vitamin-d-sourcesFew people are aware of the relationship between vitamin d and cholesterol, but it’s an important one and it shouldn’t be ignored. Although it’s called a vitamin, it’s actually a hormone and a deficiency of it can be life threatening!

It’s Actually a Hormone

Vitamin d refers to a number of is a fat soluble steroid molecules that are involved in the absorption of important minerals in your intestinal tract.

The two most important factors are:
vitamin D3 (cholecalciferol) and vitamin D2 (ergocalciferol)

It’s also called the “sunshine vitamin” because it can be bio synthesized in your body when your skin is exposed to natural sunlight. This is especially important to people of African ancestry that live in temperate climates that have long winters.

Since their darker skin pigmentation filters out some of the suns rays, they are at increased risk of deficiency because of their skin filtering out natural sunlight (especially during long winters.)

For black people, supplements are a MUST! It appears that pretty much every disease that people of African descent suffer from disproportionately is linked with vitamin d deficiency. This is not widely known, but can still cause lots of health problems that could be avoided with wise use of supplementation.

The Cholesterol Connection

The human body is amazingly resourceful at bio synthesizing what it needs from what we put into our bodies. Thus when we have a deficiency of vitamin d the body will make it from cholesterol. This can cause your cholesterol levels to rise, because your body needs the extra cholesterol in order to synthesize this vitamin/hormone.

You have read in this blog that lowering cholesterol is not necessarily needed to prevent heart disease because it has been found not to be a direct causative factor. However if your cholesterol levels are elevated because of a lack of vitamin d then you need to take steps to supply your body with this nutrient by getting more sun exposure and taking supplements when you can’t get enough sun, such as in the winter.

Elevated cholesterol levels can indicate other problems in your body that you need to address. This is another reason why statin use can be problematic. It can mask the symptom (elevated cholesterol) that is being caused by another problem (like vitamin d deficiency).

Effects of Vitamin D Deficiency

  • increased risk of heart attack and stroke
  • depression
  • Parkinson’s Disease
  • increased risk of cancer
  • increased risk of infection
  • increased risk of multiple sclerosis

Some Food Sources of Vitamin D

  • Cod liver oil
  • Butter from grass fed cows
  • Beef or Calves liver
  • Egg yolks
  • Cheese
  • Water packed tuna
  • Oil packed sardines

Supplementing Vitamin D

Supplementary forms of this vitamin can be found in any health food store. My favorite is Jarrow Formulas D3. I opt for 5,000 units per day in the winter and half that dosage in the summer. It is difficult to overdose on this vitamin, as long as you are not using a synthetic version of it.

The ideal situation is that you get your levels tested by a doctor and do follow ups until the levels are where they are supposed to be. This is a fat soluble vitamin and so should be taken with a meal that contains healthy fats.

Vitamin k2 should be taken with vitamin d as those two nutrients work togegher to ewnsure that your body handles calcium properly. One of the top experts on vitamin K2 Dr. Rheaume Bleue suggests a ratio of 100-200 micrograms of K2 for every 1,000 IUs of vitamin d.   Again I would go with Jarrow Formulas MK-7, combined with their D3 product.

Sun Expose is Healthy

It’s been said before, but bears repeating…sun exposure is HEALTHY! Human beings evolved on the surface of the Earth. We NEED sun exposure in order for out bodies to function properly. Don’t avoid getting sunlight, because if you do, you are undermining your health in a critical way.

sunshine vitamin

sunshine helps your body synthesize vitamin D

Use common sense of course. Don’t overdo it, as too much of anything can be a problem, but remember that getting out in the sun and fresh air has benefits that go far beyond making you feel good and improving your mood.

How Much Sun Exposure?

This depends on how dark your skin is. Light skinned people should avoid prolonged exposure such as beyond 10-15 minutes in the sun. Darker skinned people of course can tolerate longer exposure, but you should be conservative with your time in the sun and gradually build a tolerance to sun exposure over time as you get more tanned.

Wearing a wide brim hat, proper sunglasses, and long sleeve clothing can help protect you as well. Remember also that you can get burned even on a hazy day because enough of the suns rays still get through and you may not be aware of how long you have been exposed.

Remember also that sunblock will prevent your body from making the vitamin d it needs from sun exposure, so If you are using sun screens on your skin you are defeating the purpose of getting sunlight.

artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

fasting blood sugar testThe fasting blood sugar test will actually tell you more about your risk of heart disease than your cholesterol profile. Are you surprised?

Don’t be! While this is not a “cholesterol test,” it IS an important marker for heart disease risk!

Sugar is intimately involved with inflammation, and as we know, it is inflammation that is the real culprit in heart disease, cholesterol is just along for the ride!

According to Dr. Mark Houston associate professor of medicine at Vanderbilt University, for every additional point above 75 on your fasting blood sugar reading, your risk of heart disease goes up!

This is due to the fact that high blood sugar levels in your blood are an independent risk factor for cardiovascular disease.

The impact of elevated blood glucose levels

Sugar is a killer, a serial killer, where your health is concerned. Medical science is just now starting to figure out how damaging sugar can be in your system when the levels are high.

There are a number of reasons for this:

  • High blood sugar causes increased insulin (which is a pro-inflammatory hormone)
  • Elevated sugar levels make your blood more acidic and it tends to clot more readily
  • Sugar causes stiffening of arteries and blood vessels
  • Sugar decreases the oxygen carrying capacity of your blood
  • Nitric oxide is vital for heart health and high sugar levels lower it
  • High sugar levels also cause glycation which is a hardening of tissues in your heart and arteries

For all the reasons above, it’s important to know what your blood sugar levels are, so that if they are high, you can make the necessary changes that will bring the level down and reduce your risk of heart attacks, strokes, and high blood pressure.

How is the test performed?

A fasting blood sugar test, which is also called a fasting plasma glucose, or FPG test, measures your blood glucose level after you have fasted for at least 8 hours.

It’s a very accurate test, and does not vary by age or how physically active you are. It tends to be a physician favorite because it’s easy to do, cheap, and you get the results relatively fast.

The test is done first thing in the morning (so you can get the results by the afternoon), after at least an 8 hour period with no food, and nothing to drink but water.

A nurse or physician assistant will draw your blood and send the sample to the lab. When the results come back your doctor will discuss with you what the results mean, in terms of your risk for both heart disease and diabetes.

Levels for these tests are expressed in “millgrams per deciliter” (a deciliter is one 10th of a liter). Thus a reading of 100mg/dl is read as 100 milligrams per deciliter.

The threshold for normal fasting sugar levels should be below 100mg/dl, but some experts, most notably Dr. Mark Houston, feel the safe level is 70 -75 mg/dl!

What do the scores mean?

Doctors use what are called “reference ranges” to determine exactly what these tests indicate. All of this is of course relative to the results taken of sample populations to determine what is statistically healthy and what is not.

There are cut off points beyond which a clinical diagnosis is made, and these would appear to be splitting hairs so to speak, but of course the line must be drawn somewhere.  Whatever the result, you will have a much better idea of where you stand, and what you have to do to protect your health in the long term.

If your blood sugar measures between 100 mg/dl to 125 mg/dl, the doctor will probably order a follow-up test to eliminate error. This test result indicates “pre-diabetes” and your doctor may want to discuss steps you can take to bring your sugar levels down and prevent diabetes.

If you score 126mg/dl or above, the doctor will want to test you again to eliminate the chance of some anomaly that might have caused an inaccurate reading. If a follow-up test scores the same result, this will confirm that you are diabetic!

Of course it may seem silly to say that if your result on this test is 125mg/dl you don’t have diabetes and at 126 mg/dl you ARE diabetic, but they had to make a cut off point somewhere.

What is important is that if you are in the range 100-125 you need to make changes to your nutrition and exercise habits to get your blood sugar down to healthy levels.

Insulin is a factor too!

When your blood sugar levels spike, your body produces insulin to lower the sugar level. So if your fasting blood sugar test indicates higher than normal blood sugar levels, you can be sure your insulin levels are high as well.

Insulin is a very pro-inflammatory hormone that causes a lot of problems in your body when it is chronically elevated. This is another reason why you would want to get your sugar levels down to what is considered healthy.

Insulin causes inflammation and damage to the endothelial lining of your arteries, which is how the process of atherosclerosis begins. Thus your sugar levels have a direct bearing on the development of heart disease.

Connection with heart disease

If your blood glucose levels are chronically elevated, a process called glycation comes into play, which causes tissues like the heart and blood vessels to lose elasticity and become stiff.

This stiffening process, along with the damage from inflammation, makes you susceptible to heart attacks, high blood pressure and strokes.

To make it really simple and clear, elevated blood sugar=heart disease! This connection is far more important than cholesterol which does not directly cause heart disease. High blood glucose levels are also a factor in many other chronic diseases as well.

The fasting blood sugar test, by measuring how high your blood sugar is on average gives you a clear indication that your risk for heart disease is elevated, which in turn gives you a chance to lower your risk and avoid heart disease, by bringing your blood sugar levels down.

soy lecithing granules

Lecithin as a food to lower cholesterol is another natural strategy to improve your lipid (fat) profile without the use of toxic drugs, such as statins.

Lecithin is a compound found in soybeans, eggs,  sunflower, and other sources, which has the ability to help lower cholesterol levels.

Remember that when we talk about lowering cholesterol, we are really referring to optimizing your cholesterol levels. Cholesterol is often elevated by other things going on in the body. Things like insulin resistance, vitamin-d deficiency, and stress can all raise cholesterol levels.

When levels are high often this indicates that there are problems with the body that can be serious if they are not taken care of. High cholesterol levels are like the “canary in the coal mine” so to speak. If they are elevated we need to make sure we know why, and correct it.

Lecithin (also called phosphatidylcholine) is a “phospholipid compound” that supplies the b-vitamin choline, which is vital to the health of your brain and nervous system. This natural compound (lecithin) can help promote healthy cholesterol levels, but there are some things you need to know before you add it to your diet!

As a food to lower cholesterol, soy lecithin (from soybeans) may not be the best way to go, as soy contains phyto-estrogens and can cause a number of problems especially for men.  Sunflower lecithin on the other hand does not pose those problems and so would be a much better way to go, if you are using it to improve your cholesterol profile.

The following foods are sources of lecithin:

  • Animal sources:  eggs, meat, dairy
  • Vegan sources:   nuts, seeds, soy, sunflower

Eggs contain the highest amounts for any animal based food, and if you are a vegetarian, you would likely have to supplement with lecithin granules, preferably made from sunflower plants, instead of soybeans.

These lecithin granules have a pleasant nutty flavor and can be added to either liquid or solid food depending on your taste and preferences. They are one of the few things that are good for you that actually taste good!

This food does act as an emulsifier (mixes water and oil) and can be used in blending protein drinks or vegetable smoothies such as you might make in the Nutribullet! Dr. Peter D’Adamo has a recipe for something he calls the “Membrane Fluidizer Cocktail,” or “Membrosia Cocktail.”

The recipe goes something like this:

Use guava, grapefruit, or watermelon juice as a base
add 1/2 to 1 tablespoon of high-quality flaxseed oil
plus 1 tablespoon of good-quality lecithin granules
shake well until the consistency is uniform
and..enjoy!

Buying and storing lecithin

Make sure that the lecithin granules that you buy in the store are kept under refrigeration, because they oxidize (turn rancid) very easily when they are exposed to light or heat. Always check the expiration dates and pick the freshest bottle. When you get home store your lecithin in the refrigerator at all times!

Lecithin to lower cholesterol……does it work?

I have been unable to find any evidence that lecithin acts as an emulsifier and “flushes” the cholesterol out of your arteries as some people claim. It just doesn’t appear to work in this way. However choline is necessary for optimal health and promoting healthy cholesterol levels.

As a food to lower cholesterol, lecithin provides your body with a good source of choline and for this reason it likely has a positive effect on cholesterol levels. The benefits of lecithin from food sources and supplementation is really enhancing the function of your brain and nervous system.

Since the nervous system is involved in regulating cholesterol metabolism, any thing you do to make it function better will result in an improvement in your cholesterol profile.

Supplementary lecithin comes in either granules or gel caps, which are rather large and may be hard to swallow. When I use lecithin I prefer the granules, and I try to use sunflower lecithin rather than soy lecithin for the reasons I mentioned above.

Do not put lecithin into anything hot, as heat degrades lecithin (it’s poly unsaturated). Follow the dosage recommendations on the label. Since lecithin is a concentrated source of choline, you don’t need a lot.

Remember that lecithin, as a food to lower cholesterol does work but not for the reasons you have likely been told. It provides choline to your body which is essential to the health of your nervous system and thus your body’s ability to maintain healthy cholesterol levels.

medical references:

J Nutr. 1990 Jul;120(7):659-67.
Evidence that polyunsaturated lecithin induces a reduction in plasma cholesterol
level and favorable changes in lipoprotein composition in hypercholesterolemic
rats.
Jimenez MA1, Scarino ML, Vignolini F, Mengheri E.

J Am Diet Assoc. 2003 May;103(5):577-81.
Fat-free foods supplemented with soy stanol-lecithin powder reduce cholesterol
absorption and LDL cholesterol.
Spilburg CA1, Goldberg AC, McGill JB, Stenson WF, Racette SB, Bateman J,
McPherson TB, Ostlund RE Jr.

Atherosclerosis. 1998 Sep;140(1):147-53.
Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in
hypercholesterolemic monkeys and hamsters: beyond linoleate.
Wilson TA1, Meservey CM, Nicolosi RJ.

pantothenic acid capsulesPantothenic acid benefits are not well known to most people but they have important effects on your cardiovascular health. D-calcium pantothenate is helpful in raising HDL cholesterol level, which helps lower your risk of heart disease.

Since the cutting edge in modern medicine involves the use of targeted nutritional supplements to fight disease rather than defaulting to drugs as a first resort, we need to become familiar with some key nutrients and learn how they can help protect against heart disease!

What is pantothenic acid?

D-calcium pantothenate or pantothenic acid is a water soluble b-vitamin (vitamin-b5). It is a very important nutrient and is a precursor to coenzyme A. Coenzyme A is utilized in the metabolism of carbohydrates, and the synthesis of fatty acids, and steroid hormones.

Deficiency of this vitamin in human beings is rare and usually only occurs in bad cases of malnutrition. Symptoms of deficiency include numbness and tingling in the hands and feet, fatigue, headaches, and insomnia.

Pantothenic acid benefits

There are a number of well documented health benefits associated with d-calcium pantothenate such as:

  • Raises HDL cholesterol level
  • Improves skin tone
  • Accelerates healing
  • Protects against lipid peroxidation
  • Increases energy levels
  • Accelerates post surgery healing
  • Helps healing after burn injuries
  • Enhances epithelial function

The most important of the pantothenic acid benefits is it’s ability to raise HDL levels. This is what most directly affects your risk of heart disease. Pantethine is the active form of vitamin B5. Clinical research studies show that pantethine can reduce triglycerides and cholesterol levels and increase HDL levels at the same time.

Food sources of d-calcium pantothenate

Pantothenic acid can be found in common foods and also taken in supplement form. You can get it in the following foods:

  • Meats
  • Whole grains
  • Egg yolks
  • Vegetables like broccoli and avocado
  • Rice
  • Cold water fish

Pantothenic acid benefits can also come from supplements of d-calcium panothenate taken in dosages of 50-100 mg per day. There is no known toxicity threshold for this nutrient and dosages of several grams per day have been reported as having beneficial effects with no signs of toxicity.

Since few doctors are familiar with nutritional supplements and how they should be used, your doctor will probably not be receptive to the idea or know just how these nutrients should be incorporated into your diet.

You should seek the advice of a doctor who practices complementary and integrative medicine, as the best person to advise you in this area. These doctors combine traditional treatments with nutrition and holistic therapies, to get the best results of both approaches.

The best approach is to calibrate the dosage with how you feel and what your objectives are. Raising HDL cholesterol is the most notable of d-calcium pantothenate effects, and you should adjust your dosage to optimize your HDL levels. You may want to have your HDL cholesterol checked to provide a baseline to compare against. This way you will know if it is working.

Pantothenic acid benefits are that this powerful nutrient can help optimize your cholesterol profile and significantly lower your risk of heart disease. It is non toxic and vital to energy production. When you add this vitamin to your nutritional regimen you will significantly improve the quality of your life.

cholesterol reducing drugsCholesterol reducing drugs are huge sellers for the drug industry, but are they safe? Cholesterol reducing drugs or cholesterol meds as they are referred to artificially lower cholesterol.

High cholesterol medication may not effectively prevent heart disease, and each new cholesterol drug seems to have it’s share of dangerous side effects.

Mainstream medicine’s reliance on medication for bringing down high cholesterol levels may very well be unfounded. Funding for research studies into the effectiveness of these drugs is often conducted by the very companies that stand to profit if the drug is approved. This is a huge conflict of interest, and it may even mean that the claims made for the effectiveness of cholesterol lowering medication are exaggerated or false.

The most popular class of cholesterol reducing drugs are called statins. They are taken by more than 25 million people around the world to lower cholesterol. In fact, the statin drug called Lipitor is the most widely prescribed drug in the world!

Some of the brand names of these statins are:

  • Lipitor
  • Pravachol
  • Vytorin
  • Zocor
  • Crestor

These drugs and many other cholesterol meds work by inhibiting an enzyme called HMG-CoA reductase, that is responsible for the production of cholesterol your liver. These drugs actually replace the HMG-CoA in your liver, which triggers the production of what are called LDL receptors, which attach to the cholesterol molecules and transport them to the liver where they are deactivated.

The problem with using these drugs to lower your cholesterol levels is twofold:

  • They are toxic and damage your liver
  • Your body actually needs cholesterol for many important biochemical reactions

Thus lowering your cholesterol by interfering with the production of this vital substance in your body is a dangerous practice that an increasing number of doctors feel is not worth the risk of side effects that these Cholesterol reducing drugs cause.

Statins contained in medicine to lower cholesterol, deplete a substance in your body called coenzyme q-10 which is used in many vital chemical processes in the body. One drug company was even working on a synthetic form of coenzyme q-10 that would be part of their cholesterol medicine, in order to prevent deficiencies of q-10 from causing side effects in the people taking their statin drugs.

However this product containing supplementary coenzyme q-10 never made it to commercial production. So when people take statins, they become deficient in this critical nutrient, and are not even aware they are at risk for some serious problems such as cancer, cardio myopathy, and Alzheimer’s disease, to name a few.

It goes without saying that anyone taking medicine to lower cholesterol should be taking supplementary coenzyme q-10 to protect themselves from deficiency cause by statin drugs.

Some health experts feel that the increases in cases of cancer, Alzheimer’s disease, rhabdomylosis (a medical condition that causes muscle breakdown), are due to the widespread use of cholesterol reducing drugs containing statins. Some doctors continue to aggressively promote and prescribe these drugs to their patients.

However other physicians, alarmed at the side effects of statins they are seeing, believe that the risks of these drugs are so great that their use in supposedly preventing heart disease is not justified.

Some of the warning signs of serious side effects are:

  • Persistent muscle pain
  • Numbness in fingers and toes
  • Loss of memory
  • Headache
  • Weakness or lack of energy
  • Rashes
  • Dark colored urine

These are just some of the signs that you are experiencing potentially serious side effects from a new cholesterol drug you are taking. These symptoms should be reported to your doctor right away. If the doctor you are seeing does not take them seriously or seem concerned, you should change doctors.

Cholesterol reducing drugs can have deadly side effects. It is best to pursue ways to lower cholesterol without dangerous drugs. Seek out a doctor that is knowledgeable about nutrition and natural ways to lower cholesterol. It just may save your life!

Raise good cholesterol with Coenzyme Q10, and lower inflammatory LDL particles at the same time.  Sure sounds like a win-win situation for heart health, and recent research strongly supports this important role for Co Q10!

coenzyme q10 moleculeLets take a look at this new nutritional weapon against heart disease, and the other health benefits of Coenzyme Q10.

What’s Coenzyme Q10?

Coenzyme Q10 or CoQ10 as it is also referred to, was discovered by Professor Fredrick L. Crane and his research team at the University of Wisconsin–Madison Enzyme Institute in 1957.

The reduced form of CoQ10 was called ubiquinone and was identified as a powerful antioxidant and free radical scavenger, and as we will see…it also has the ability to raise good cholesterol and lower inflammatory LDL.

This fat soluble antioxidant is found in the membrane structure of the mitochondria and is a key player in the electron transport chain which functions as an energy creating mechanism in your cells. The end product of these reactions is the creation of ATP, the primary source of energy for your body.

Because of it’s vital role in cellular energy production CoQ10 is found in highest amounts in the organs and tissue that have the highest energy demands.  Your body can synthesize CoQ10 but you also need to acquire it from your diet and possibly from supplementation as well.

How Do You Get Coenzyme Q10?

You can get CoQ10 in tablet form or as a soft-gel. The softgel form is superior because it’s easier for your body to absorb. The usual dose when used to benefit the heart is from 50 to 150 milligrams. The most effective form is the “reduced” form which is called “ubiquinol.”

Food sources of CoQ10 tend to be from animal sources, such as organ meats like liver, heart, as well as muscle. Again this is because those types of organs and tissues have a high demand for energy, and CoQ10 is a vital component of energy production in both animals and humans.

Here are the top foods sources:

  • Pork heart
  • Pork liver
  • Beef heart
  • Beef liver
  • Chicken liver
  • Chicken heart
  • Sardine
  • Mackerel

If you are a vegan there ARE  vegetable sources of Coenzyme Q10, the best are whole grains, peanuts, wheat germ, broccoli, and spinach. Keep in mind though that these sources are a lot lower in CoQ10 than animal proteins, so if you are trying to make up for a deficiency in Coenzyme Q10 you may need to use a supplement like ubiquinol if you are eating a vegan diet.

Health Benefits of Coenzyme Q10

There are many health benefits of Coenzyme Q10 from protecting yourself from heart disease, to blood sugar control and better energy.  Here is a short list of medical conditions where Coenzyme Q10 can be beneficial:

  • Malignant Melanoma
  • Diabetes
  • Endothelial Dysfunction
  • Heart Disease
  • Alzheimer’s Disease
  • Senile Dementia
  • Hypertension (high blood pressure)

CoQ10 is both an antioxidant and a bio-energetic nutrient, which means it both protects cells against oxidative stress (which robs the cells of energy) and also has a vital role in making the ATP molecule that supplies energy that cells need to maintain and repair themselves.

Coenzyme Q10 and Cholesterol

CoQ10 has beneficial effects on cholesterol profiles because of it’s role as a powerful antioxidant and free radical scavenger.  It’s been established that heart disease results from inflammation and free radical damage to the heart and the arteries through which blood flows.

By fighting oxidative stress and the free radicals it produces, CoQ10 can help prevent the damage to the endothelium and the process of atherosclerosis that causes coronary artery disease. The effect of CoQ10 on cholesterol is that it will raise good cholesterol (HDL) and lower LDL.

Even though we have learned recently that cholesterol does not CAUSE heart disease, it is a FACTOR in atherosclerosis that damages arteries. Coenzyme Q10 has been shown to alter the ratio of HDL to LDL that helps protect against coronary artery disease.

Cardiologists like Dr. Stephen Sinatra have been using Coenzyme Q10 to treat heart disease for many years, and now his colleagues are beginning to embrace this nutrient and add it to their treatment protocols, because of it’s ability to raise good cholesterol and lower inflammatory LDL particles.

Coenzyme Q10 and Statins

Statins, the drugs most often given to people to lower cholesterol have some very serious side effects. Some prominent cardiologists have come out against widespread statin use because the benefits of these drugs are far outweighed by the dangers to health that these drugs pose.

Statins deplete Coenzyme Q10, leaving the body vulnerable to a number of damaging processes that are rooted in oxidative stress and free radical damage. It is for this reason that a number of cardiologists recommend that in cases where statins are used the patient MUST be given Coenzyme Q10 in supplement form to protect against this statin caused deficiency.

The Case for Co Q10

Cardiologists are starting to use it, and in fact it has been used for many years in Japan to treat heart disease. Incidentally the Japanese are the longest lived population in the world, so it seems they know a thing or two about the health benefits of Coenzyme Q10.

The ability to raise good cholesterol with Coenzyme Q10 is the real value of this nutrient in helping to treat and prevent heart disease. Given the fact that heart disease is the number one killer of Americans, Coenzyme Q10 may prove to be one of the most effective strategies to keep your cardiovascular system healthy and extend your life.

The PLAC test is a cutting edge medical screening test that identifies arterial The PLAC Testplaque that is in danger of rupturing. This test, used in conjunction with other cholesterol screening tests can pinpoint your risk of a sudden heart attack with a much greater degree of certainty.

The test actually measures levels of an enzyme in your blood known as lipoprotein phospholipase A2. This enzyme is responsible for a process that can cause damage to your endothelial layer and set the stage for atherosclerotic plaques which can rupture and trigger a heart attack.

When your levels of Lp-PLA2 are elevated, it indicates that you have plaque that can rupture and create a blood clot that results in a heart attack or stroke.

The most current information we have tells us that using cholesterol levels to determine your risk of heart attack is not very accurate. However medical science has identified a process where LDLs (low density lipoproteins) and Lp-PLA2 particles undergo oxidation by free radicals.

These oxidized particles then attack the blood vessel wall causing damage and making the plaque deposits hard and brittle. This oxidized brittle plaque can then break off and cause life threatening problems such as a heart attack or stroke.

Lp-PLA2 is actually created in atherosclerotic plaques and thus can serve as a marker for inflammation in the artery wall. People who have heart disease show high levels of this marker (Lp-PLA2) which not only indicates they have plaque buildup, but also that the plaque is oxidized and can cause severe cardiovascular events.

Autopsies on patients who died suddenly of heart attacks showed ruptured plaques and high levels of Lp-PLA2 in their arteries.

This has also been see in patients who undergo surgery for carotid artery atherosclerosis. They show the same high levels of Lp-PLA2 that indicates a danger of rupturing plaque.

Those people who showed atherosclerosis of the carotid artery but did not show symptoms had much lower levels of Lp_PLA2. It’s clear from this evidence that this is a very significant and useful marker for predicting sudden cardiovascular events.

Studies done at the May Clinic also found that Lp-PLA2 was a specific indicator of dangerous plaques even in the absence of other risk factors. This indicates that it is inflammation and not merely cholesterol levels that create the risk of sudden heart attacks and stokes, so it is inflammation that we should address in our efforts to prevent heart disease.

Advantages of the PLAC test:

  • The test more accurately predicts the risk of sudden heart attack or stroke than other lipid screening tests.
  • The test directly measure lipoprotein phospholipase levels, a very accurate inflammation marker.
  • The PLAC test is the only medical screening approved by the FDA that indicates both heart attack and stroke risk in patients.
  • The test is relatively inexpensive and convenient.
  • The test can also be used to monitor a patients response to treatment and lifestyle changes.
  • The test is covered by Medicare and private insurance companies.
  • The test does not have to be taken in a fasting state.
  • The test can be used in patients that are currently using Pravachol, Benadryl, and Tylenol

Who should get the PLAC test and when?

Experts recommend a formula for determining who should get the test based on other risk factors and their estimate risk of sudden heart attack within a ten year period. This makes no sense to me at all. We have a test that can specifically identify people who are a high risk for a heart attack or stroke, before this actually happens and give them a chance to lower their risk.

I believe the PLAC test should be used as a standard cardiovascular screen test, because it targets the process that is actually dangerous, rather than cholesterol levels which don’t really give an accurate measure of your risk. Once the test has been done, all that’s left is to determine how to go about lowering the risk, by reducing the inflammation in your arteries.

As to who should have it done, it makes sense to me that anyone approaching middle age would be a candidate for it. Autopsies of US soldiers killed during the Korean War showed atherosclerotic plaques in the arteries of young men in their 20’s. Based on this it seems reasonable that the test could even be done on people in their early 20’s as a way of identifying people who may be at risk and giving them plenty of time to make the lifestyle changes needed to protect themselves.

People with metabolic syndrome which consists of the following:

  • obesity
  • abnormal blood lipid profile
  • elevated blood sugar
  • high blood pressure

are prime candidates for the PLAC test, as it is known that metabolic syndrome involves inflammation and thus raises the risk of heart disease.

The test can be done at followup intervals to verify the success of lifestyle changes and other interventions in terms of lowering the patient’s risk. While I claim no medical expertise, common sense suggests that this test be done early and the person then adapt their lifestyle, nutritional and exercise habits to mitigate this risk. That approach makes the most sense.

How to interpret the test results:

Even though the Lp-PLA2 test is much different than cholesterol screening tests, the levels are somewhat similar:

The 3 risk levels are:

Low:   under 200 ng/mL

Borderline:  200 to 235 ng/mL

High:  over 235 ng/mL.

Lp-PLA2 levels over 200 to 220 ng/mL indicate a very high risk of endothelial damage which in turn presents a very high risk of atherosclerosis.

Medical Interventions:

The PLAC test can be used to identify the magnitude of risk and also to determine how well the treatments used to combat it are working. This is why followup tests are important.

Statin drugs are said to provide a 20-30% reduction in Lp-PLA2 levels. The risk to benefit ration of statins is something you will have to discuss with your doctor.

Niacin used in combination with statins is reported to provide an additional 5 to 20% further reduction of the Lp-PLA2 enzyme.

Angiotensin-converting enzyme (ACE) inhibitors are also reported to lower Lp-PLA2 levels, and medical scientists have speculated that the effectiveness of all cardiovascular drugs may actually depend on their ability to successfully lower Lp-PLA2 levels

Niacin and omega 3 fatty acids (fish oil) also show an ability to reduce levels of Lp-PLA2.

Tumeric spice (also called circumin) has been found to reduce a form of phospholipase in animals, and thus may be of value to humans in reducing Lp-PLA2 levels, but the study results are not in on this yet. My guess is however that turmeric is most probably of value in human as well.

Conclusion:

Since heart disease is the nation’s number one killer, preventing it is vitally important to a long and health life. Medical screening tests such as blood pressure and cholesterol are not enough to accurately predict who is a risk for a heart attack or stroke.

The PLAC test is relatively inexpensive, non invasive, and very accurate in predicting who is at high risk for a sudden cardiac event like a heart attack or stroke. It really represents a cutting edge approach to identifying people at high risk and helping them make the changes that can save their lives.

Cholesterol too low, how can this be a problem? We have all heard about the supposed relationship of heart disease to cholesterol levels, so we assume that lower is better. NOT SO!

cholesterol too lowEverything in your body is based on maintaining a balance, and cholesterol profiles are no exception.  Low cholesterol levels can be just as unhealthy as levels that are too high.

The belief that simply lowering cholesterol will protect you from heart attacks has been encouraged by the pharmaceutical industry and those medical professionals that serve it.  While cholesterol is a factor, there are other things involved such as inflammation, that make a big difference.

The risks of various serious medical conditions rise for those individuals having a total cholesterol level of under 160 mg/dl (milligrams per deciliter).  That said, some experts recommend that the ideal is somewhere between 180mg/dl and 200mg/dl for total cholesterol, (but even this is subject to controversy)

What causes low cholesterol?

Cholesterol that’s too low can be caused by:

  • Use of statin drugs
  • Malnutrition
  • Malabsorption – inadequate absorption of nutrients from the intestines
  • Hyperthyroidism
  • Liver dysfunction
  • Manganese deficiency
  • Celiac disease
  • Leukemia and other blood diseases

Please note:  Excessively low cholesterol levels need to be evaluated by a trained medical professional to determine the cause and the proper treatment. It is important not only to know what causes low cholesterol, but also having a proper treatment strategy in place to make sure you address it.

When you optimize cholesterol naturally, this is not a problem, because you are not trying to curtail your own body’s production of cholesterol, but rather preventing re-absorption through the large intestine.

You will NOT bring your cholesterol too low with this approach.

Effects of low cholesterol

Hypocholesterolemia – cholesterol too low, has been associated with a number of serious medical disorders such as:

  • Reduced production of your body’s steroid hormones
  • Increased risk of cancer
  • Increased risk of heart disease
  • Increased risk of strokes
  • Increased risk of depression/bipolar disorder
  • Increase risk of Alzheimer’s disease
  • Loss of sex drive
  • Possible loss of memory
  • Increased risk of suicide
  • Increased risk of schizophrenia

Effects of low cholesterol are very serious, and you need to focus not on simply lowering cholesterol, but achieving a healthy level based on your individual biochemistry.  With cholesterol too low, many vital chemical processes can’t be completed properly.

Cholesterol too low? – So what is the right approach?

The correct approach is not to simply focus on lowering cholesterol, just as weight loss should not simply be about losing weight.  Rather than making your cholesterol too low, this process will allow you to achieve the right balance.

That process includes:

  • Proper eating
  • Proper exercise
  • Nutritional supplementation
  • Stress reduction

Proper eating should include foods that are low in cholesterol but also nutrient dense, and which contain plenty of fiber. This is because fiber can absorb excess cholesterol as it passes through the large intestine and is then excreted out of the body in the stool.  The recommended fiber consumption is about 25 grams per day for women and 38 grams per day for men.

Proper exercise is short and intense, like interval training, but ultimately should be moderated by the age and physical condition of the person doing it. Be cautious and seek professional guidance in setting up an exercise program if you are an older person, or if you have a serious medical condition.

Nutritional supplementation should include full spectrum vitamin and mineral formula. A high quality fish oil is also a key supplement that will lower your risk of heart disease and every other medical condition you can think of. Sufficient levels of omega 3 fatty acids are essential to good health, and fish oil supplies these.

Stress reduction uses various techniques to lower stress and promote relaxation and tranquility. Among these, grounding is one of the most effective. Other strategies like meditation, the speed trace, and various other relaxation techniques can be very effective.

Having your cholesterol too low is a risk factor for chronic disease. A balanced approach, rather than just low cholesterol levels is the answer. Doing the things mentioned above should allow you to naturally achieve the right balance.