they?  This is hard to determine because what is normal for one person is not normal for another. There is only a range where experts generally agree the risk of heart disease either increases or decreases when your cholesterol level falls outside of that range.

That’s about the best modern medicine can do, because of the many other factors involved in heart disease, and the fact that there is really no “normal level” just a normal cholesterol range.

The following table will help define what normal cholesterol levels are said to be by the American Heart Association:

American Heart Association Guidelines
Desirable Borderline Risk
High Risk
Total Cholesterol
200 or less
200-239
240 and over
HDL
60 or higher
40 to 59
40 or less (men)
HDL
60 or higher
50 to 59
50 or less (women)
LDL
less than 100
130-159
160-189
Triglycerides
less than 150
150-199
200-499

Normal Cholesterol Range and Hear Disease Risk

Keep in mind that these so called normal cholesterol levels are not absolutes, they are statistical representations of risk based on data that has been accumulated from studies and patient populations. What that all means is that they are scientific guesses!

Also bear in mind that the pharmaceutical industry CAN and DOES influence guidelines for normal cholesterol levels and risk factors, because it is to their advantage to do so. When the guidelines lower the threshold at which a person is said to be “at risk” more drugs are prescribed by doctors based on those guidelines.

This is very good for the drug companies because it boosts their sales of statin drugs, but it is NOT so good for patients, because they are being given drugs with toxic side effects based on an assessed “risk” that has been influenced by the companies that make the drugs.

So use the normal cholesterol levels in the above chart as just a guide, and focus on lowering cholesterol naturally, as well as inflammation. When you use natural methods, your body will normalize it’s cholesterol levels to what is appropriate for YOU.

You will be much healthier for it and will avoid toxic medications. These drugs can themselves create life threatening side effects which may be as bad or worse than the medical condition they are supposed to prevent.

Normal Cholesterol Levels vs HDL Ratio

The chart above also references what we call the HDL/LDL ratio. This is the ratio of the so called “good cholesterol” vs the “bad cholesterol.” This ration is actually more important as a risk factor than the total cholesterol level, because HDL is said to protect against heart disease.

There are many ways to raise HDL levels which when you think about it may also raise your total cholesterol level. However remember that the higher the HDL level, the less chance of heart disease, so raising HDL is something you definitely want to do.

Some of the strategies I will show you in this blog will both lower LDL and raise HDL. So DO think about this in terms of achieving this healthy ratio, rather than getting hung up on just the total cholesterol numbers, and what normal cholesterol levels are supposed to be. Remember that this ratio is more important than just being in the normal cholesterol range.

Cholesterol production vs serum cholesterol

Serum cholesterol is the amount of cholesterol detected in your blood. Your body actually makes cholesterol, which is a perfectly normal and natural function. Unless you have a genetic defect, it won’t make too much cholesterol.

Your focus when achieve a normal cholesterol level should be diet, exercise, and nutritional supplements! Statin drugs prevent your body from making cholesterol which is a dangerous thing to do.

The correct way to achieve so called normal cholesterol levels is making sure your body has low levels of inflammation, and helping your body clear excess cholesterol from your system, rather than allowing it to be cycled back into your bloodstream again.

The PLAC test is a cutting edge medical screening test that identifies arterial The PLAC Testplaque that is in danger of rupturing. This test, used in conjunction with other cholesterol screening tests can pinpoint your risk of a sudden heart attack with a much greater degree of certainty.

The test actually measures levels of an enzyme in your blood known as lipoprotein phospholipase A2. This enzyme is responsible for a process that can cause damage to your endothelial layer and set the stage for atherosclerotic plaques which can rupture and trigger a heart attack.

When your levels of Lp-PLA2 are elevated, it indicates that you have plaque that can rupture and create a blood clot that results in a heart attack or stroke.

The most current information we have tells us that using cholesterol levels to determine your risk of heart attack is not very accurate. However medical science has identified a process where LDLs (low density lipoproteins) and Lp-PLA2 particles undergo oxidation by free radicals.

These oxidized particles then attack the blood vessel wall causing damage and making the plaque deposits hard and brittle. This oxidized brittle plaque can then break off and cause life threatening problems such as a heart attack or stroke.

Lp-PLA2 is actually created in atherosclerotic plaques and thus can serve as a marker for inflammation in the artery wall. People who have heart disease show high levels of this marker (Lp-PLA2) which not only indicates they have plaque buildup, but also that the plaque is oxidized and can cause severe cardiovascular events.

Autopsies on patients who died suddenly of heart attacks showed ruptured plaques and high levels of Lp-PLA2 in their arteries.

This has also been see in patients who undergo surgery for carotid artery atherosclerosis. They show the same high levels of Lp-PLA2 that indicates a danger of rupturing plaque.

Those people who showed atherosclerosis of the carotid artery but did not show symptoms had much lower levels of Lp_PLA2. It’s clear from this evidence that this is a very significant and useful marker for predicting sudden cardiovascular events.

Studies done at the May Clinic also found that Lp-PLA2 was a specific indicator of dangerous plaques even in the absence of other risk factors. This indicates that it is inflammation and not merely cholesterol levels that create the risk of sudden heart attacks and stokes, so it is inflammation that we should address in our efforts to prevent heart disease.

Advantages of the PLAC test:

  • The test more accurately predicts the risk of sudden heart attack or stroke than other lipid screening tests.
  • The test directly measure lipoprotein phospholipase levels, a very accurate inflammation marker.
  • The PLAC test is the only medical screening approved by the FDA that indicates both heart attack and stroke risk in patients.
  • The test is relatively inexpensive and convenient.
  • The test can also be used to monitor a patients response to treatment and lifestyle changes.
  • The test is covered by Medicare and private insurance companies.
  • The test does not have to be taken in a fasting state.
  • The test can be used in patients that are currently using Pravachol, Benadryl, and Tylenol

Who should get the PLAC test and when?

Experts recommend a formula for determining who should get the test based on other risk factors and their estimate risk of sudden heart attack within a ten year period. This makes no sense to me at all. We have a test that can specifically identify people who are a high risk for a heart attack or stroke, before this actually happens and give them a chance to lower their risk.

I believe the PLAC test should be used as a standard cardiovascular screen test, because it targets the process that is actually dangerous, rather than cholesterol levels which don’t really give an accurate measure of your risk. Once the test has been done, all that’s left is to determine how to go about lowering the risk, by reducing the inflammation in your arteries.

As to who should have it done, it makes sense to me that anyone approaching middle age would be a candidate for it. Autopsies of US soldiers killed during the Korean War showed atherosclerotic plaques in the arteries of young men in their 20’s. Based on this it seems reasonable that the test could even be done on people in their early 20’s as a way of identifying people who may be at risk and giving them plenty of time to make the lifestyle changes needed to protect themselves.

People with metabolic syndrome which consists of the following:

  • obesity
  • abnormal blood lipid profile
  • elevated blood sugar
  • high blood pressure

are prime candidates for the PLAC test, as it is known that metabolic syndrome involves inflammation and thus raises the risk of heart disease.

The test can be done at followup intervals to verify the success of lifestyle changes and other interventions in terms of lowering the patient’s risk. While I claim no medical expertise, common sense suggests that this test be done early and the person then adapt their lifestyle, nutritional and exercise habits to mitigate this risk. That approach makes the most sense.

How to interpret the test results:

Even though the Lp-PLA2 test is much different than cholesterol screening tests, the levels are somewhat similar:

The 3 risk levels are:

Low:   under 200 ng/mL

Borderline:  200 to 235 ng/mL

High:  over 235 ng/mL.

Lp-PLA2 levels over 200 to 220 ng/mL indicate a very high risk of endothelial damage which in turn presents a very high risk of atherosclerosis.

Medical Interventions:

The PLAC test can be used to identify the magnitude of risk and also to determine how well the treatments used to combat it are working. This is why followup tests are important.

Statin drugs are said to provide a 20-30% reduction in Lp-PLA2 levels. The risk to benefit ration of statins is something you will have to discuss with your doctor.

Niacin used in combination with statins is reported to provide an additional 5 to 20% further reduction of the Lp-PLA2 enzyme.

Angiotensin-converting enzyme (ACE) inhibitors are also reported to lower Lp-PLA2 levels, and medical scientists have speculated that the effectiveness of all cardiovascular drugs may actually depend on their ability to successfully lower Lp-PLA2 levels

Niacin and omega 3 fatty acids (fish oil) also show an ability to reduce levels of Lp-PLA2.

Tumeric spice (also called circumin) has been found to reduce a form of phospholipase in animals, and thus may be of value to humans in reducing Lp-PLA2 levels, but the study results are not in on this yet. My guess is however that turmeric is most probably of value in human as well.

Conclusion:

Since heart disease is the nation’s number one killer, preventing it is vitally important to a long and health life. Medical screening tests such as blood pressure and cholesterol are not enough to accurately predict who is a risk for a heart attack or stroke.

The PLAC test is relatively inexpensive, non invasive, and very accurate in predicting who is at high risk for a sudden cardiac event like a heart attack or stroke. It really represents a cutting edge approach to identifying people at high risk and helping them make the changes that can save their lives.

A home cholesterol test is one way that you can begin taking more responsibility for your health, and understanding just how your diet and lifestyle affect your cholesterol values. A cholesterol blood test will determine if you have normal cholesterol levels, and if not, the cholesterol test results can be read and further interpreted by your doctor.

Testing in a home environment is just not as accurate as the tests performed in your doctor’s office. Home test kits are just not engineered to replace a full diagnostic lab, but they don’t have to. These tests are meant to help you keep track of your cholesterol values, and make adjustments to your diet and lifestyle when you need to.

Caution: Never substitute a home cholesterol test, or home testing (of any kind) for proper diagnosis and treatment from your doctor. Your physician can measure cholesterol levels much more precisely using lab tests that you can with a home test, so the lab work your doctor orders on your blood samples is the most accurate and best way to establish what your levels really are.

Home tests help you keep track of markers like cholesterol or blood sugar, but they are not meant to be substitutes for a proper medical test or diagnosis!

You need to be tested by your doctor to establish what is called a “baseline,” and once you know what this is, then home testing can tell you whether your levels are going up or down. These measurements are “relative” and their real value is helping you to track how your cholesterol levels are responding to diet and exercise.

Although the home cholesterol test is fairly accurate, it should be calibrated with the cholesterol blood test that you have in your doctor’s office. Take your home test kit with you and test yourself at the same time your doctor draws your blood for the full laboratory test.

That way you can see how the results of the two tests differ, and will be able to get an idea of just how far off the cholesterol test results are between the cholesterol blood test you get in the doctor’s office and the home cholesterol test.

When you buy online, read reviews carefully, do a little research into the product you are buying. Some of these cholesterol testing systems are expensive (over $100.00) dollars, require you to buy a testing unit, and additional test strips for it. This can run well over $100.00 for both.

Obviously you would not use a home cholesterol test as often as you would use a glucose monitor for instance. You are merely trying to track your normal cholesterol levels, and see how they respond to changes you make in your diet and lifestyle.

Here are some brands:

  •     CholesTrak, Home Access Instant Cholesterol Test
  •     Cardio Check (gives you both HDL and LDL level)
  •     Lifestream Personal Cholesterol Monitor (give you both HDL and LDL)

“Cardio Check” seemed to have by far the highest customer satisfaction ratings online.

A home cholesterol test should can run between $10.00 and $150.00 depending on how comprehensive the test is. Some tests only give you total cholesterol, which is not a very useful indicator. It may tell you how your total cholesterol levels is responding to diet or exercise, but it does not indicate real risk factors.

For that you need to know your HDL level, and a test that gives you both LDL and HDL levels will give you the information to assess risk factors more clearly. When you know both your LDL and HDL levels, you can calculate total cholesterol, as well as HDL/LDL ratio which is the best cholesterol values which indicate your heart disease risk.

The home cholesterol test to look for is one that at least gives you both HDL and LDL levels. These should run you about $30-$50 and are available online. Again you will have to check it for accuracy against the cholesterol blood test from your doctor, but if it gives you a somewhat reliable indicator of your cholesterol values, then it’s doing it’s job.

C-Reactive Protein  or CRP,  is what is called an inflammatory marker. It measures levels of a particular protein that indicate increased inflammation in your body. Along with homocysteine, it completes the picture of heart disease risk that begins with your cholesterol profile.

c-reactie proteinWhile optimizing your cholesterol profile is important, medical researchers noticed that half of all heart attack victims had normal cholesterol levels.

They realized that there were risk factors other than just cholesterol. This is where the c-reactive protein test comes in.

The test is a measure of inflammation and infection in your body, both of which are significant risk factors for heart disease that are largely ignored by mainstream medicine. Inflammatory markers like CRP are necessary in order to get an accurate idea of what your heart disease risk really is!

The test is part of that missing piece of the puzzle that explains heart disease risk, beyond just your cholesterol numbers. If your levels are high, then lowering them will definitely lessen your risk of heart disease. When you attempt to lower cholesterol naturally, you will have to pay attention to
CRP as well. The good news is that the same strategies will work for both!

What elevates CRP?

Your levels of c-reactive protein are elevated by increased inflammation in your body. Many things can cause this, so it is important to have the test done when you are feeling well and not suffering from illness or unusual stress, so that you can get an accurate reading of your levels, without
having the level elevated due to some injury, illness, or trauma.

For instance oral bacteria from dental cavities can elevate CRP levels, because those bacteria also cause inflammation. This is why dental health is correlated with heart disease risk. Bacterial infections of any kind will raise inflammation as your immune system attempts to fight off the bacteria.

What are healthy levels of c-reactive protein?

The CRP test measures results in milligrams per liter of blood.

The following guidelines for are recommended by the
American Heart Association (AHA) to determine heart disease risk:

  •     Low risk: CRP is 1 milligram/per liter or less
  •     Moderate risk: CRP is 1 to 3 milligrams/ per liter
  •     High risk: CRP is greater than 3 milligrams/ per liter

Lowering Inflammation

How do you lower inflammation and get the levels on the c-reactive protein test into the healthy range?  Since all these heart disease risk factors respond to the same lifestyle changes, you can address them all by doing a few simple things.

  •     Eating an “anti-inflammatory diet”
  •     Practice good oral hygiene
  •     Getting regular exercise
  •     Grounding
  •     Stress reduction
  •     Proper nutritional supplements

The Bottom Line

All of the various risk factors for heart disease may seem bewildering and overly technical. That is how medical science functions. Every factor must be measured and accounted for. The good part is that when you lower cholesterol naturally, you will be addressing these other factors as well.

However as I mentioned before, all of these factors are related, and they are just various manifestations of inflammation. Lowering inflammation will bring CRP and these other heart disease indicators to a better level. So that should be your goal, to use diet, exercise and nutritional supplementation in lowering inflammation.

C-reactive protein, homocysteine, and cholesterol profile are all necessary tests to precisely and accurately determine what your risk for heart disease really is. Work to lower your inflammatory markers, and you will be much healthier for it!

The VAP cholesterol test is the very latest diagnostic test to determine your risk of heart disease. Standard cholesterol level tests identify only 40% of those at risk for heart disease. In fact, half of all heart attacks are suffered by people with normal levels!

VAP cholesterol testProblems With Traditional Tests

One of the shortcomings of standard tests was that they didn’t measure or identify lipoprotein particles associated with increased inflammation.

Medical science has really caught on to the fact that it’s really the damage that inflammation does to your arteries that causes heart disease.

The old standard for testing was to measure LDL, HDL, and total cholesterol and to use the ratio between LDL and HDL to determine a person’s risk of heart disease. This was fairly accurate for it’s time, but it has been superseded by a new standard for determining your risk.

The old testing protocol produced four measurements:

  • Total cholesterol
  • Triglycerides
  • LDL – Low-density lipoprotein
  • HDL – High-density lipoprotein

Although these four elements do have some value in determining your risk of heart attack, they lack the accuracy of newer test methods in determining risk.

Enter the VAP Cholesterol Test

Medical science has recently developed a newer and more accurate test for heart disease risk called VAP  for (Vertical Auto Profile). This test benefits you in two ways.

  • It is THE most accurate indicator of your risk of heart attack
  • It helps identify various risk factors that you can control to prevent a heart attack

VAP cholesterol test can pinpoint your risk, taking much of the guesswork out of this medical diagnosis. This is very helpful for people who have test results that show normal levels, but who’s true heart attack risk can now be successfully identified.

Not all doctors provide the VAP cholesterol test, but it’s use is increasing as more and more doctors realize their standard testing fails to identify everyone that is at risk.

The VAP test is done the same way as other tests where a nurse or lab technician draws your blood and then sends it to a laboratory which then runs the test and returns the test results to your doctor.

How Does The Test Work?

The test identifies the following:

  • Identifies small dense LDL particles that cause arterial plaque
  • HDL2 and HDL3
  • IDL – Intermediate-density lipoprotein
  • Lipoprotein A
  • (VLDL1, VLDL2, VLDL3) Very low density lipoproteins

These small sub-fractions of cholesterol pose the greatest danger to you. The VAP cholesterol test will identify these particles, their density, and distribution. This information helps your doctor create a customized approach to reducing your risk of a heart attack and strokes.

Standard test results are still valuable as a screening method for heart disease. It is an inexpensive way of determining if you are at increased risk. The addition of the VAP test further clarifies your degree of risk and allows you to make needed lifestyle changes to head off a possible heart attack.

The key is to identify risks early while there is still time to reverse them with diet and exercise rather than drugs such as statins which have toxic side effects. The test really represents an advance in thinking that more accurately gauges how these individual lipoprotein particles affect your overall risk for heart disease.

The VAP cholesterol test will soon become the standard for determining your heart attack risk. This will go a long way toward making heart attacks increasingly rare and survivable! Ask YOUR doctor about the VAP test, and start reducing your risk now!