pantethine-capsulesGood cholesterol levels can be achieved easily and naturally using pantethine, which is what I call a heart healthy nutritional supplement.

It is a derivative of vitamin b5 and it’s made up of two molecules of pantothenic acid linked together by what’s called a cysteamine bridge.

It is an intermediate step in the synthesis of  Coenzyme A, which in turn is involved in various enzymatic reactions including the production and oxidation of fatty acids.

pantethine molecule

Pantethine is what’s called the “active” (more biologically available) form of the vitamin b5, but unlike the more well known form calcium pantothenate, it is less stable and will degrade if not refrigerated.

The theory is that since it’s closer biochemically to coenzyme A, it is more beneficial than pantothenic acid. It’s involved in the activation of coenzyme A and helps transport fatty acids across the cell membrane into the mitochondria to be used to make ATP, (a key component in health).

However as you will see it’s benefits go far beyond improving your cholesterol hdl ratio!

How does it work and what does it do?

Biochemistry details aside, the bottom line for the average person is “what does it do?” Dr. Stephen Sinatra has stated that in every type of heart disease, what we find is an energy starved heart! The role of pantethine in cellular energy production is a big part of it’s beneficial effect on heart health.

The heart is a very energy intense organ, and the ability for the cells of the heart to produce  energy in the form of ATP affects every aspect of your heart function, from contraction to the electrical signaling that keeps your heart beating strongly and evenly.

Pantethine is right in the middle of all of this because it is a key player in the production of ATP in the mitochondria of your cells. In plain English, it boosts energy not only to your heart, but all the organs and systems of your body!

It  has been shown (in animal experiments) to lower LDL cholesterol and raise hdl cholesterol, improving the cholesterol hdl ratio, as well as decreasing triglycerides. The ability of pantethine to promote good cholesterol levels is highly beneficial to heart health.

In addition is increases levels of apolipoprotein A1, which is the component of HDL responsible for transporting cholesterol away from the arteries and back to the liver. Pantethine also functions as an anti stress nutrient, due to the fact that it supports the health of your adrenal glands and protects the health of your hormonal system particularly when you are under stress.

Pantethione also protects your brain in several ways. It promotes the synthesis of Coenzyme A (CoA) which in turn is used in the production of the neurotransmitter acetylcholine, which is critical for healthy brain function, and a lack of this neurotransmitter can lead to Alzheimer’s Disease.

It’s positive effect on the synthesis of CoA improves the efficiency of your heart and in turn improves blood flow to the brain. Pantethine has also been shown to be beneficial for the immune system, detoxification, arthritis, and wound healing. It is used also to treat acne, and also for gout and CFS (chronic fatigue syndrome).

So the evidence is that pantethine…

  • Improves hdl cholesterol levels
  • Improves ldl cholesterol level
  • Protects the brain by boosting acetylcholine
  • Improves heart function and blood flow
  • Can be used to treat acne
  • Is helpful in Chronic Fatigue Syndrome
  • Improves detoxification
  • Strengthens the immune system
  • Combats arthritis
  • Can be used to treat gout

How is it taken (form and dosage)

Pantethine as a nutritional supplement is taken orally in capsule form. Clinical research protocols have used as little as 300mg per day with statistically significant result. Levels of 600mg to 900mg have been used in research and yielded very significant reductions in LDL levels for subjects with elevated cholesterol levels. In general though there is little information to use as a guide for precise dosage levels.

Remember that where dosages are concerned, more is not necessarily better. The best course of action would be to use this supplement under the guidance of a complementary physician who can do follow up blood work and determine the correct dosage based on that.

This supplement should work at a relatively low dose, even as low as 5mg to 50mg per day. Start with the lowest dosage and work upwards until you find what works for you.

There are home cholesterol tests that you could use to establish a baseline reference and follow up test would tell you if the pantethine was having an effect. You would have to be careful to account for all the variables in your diet and activity level, and even at that it would not be a “scientifically accurate” result, but enough for you to determine whether pantethine was actually promoting good cholesterol levels.

Side effects

Large amounts of this supplement could potentially block absorption of other b vitamins. It could also cause fatigue, numbness in your hands and feet, or headaches. It’s effect on peristalsis could cause more frequent bowel movements or diarrhea.

The toxicity of this supplement is extremely low, and it has been termed “well tolerated” which is medical jargon for having few side effects. It is not likely that toxicity would be a problem at the dosages that would have benefit.

Brands to look for

Brands I like are:  Jarrow Formulas, Life Extension, and Pure Encapsulations. You really can’t go wrong with these companies when it comes to the quality of the supplements they sell. To be sure there are other good brands, but these are the ones I know of to be top notch.

To Sum Up

This is a supplement that can be helpful in many conditions due to it’s vital role in cellular energy production. Think of it less as something “medicinal” and more as a substance your body needs to create energy that powers all of your biochemical reactions.

Pantethine can be a powerful addition to your nutritional arsenal when it comes to promoting good cholesterol levels, combating heart disease and protecting your brain function. This article should be a starting point for your investigation and use of this fascinating supplement!

Citrus BergamotCitrus Bergamot is the latest natural supplement for lowering cholesterol levels and can also lower blood sugar as well. This new food supplement has taken the medical world by storm, even being used in place of statin drugs in some cases.

Truth be known, it’s an interesting compound but has many varied effects. It’s ability to block the synthesis of cholesterol means that it could cause problems in some people who’s cholesterol levels are too low to start with.

It is beneficial in other ways though, so it’s definitely something you need to discuss with an integrative cardiologist, if you are attempting to use it as a means of lowering cholesterol levels.

What is Citrus Bergamot?

Citrus Bergamot is a small sized tree that will blossom during winter. In terms of bitterness, it is less bitter than lemon but more than grapefruit. It is used as an ingredient in Earl Grey Tea. The juice of this plant is not consumed, but is used as a treatment for malaria, and the oil is used for aromatherapy.

A fragrant orange sized yellow green citrus fruit that is grown commercially in the Calabria region of Southern Italy. It is grown also in the southern part of France, as well as the south of Turkey.

The essential oil of Bergamot is a dark greenish-brown in color and is extracted in Cote d’Ivorie. It is grown in Antalya Turkey for use in marmalade.

Unlike other citrus fruits, Bergamot has very large amounts of polyphenols. Two of those compounds Melitidin, and Brutieridin, block the synthesis of cholesterol in the liver in much the same way statin drugs do.

It also has a similar effect to grapefruit in that it can affect the way your body metabolizes various pharmaceutical drugs.

How does it work?

Bergemot reduces the amount of triglycerides and cholesterol you would ordinarily absorb through meals. It also reduces the biosynthesis of cholesterol in the body. It also helps glucose get into cells which is beneficial for diabetics.

It blocks the HMG CoA Reductase Enzyme, which is what statin drugs do. It contains substances called polyphenolic flavanoids that suppress cholesterol production in much the same way that statins do, but it works in a different way that does not seem to deplete coenzyme Q10.

There are three main modes of action:

  • Blocks the HMG CoA Reductase Enzyme
  • Works on insulin receptors to improve shuttling of glucose into cells
  • Blocks cholesterol absorption in the intestine similar to plant sterols

What are some of the benefits of Citrus Bergamot?

  • It promotes fat burning and improves blood sugar control. This helps combat obesity and promotes weight loss.
  • It combats arterial stiffness due to it’s effect on sugar metabolism, and the benefits of the flavinoids it contains.
  • Can reduces LDL and triglycerides and increase HDL cholesterol
  • Helps in lowering blood pressure
  • Bergamot shows anti-tumor action and may be effective in combating neuroblastoma and other metastic cancers
  • It demonstrates anti-inflammatory and antioxidant properties that improve endothelial function

How is Bergamot taken?

When used for it’s cholesterol lowering effect, it would be taken in capsule form at appropriate doses, and this is where things get tricky. The medical profession knows a lot about drugs and the dosages that should be given, but not very much about vitamins, nutraceuticals, and herbs.

Citrus Bergamot capsulesDosage recommendations for this supplement are anecdotal and not the result of carefully controlled trials and years of clinical case studies and experience. Great care should be taken with this supplement, as it does mimic the effects of statin drugs, and thus could have some of the same side effects.

Given this fact, I think it’s wise to seek the advice of a complementary physician, who has knowledge of alternative treatments.

In research conducted at the Scripps Integrated Medicine Conference in San Diego California, in January 2012, they used 1,000 milligrams per day and got an average reduction in total cholesterol levels of 29%, a 36% reduction in LDL, and increase HDL cholesterol by 40%!

Reductions in triglycerides of 30%, and blood glucose of 20% on average were also noted. From this result the researches concluded that Citrus Bergamot extract at a dosage of 1,000 milligrams per day was an effective substitute for statin drugs for lowering LDL cholesterol, and also treating metabolic syndrome.

In Summary:

Citrus Bergamot is an interesting compound with some powerful effects on cholesterol metabolism, blood sugar control, and metabolic syndrome. It has demonstrated anti-tumor effects as well. However due to it’s statin like mode of action, I would very strongly suggest that you use it ONLY under the direction of a doctor who is knowledgeable about alternative medicine.

The doctor can help you determine if it’s right for you, and if so, how to arrive at a safe and effective dosage.

Research references:

Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Fitoterapia. 2010 Sep;81(6):453-61. doi: 10.1016/j.fitote.2010.01.013. Epub 2010 Jan 20.
Neuropharmacology of the essential oil of bergamot.

Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8.
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.

Fitoterapia. 2014 Jun;95:83-92. doi: 10.1016/j.fitote.2014.02.009. Epub 2014 Mar 2.
Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models.

PLoS One. 2013 Apr 16;8(4):e61484. doi: 10.1371/journal.pone.0061484. Print 2013.
Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.

Lowering triglycerides can significantly improve heart health! Your body is an totally integrated system. Knowing the cause of high triglycerides and learning how to reduce your levels will decease your risk of heart disease.

lowering triglyceridesWhile cholesterol is most often blamed for heart disease, recent scientific evidence does not support the theory that cholesterol causes cardiovascular disease. Fully half of all heart attacks occur in patients who have what are considered normal cholesterol levels. The evidence more strongly points toward triglycerides.

Triglycerides are a major factor in heart disease. An estimate two thirds of heart disease cases are at least partly a result of abnormal triglyceride levels.

There are two types of high triglycerides:

  • Familial (genetic) – usually over 400mg/dl this is not
    thought to be a cause of heart disease
  • Insulin resistant – usually 150-400mg/dl this is dangerous,
    associated with pre-diabetes and increased risk of heart disease

What are triglycerides and why are they important?

Triglycerides are lipids that are made from fats or carbohydrates you eat and are stored in the body. The higher their levels, the greater your risk for heart disease, which is why lowering triglycerides is so critical for your cardiovascular health.

Here is why elevated triglycerides are dangerous, and why lowering triglycerides is so important.

  • They are deposited in various organs including the heart
  • They can alter gene expression and increases heart disease
  • They can cause insulin resistance leading to diabetes
  • They can accumulate on artery walls causing plaque buildup
  • They thicken blood causing strokes and other circulatory
    problems
  • They contribute to abdominal obesity

What is a normal triglyceride level?

Before you go about lowering triglycerides, you need to check your levels to get a baseline so that you can tell how effective your efforts to lower them are!

The guidelines of the American Heart Association recommend that a normal triglyceride level is under 149 mg/dl.

However the Life Extension Foundation recommends an even lower level of 80-100 mg/dl measured in a fasting state.

The “fasting state” is when you have not eaten for at least 12 hours.

Unlike cholesterol, you really don’t have to worry about triglycerides going too low, so lowering triglycerides will have positive benefits for your health.  Doing the right things will bring the levels down naturally, to what is optimal for you.

Cause of high triglycerides

Just what causes these levels to become too high?

There are several factors:

  • Eating carbohydrates that raise your blood sugar rapidly
  • Problems with carbohydrate metabolism
  • Heavy drinking
  • Insulin resistance (poor insulin sensitivity)
  • A diet that consists of over 60% carbohydrate
  • Smoking
  • Lack of exercise – low physical activity
  • Obesity
  • Metabolic Syndrome
  • Kidney disease
  • Certain prescription medications (estrogen, birth control pills, tamoxifen, steroids, beta-blockers, and diuretics)

Lowering triglycerides

Lowering triglycerides really comes down to two things, restricting sugars, and getting regular exercise. Of course there is more to it than that, but those are the two most effective things.

Most people eat too many refined carbohydrates, and that is the cause of high triglycerides.

A “low glycemic diet” high in fiber will help in lowering triglycerides. This is because fiber slows down the entry of sugars into the bloodstream. Rapid entry of sugar into the bloodstream causes insulin to rise, and this promotes inflammation which in turn causes triglyceride levels to go up!

Nutritional supplements such as circumin, and green coffee extract, can also help by lowering inflammation, and helping the body manage blood sugar levels more efficiently.

Exercise also helps in lowering triglycerides  because it increases insulin sensitivity, maintains lean muscle, and mobilizes fatty acids to be burned for energy.

Below are some short simple steps for lowering triglycerides:

  • Limit your carbohydrates to mostly fresh vegetables – go easy on fruits
  • Eat what is known as a low glycemic diet
  • Avoid over consuming grains, and eating sweets
  • Eat lean proteins
  • Use nutritional supplements as you need them
  • Get some kind of brisk exercise each day

That’s pretty much it! Lowering triglycerides willboost heart health and improve the health of your entire cardiovascular system.  It’s probably the best things you can do to put yourself on a path to better health!

Soluble fiber for cholesterol is another safe and healthy way to lower cholesterol naturally, which lowers your risk of heart disease. Using fiber to lower cholesterol is a safer alternative to toxic drugs, besides which foods high in fiber have many other health benefits.

soluble fiber for cholesterFoods high in fiber have an important function in your body, and help to lower your risk of several chronic health conditions. Such fiber rich foods should be included in your diet on a daily basis.

Soluble means that your body can break them down, as opposed to insoluble which means that they pass through your digestive system without being broken down.

What foods contain soluble fiber for cholesterol?

Here is a short list of foods high in fiber.

  •     Psyllium husks
  •     Peas, beans, lentils
  •     Oats, oat bran, wheat bran,
  •     Broccoli, carrots, squash, potatoes, Zucchini
  •     Apples, oranges, tangerines, plums, strawberries, blackberries, apricots

There are more comprehensive lists of foods high in fiber online, but the above list gives you an idea of common foods that you can include in your diet to lower cholesterol naturally.

How do foods high in fiber work?

Research studies have established a positive correlation between dietary fiber and lowered cholesterol levels. There are 3 mechanisms that possibly explain this lowering effect:

  • Preventing cholesterol to be re-absorbed from bile sales and causing more of it to be excreted by elimination (feces)
  • Lowered glycemic response and reduced stimulation of cholesterol synthesis in the liver
  • Fermentation effects of soluble fiber affect bile salts and cut down on re-absorption in a way that is not well understood by science

Excess cholesterol that is not used by the body to synthesize hormones or other important functions is combined with bile acids in your large intestine, is recycled through your liver, and ends up back in your bloodstream.

Foods high in fiber can bind with the cholesterol and help transport it out of your body when you move your bowels. This is part of the way that foods high in fiber can lower cholesterol naturally, rather than using statin drugs that have dangerous side effects.

Remember as well that these sources of fiber only work optimally when you are well hydrated. Water is essential to getting the maximum benefits from fiber on your diet, so make a point to consume plenty of clean pure water throughout the day.

Using fiber to lower cholesterol does work and has been shown to be effective in well conducted studies. The role of soluble fiber for cholesterol has been known for years, but the public has only recently been made aware of it’s benefits.

You could say that using soluble fiber for cholesterol is the most natural way to optimize your cholesterol levels and fiber has other health benefits as well as it’s effect on blood lipids. Better function of your gastrointestinal system (gut) improves health across the board, and fiber has been shown to be beneficial to improving levels of pro-biotic bacteria in the colon.

Daily Recommended Amounts

The USDA recommends 14 grams of fiber for every 1,000 calories consumed for healthy adults. This works out to about 25-30 grams of fiber per day. The average for adults in the United States is approximately 15 grams.

Increased intake of fiber to lower cholesterol has also been associated with a lower risk of cancer, stroke, Alzheimer’s disease, and diabetes, as well as heart disease. Foods high in fiber thus have many benefits beyond helping to optimize cholesterol levels.

Soluble fiber for cholesterol is one of the most important strategies for maintaining a healthy cholesterol profile. Try working these soluble fiber foods into your diet, and you will automatically lower your risk of heart disease!

Soluble fiber for cholesterol – scientific references:

Food Funct. 2010 Nov;1(2):149-55. doi: 10.1039/c0fo00080a. Epub 2010 Sep 30. Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides.
Gunness P, Gidley MJ.

Am J Clin Nutr. 1999 Jan;69(1):30-42. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Brown L, Rosner B, Willett WW, Sacks FM.

What are normal triglyceride levels and how do they relate to your cholesterol levels? What are the causes of high triglycerides, and how does lowering triglycerides help your cholesterol profile?  These are important questions, and the answers will put you on a path to better cardiovascular health.

What are triglycerides?

Most fats in your body are in the form of triglycerides. They are fat molecules that are created from the fats you eat and also from sugar you eat that is converted to fat and stored in your body. Their levels correspond directly with the risk of heart disease, and thus you can lower your risk by lowering triglycerides.

Although you can have your levels triglyceride levels tested separately, they are typically tested when you get your cholesterol levels profile checked. This is standard when having blood tests done in conjunction with say an annual physical.

What are Considered Normal Levels?

Normal levels of triglycerides are defined as:

Below 150 mg/dl, (Milligrams per Deciliter )

but some experts feel that optimal levels are closer to 50mg/dl, or below, because above 60mg/dl abnormal particles begin to appear in the blood.

This elevates heart disease risk as these particles help form the plaque that narrows arteries and causes heart attacks. Thus normal triglyceride levels are actually closer to the 60mg/dl mark.  The standard of of below 60mg/dl, will lower cholesterol naturally and drastically reduce your risk of heart disease.

Elevated Triglycerides Are Bad

These fatty molecules collect in your organs (and your arteries) and damage them. They have a negative effect on gene expression and promote heart disease. They also increase the tendency of your blood to clot, which increases your risk of strokes. This is even more of a problem in people with diabetes.

Belly fat is mostly made up of triglyceries, and fat in this area of your body is associated with sharply increased risk of heart disease.  Abdominal fat is big risk factor for heart disease, strokes, senile dementia, and other diseases that involve chronic inflammation.

They can also build up in artery walls and are involved in the development of athleroschlerosis. Thuys they are considered one of the primary causes of both elevated cholesterol levels, and the process of plaque development in your arteries.

Causes of High Triglyceries

The typical causes are:

  • Excess sugar  (in the form of starchy carbohydrates, alcohol, candy, pastries, ect.)
  • Diabetes
  • Obesity
  • Metabolic syndrome
  • Lack of exercise or physical activity

All of the above issues are related and making inprovements in one area will help with the others as well. For example, exercise will lower blood sugar which in turn will lower triglycerides. Metabolic syndrome is really a collection of symptoms related to obesity.

The remdy for these issues is a healtheir lifestyle which is outlined in the steps below.

Lowering  Triglycerides

Lowering triglycerides is just as important as optimizing cholesterol.  Several strategies are effective for reaching normal triglyceride levels, and they mirror the things you would do for optimizing cholesterol as well.

They are:

Lowering your sugar intake, including processed carbs and alcohol

  • Exercise – 3 times per week for at least 15 minutes per session
  •  Niacin (vitamin B3) at dosages of 250-500 mg with food
  • Fish oil 4000 mg/day of concentrated fish oil
  •  Eat high fiber foods such as oat bran and raw nuts

Fish oil alone can result in a reduction of triglycerides of 50%, and combined with a low sugar diet and regular exercise it is possible to reach normal triglyceride levels naturally, without using any medications.

There is also new evidence that a class of compounds called tocotrienols can help safely lower both low density lipoproteins and triglycerides. Using natural nutritional and lifestyle approaches should always be your goal, because medications carry dangerous and unwanted side effects which can cause serious health problems and even make some conditions worse!

It’s pretty safe to say that achieving normal triglyceride levels is one of THE most powerfully effective strategies for optimizing your cholesterol profile and protecting yourself from cardiovascular disease!