artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

fasting blood sugar testThe fasting blood sugar test will actually tell you more about your risk of heart disease than your cholesterol profile. Are you surprised?

Don’t be! While this is not a “cholesterol test,” it IS an important marker for heart disease risk!

Sugar is intimately involved with inflammation, and as we know, it is inflammation that is the real culprit in heart disease, cholesterol is just along for the ride!

According to Dr. Mark Houston associate professor of medicine at Vanderbilt University, for every additional point above 75 on your fasting blood sugar reading, your risk of heart disease goes up!

This is due to the fact that high blood sugar levels in your blood are an independent risk factor for cardiovascular disease.

The impact of elevated blood glucose levels

Sugar is a killer, a serial killer, where your health is concerned. Medical science is just now starting to figure out how damaging sugar can be in your system when the levels are high.

There are a number of reasons for this:

  • High blood sugar causes increased insulin (which is a pro-inflammatory hormone)
  • Elevated sugar levels make your blood more acidic and it tends to clot more readily
  • Sugar causes stiffening of arteries and blood vessels
  • Sugar decreases the oxygen carrying capacity of your blood
  • Nitric oxide is vital for heart health and high sugar levels lower it
  • High sugar levels also cause glycation which is a hardening of tissues in your heart and arteries

For all the reasons above, it’s important to know what your blood sugar levels are, so that if they are high, you can make the necessary changes that will bring the level down and reduce your risk of heart attacks, strokes, and high blood pressure.

How is the test performed?

A fasting blood sugar test, which is also called a fasting plasma glucose, or FPG test, measures your blood glucose level after you have fasted for at least 8 hours.

It’s a very accurate test, and does not vary by age or how physically active you are. It tends to be a physician favorite because it’s easy to do, cheap, and you get the results relatively fast.

The test is done first thing in the morning (so you can get the results by the afternoon), after at least an 8 hour period with no food, and nothing to drink but water.

A nurse or physician assistant will draw your blood and send the sample to the lab. When the results come back your doctor will discuss with you what the results mean, in terms of your risk for both heart disease and diabetes.

Levels for these tests are expressed in “millgrams per deciliter” (a deciliter is one 10th of a liter). Thus a reading of 100mg/dl is read as 100 milligrams per deciliter.

The threshold for normal fasting sugar levels should be below 100mg/dl, but some experts, most notably Dr. Mark Houston, feel the safe level is 70 -75 mg/dl!

What do the scores mean?

Doctors use what are called “reference ranges” to determine exactly what these tests indicate. All of this is of course relative to the results taken of sample populations to determine what is statistically healthy and what is not.

There are cut off points beyond which a clinical diagnosis is made, and these would appear to be splitting hairs so to speak, but of course the line must be drawn somewhere.  Whatever the result, you will have a much better idea of where you stand, and what you have to do to protect your health in the long term.

If your blood sugar measures between 100 mg/dl to 125 mg/dl, the doctor will probably order a follow-up test to eliminate error. This test result indicates “pre-diabetes” and your doctor may want to discuss steps you can take to bring your sugar levels down and prevent diabetes.

If you score 126mg/dl or above, the doctor will want to test you again to eliminate the chance of some anomaly that might have caused an inaccurate reading. If a follow-up test scores the same result, this will confirm that you are diabetic!

Of course it may seem silly to say that if your result on this test is 125mg/dl you don’t have diabetes and at 126 mg/dl you ARE diabetic, but they had to make a cut off point somewhere.

What is important is that if you are in the range 100-125 you need to make changes to your nutrition and exercise habits to get your blood sugar down to healthy levels.

Insulin is a factor too!

When your blood sugar levels spike, your body produces insulin to lower the sugar level. So if your fasting blood sugar test indicates higher than normal blood sugar levels, you can be sure your insulin levels are high as well.

Insulin is a very pro-inflammatory hormone that causes a lot of problems in your body when it is chronically elevated. This is another reason why you would want to get your sugar levels down to what is considered healthy.

Insulin causes inflammation and damage to the endothelial lining of your arteries, which is how the process of atherosclerosis begins. Thus your sugar levels have a direct bearing on the development of heart disease.

Connection with heart disease

If your blood glucose levels are chronically elevated, a process called glycation comes into play, which causes tissues like the heart and blood vessels to lose elasticity and become stiff.

This stiffening process, along with the damage from inflammation, makes you susceptible to heart attacks, high blood pressure and strokes.

To make it really simple and clear, elevated blood sugar=heart disease! This connection is far more important than cholesterol which does not directly cause heart disease. High blood glucose levels are also a factor in many other chronic diseases as well.

The fasting blood sugar test, by measuring how high your blood sugar is on average gives you a clear indication that your risk for heart disease is elevated, which in turn gives you a chance to lower your risk and avoid heart disease, by bringing your blood sugar levels down.

pantethine-capsulesGood cholesterol levels can be achieved easily and naturally using pantethine, which is what I call a heart healthy nutritional supplement.

It is a derivative of vitamin b5 and it’s made up of two molecules of pantothenic acid linked together by what’s called a cysteamine bridge.

It is an intermediate step in the synthesis of  Coenzyme A, which in turn is involved in various enzymatic reactions including the production and oxidation of fatty acids.

pantethine molecule

Pantethine is what’s called the “active” (more biologically available) form of the vitamin b5, but unlike the more well known form calcium pantothenate, it is less stable and will degrade if not refrigerated.

The theory is that since it’s closer biochemically to coenzyme A, it is more beneficial than pantothenic acid. It’s involved in the activation of coenzyme A and helps transport fatty acids across the cell membrane into the mitochondria to be used to make ATP, (a key component in health).

However as you will see it’s benefits go far beyond improving your cholesterol hdl ratio!

How does it work and what does it do?

Biochemistry details aside, the bottom line for the average person is “what does it do?” Dr. Stephen Sinatra has stated that in every type of heart disease, what we find is an energy starved heart! The role of pantethine in cellular energy production is a big part of it’s beneficial effect on heart health.

The heart is a very energy intense organ, and the ability for the cells of the heart to produce  energy in the form of ATP affects every aspect of your heart function, from contraction to the electrical signaling that keeps your heart beating strongly and evenly.

Pantethine is right in the middle of all of this because it is a key player in the production of ATP in the mitochondria of your cells. In plain English, it boosts energy not only to your heart, but all the organs and systems of your body!

It  has been shown (in animal experiments) to lower LDL cholesterol and raise hdl cholesterol, improving the cholesterol hdl ratio, as well as decreasing triglycerides. The ability of pantethine to promote good cholesterol levels is highly beneficial to heart health.

In addition is increases levels of apolipoprotein A1, which is the component of HDL responsible for transporting cholesterol away from the arteries and back to the liver. Pantethine also functions as an anti stress nutrient, due to the fact that it supports the health of your adrenal glands and protects the health of your hormonal system particularly when you are under stress.

Pantethione also protects your brain in several ways. It promotes the synthesis of Coenzyme A (CoA) which in turn is used in the production of the neurotransmitter acetylcholine, which is critical for healthy brain function, and a lack of this neurotransmitter can lead to Alzheimer’s Disease.

It’s positive effect on the synthesis of CoA improves the efficiency of your heart and in turn improves blood flow to the brain. Pantethine has also been shown to be beneficial for the immune system, detoxification, arthritis, and wound healing. It is used also to treat acne, and also for gout and CFS (chronic fatigue syndrome).

So the evidence is that pantethine…

  • Improves hdl cholesterol levels
  • Improves ldl cholesterol level
  • Protects the brain by boosting acetylcholine
  • Improves heart function and blood flow
  • Can be used to treat acne
  • Is helpful in Chronic Fatigue Syndrome
  • Improves detoxification
  • Strengthens the immune system
  • Combats arthritis
  • Can be used to treat gout

How is it taken (form and dosage)

Pantethine as a nutritional supplement is taken orally in capsule form. Clinical research protocols have used as little as 300mg per day with statistically significant result. Levels of 600mg to 900mg have been used in research and yielded very significant reductions in LDL levels for subjects with elevated cholesterol levels. In general though there is little information to use as a guide for precise dosage levels.

Remember that where dosages are concerned, more is not necessarily better. The best course of action would be to use this supplement under the guidance of a complementary physician who can do follow up blood work and determine the correct dosage based on that.

This supplement should work at a relatively low dose, even as low as 5mg to 50mg per day. Start with the lowest dosage and work upwards until you find what works for you.

There are home cholesterol tests that you could use to establish a baseline reference and follow up test would tell you if the pantethine was having an effect. You would have to be careful to account for all the variables in your diet and activity level, and even at that it would not be a “scientifically accurate” result, but enough for you to determine whether pantethine was actually promoting good cholesterol levels.

Side effects

Large amounts of this supplement could potentially block absorption of other b vitamins. It could also cause fatigue, numbness in your hands and feet, or headaches. It’s effect on peristalsis could cause more frequent bowel movements or diarrhea.

The toxicity of this supplement is extremely low, and it has been termed “well tolerated” which is medical jargon for having few side effects. It is not likely that toxicity would be a problem at the dosages that would have benefit.

Brands to look for

Brands I like are:  Jarrow Formulas, Life Extension, and Pure Encapsulations. You really can’t go wrong with these companies when it comes to the quality of the supplements they sell. To be sure there are other good brands, but these are the ones I know of to be top notch.

To Sum Up

This is a supplement that can be helpful in many conditions due to it’s vital role in cellular energy production. Think of it less as something “medicinal” and more as a substance your body needs to create energy that powers all of your biochemical reactions.

Pantethine can be a powerful addition to your nutritional arsenal when it comes to promoting good cholesterol levels, combating heart disease and protecting your brain function. This article should be a starting point for your investigation and use of this fascinating supplement!

cholesterol lowering foods

 

Cholesterol lowering foods have a lot more benefits than just promoting good cholesterol levels. Foods to lower cholesterol often have antioxidant and anti inflammatory benefits as well. These foods will help you lower cholesterol naturally, maintain a stable weight, fight disease, and add healthy years to your life!

Some of these foods you will be familiar with, and some may be knew to you, but the point is that you will have a wide variety of tasty foods to choose from, and they will result in better cholesterol numbers as well as reduced risk of heart disease, cancer, stroke, and diabetes.

Good cholesterol levels can be promoted in many ways, and your diet is a huge factor in what your cholesterol profile looks like. Focusing on cholesterol lowering foods is a great strategy because the reductions in cholesterol numbers will happen automatically just by eating certain foods.

Cholesterol lowering foods:

Foods to lower cholesterol work in several ways:

  • Foods with high fiber
    • Fruits like apples, pears, coconut, guava, grapefruit, berries, figs, apricots
    • Vegetables like greens, sprouts, squash, eggplant, green beans, and peppers
    • Whole oats, beans, legumes, lentils, peanuts
    • Nuts and seeds of all kinds
  • Foods that provide beneficial fats
    • Chicken, turkey
    • Free range grass fed meat, salmon and cold water fish
    • Avacados, olives
    • Nuts, nut butters, seeds, seed butters
  • Foods that provide antioxidant protection
    • Spices like curcumin (curry), cloves, cinnamon, oregano, nutmeg, chilli powder
    • Nuts such as peanuts, hazelnuts, pecans, walnuts, sunflower and pumpkin seeds
    • Onions, garlic, chilli peppers
    • Dark skinned vegetables, fruits like grapes and berries

These are ALL cholesterol lowering foods, and they work in different ways. They all contribute to better nutrition, digestion, and antioxidant status. These are healthy ways to achieve good cholesterol levels, rather than depending on toxic medication that often have severe side effects.

The foods listed above help lower blood sugar, which in turn lowers insulin (a very important aspect of heart health). some cholesterol lowering foods bind with bile acids containing cholesterol and help flush it from the body. They protect blood vessels from the effects of inflammation due to the antioxidants they contain.

This is the most important relationship between cholesterol and diet, not just how much cholesterol is contained in the foods you eat. Blood glucose levels affect your cholesterol profile, so any foods which lower blood sugar are beneficial in promoting good cholesterol levels.

Some of these cholesterol lowering foods also raise HDL! This is especially important because it is the HDL/LDL ratio that determines your risk of heart disease. So raising HDL is critical to protecting your cardiovascular system from the effects of inflammation.

When we talk about foods to lower cholesterol, these are ideally foods in their raw and natural state. Some foods do have to be cooked for safety, but when you can eat foods raw and unprocessed, so much the better.

Good cholesterol levels are generally defined as total cholesterol between 160mg/dl and 180mg/dl, with an HDL level of over 45mg/dl. Cholesterol CAN be TOO low, which is dangerous as well because it is associated with increased risk of serious illness, even heart disease!

The point of all this is that using cholesterol lowering foods to reduce cholesterol levels will allow you to do it naturally, so that your body will optimize it’s cholesterol production rather than using drugs to artificially lower it.

To sum up one again the 3 benefits of cholesterol lowering foods:

  • Foods that provide fiber to bind cholesterol and eliminate it from your body
  • Foods that provide beneficial fats to balance hormones and inflammatory pathways
  • Foods that provide antioxidants benefits to protect against free radicals and oxidative stress

The relationship between cholesterol and diet really depends on the above three factors. A diet that fails to do those things, is associated with high cholesterol levels, because your body is not functioning optimally.

Cholesterol lowering foods can do all of these things and more. They will promote longevity and good health, allowing you to avoid the devastating effects of cardiovascular disease, cancer, stroke, and diabetes. Yes foods to lower cholesterol can do all that, so enjoy them in good health.

HDL cholesterol level is the most important factor in your cholesterol profile. The cholesterol hdl ratio is used to determine your risk of a heart attack or stroke. Low hdl means greater risk, and I will explain the reasons why.

hdl cholesterol levelThe effect of cholesterol on your heart health has been distorted by bad information over the years. This is because pharmaceutical companies want to sell statin drugs, so they influenced doctors to set up guidelines that call for proscribing these drugs for lowering cholesterol levels.

The drugs do not lower cholesterol naturally, they do it by interfering with your body’s natural production of lipids, which is unhealthy and dangerous. What makes cholesterol a problem in your arteries is inflammation and free radicals which oxidize the cholesterol and turn it into hard plaques. Hdl cholesterol prevents this process, and protects you against heart disease.

How to raise increase good cholesterol

We know that HDL cholesterol functions as an antioxidant in the body. This means that it will help prevent LDL cholesterol from turning into dangerous plaques inside your arteries. This is why the cholesterol HDL ratio can predict your risk of heart disease. The higher the HDL cholesterol levels, the lower your risk.

So just how do we increase good cholesterol? We do it by diet, exercise, and using certain nutritional supplements that help boost HDL  levels.

Let’s start with diet! Below are some foods that can help increase good cholesterol:

  • Fatty fish such as salmon, tuna, mackerel, sardines
  • Raw nuts and seeds like walnuts, pecans, almonds, and flaxseeds
  • Whole eggs (yes that’s right…they must be WHOLE eggs)
  • Onions
  • Fresh raw low glycemic vegetables – especially dark leafy greens
  • Oat bran
  • Alcohol – 1 or 2 drinks per day maximum

These foods work in a natural way by giving your body the raw materials such as essential fatty acids it needs to raise  HDL!

Nutritional Supplements

Nutritional supplements can also help you increase good cholesterol

  • Fish oil
  • Pantothenic acid (vitamin B-5)
  • niacin – (vitamin B-3)
  • Gugulipid
  • Coenzyme Q-10
  • Carnitine
  • Vitamin-C
  • Vitamin-D
  • Magnesium
  • Polycosanol
  • Vitamin E-complex
  • Alpha Lipoic Acid
  • N-Acetyl-Cysteine
  • CLA – conjugated linoleic acid

All of these supplements help increase HDL levels, however niacin (B-3) and calcium pantothenate (B-5) are the most effective, so you should focus on them first, and add others if needed.

Exercise to raise your HDL cholesterol level

The best form of exercise is some kind of internal training. This might be circuit weight training, kettlebells, bodyweight exercises, ect. The main principle is the workouts should be brief, intense, and make your heart and lungs work hard.

Naturally, if you are older, or not on good health, you should get clearance from your doctor before engaging in strenuous exercise. You should also work into an exercise program gradually so that your body gets used to it. Never jump right into an intense exercise program. Take time to build up your exercise capacity so that you don’t overdo it.

The PACE program by Dr. Al Sears is an excellent exercise system for this!

Just what are good HDL cholesterol levels?

Remember that the cholesterol HDL ratio is very important. That determines your risk of heart attack. The table below reflects the Amercian Heart Association guidelines:

American Heart Association Guidelines

Desirable Borderline Risk
High Risk
HDL
60 or higher
40 to 59
40 or less (men)
HDL
60 or higher
50 to 59
50 or less (women)

Action steps to raise for your HDL cholesterol level:

  • Get your cholesterol HDL ratio tested so you know what they are to start
  • Work in 3 15 minute sessions of circuit or interval training per week
  • Avoid refined foods if possible – stick to raw fruits and vegetables
  • Get plenty of healthy fats in your daily diet
  • Supplement with niacin (B-3) and calcium pantothenate (B-5) to raise HDL

Your HDL cholesterol level is one of the best predictive markers for heart disease that we know of. HDL cholesterol protects you against heart disease, stroke, cancer, and Alzheimer’s disease. Make it a point to get your HDL cholesterol levels checked, get them into the healthy range and keep them there. Your heart will thank you!

Raise good cholesterol with Coenzyme Q10, and lower inflammatory LDL particles at the same time.  Sure sounds like a win-win situation for heart health, and recent research strongly supports this important role for Co Q10!

coenzyme q10 moleculeLets take a look at this new nutritional weapon against heart disease, and the other health benefits of Coenzyme Q10.

What’s Coenzyme Q10?

Coenzyme Q10 or CoQ10 as it is also referred to, was discovered by Professor Fredrick L. Crane and his research team at the University of Wisconsin–Madison Enzyme Institute in 1957.

The reduced form of CoQ10 was called ubiquinone and was identified as a powerful antioxidant and free radical scavenger, and as we will see…it also has the ability to raise good cholesterol and lower inflammatory LDL.

This fat soluble antioxidant is found in the membrane structure of the mitochondria and is a key player in the electron transport chain which functions as an energy creating mechanism in your cells. The end product of these reactions is the creation of ATP, the primary source of energy for your body.

Because of it’s vital role in cellular energy production CoQ10 is found in highest amounts in the organs and tissue that have the highest energy demands.  Your body can synthesize CoQ10 but you also need to acquire it from your diet and possibly from supplementation as well.

How Do You Get Coenzyme Q10?

You can get CoQ10 in tablet form or as a soft-gel. The softgel form is superior because it’s easier for your body to absorb. The usual dose when used to benefit the heart is from 50 to 150 milligrams. The most effective form is the “reduced” form which is called “ubiquinol.”

Food sources of CoQ10 tend to be from animal sources, such as organ meats like liver, heart, as well as muscle. Again this is because those types of organs and tissues have a high demand for energy, and CoQ10 is a vital component of energy production in both animals and humans.

Here are the top foods sources:

  • Pork heart
  • Pork liver
  • Beef heart
  • Beef liver
  • Chicken liver
  • Chicken heart
  • Sardine
  • Mackerel

If you are a vegan there ARE  vegetable sources of Coenzyme Q10, the best are whole grains, peanuts, wheat germ, broccoli, and spinach. Keep in mind though that these sources are a lot lower in CoQ10 than animal proteins, so if you are trying to make up for a deficiency in Coenzyme Q10 you may need to use a supplement like ubiquinol if you are eating a vegan diet.

Health Benefits of Coenzyme Q10

There are many health benefits of Coenzyme Q10 from protecting yourself from heart disease, to blood sugar control and better energy.  Here is a short list of medical conditions where Coenzyme Q10 can be beneficial:

  • Malignant Melanoma
  • Diabetes
  • Endothelial Dysfunction
  • Heart Disease
  • Alzheimer’s Disease
  • Senile Dementia
  • Hypertension (high blood pressure)

CoQ10 is both an antioxidant and a bio-energetic nutrient, which means it both protects cells against oxidative stress (which robs the cells of energy) and also has a vital role in making the ATP molecule that supplies energy that cells need to maintain and repair themselves.

Coenzyme Q10 and Cholesterol

CoQ10 has beneficial effects on cholesterol profiles because of it’s role as a powerful antioxidant and free radical scavenger.  It’s been established that heart disease results from inflammation and free radical damage to the heart and the arteries through which blood flows.

By fighting oxidative stress and the free radicals it produces, CoQ10 can help prevent the damage to the endothelium and the process of atherosclerosis that causes coronary artery disease. The effect of CoQ10 on cholesterol is that it will raise good cholesterol (HDL) and lower LDL.

Even though we have learned recently that cholesterol does not CAUSE heart disease, it is a FACTOR in atherosclerosis that damages arteries. Coenzyme Q10 has been shown to alter the ratio of HDL to LDL that helps protect against coronary artery disease.

Cardiologists like Dr. Stephen Sinatra have been using Coenzyme Q10 to treat heart disease for many years, and now his colleagues are beginning to embrace this nutrient and add it to their treatment protocols, because of it’s ability to raise good cholesterol and lower inflammatory LDL particles.

Coenzyme Q10 and Statins

Statins, the drugs most often given to people to lower cholesterol have some very serious side effects. Some prominent cardiologists have come out against widespread statin use because the benefits of these drugs are far outweighed by the dangers to health that these drugs pose.

Statins deplete Coenzyme Q10, leaving the body vulnerable to a number of damaging processes that are rooted in oxidative stress and free radical damage. It is for this reason that a number of cardiologists recommend that in cases where statins are used the patient MUST be given Coenzyme Q10 in supplement form to protect against this statin caused deficiency.

The Case for Co Q10

Cardiologists are starting to use it, and in fact it has been used for many years in Japan to treat heart disease. Incidentally the Japanese are the longest lived population in the world, so it seems they know a thing or two about the health benefits of Coenzyme Q10.

The ability to raise good cholesterol with Coenzyme Q10 is the real value of this nutrient in helping to treat and prevent heart disease. Given the fact that heart disease is the number one killer of Americans, Coenzyme Q10 may prove to be one of the most effective strategies to keep your cardiovascular system healthy and extend your life.

By – Eve Pierce

Heart disease is a huge concern in the US at present. On average, 600,000 people per year die in this country as a result or to put it more starkly, 1 in 4 per annum; a quarter of the country’s annual deaths.

healthy-heartIt is America’s most significant killer and incidences of the condition are on the rise. But, for many, the facts of heart disease are shrouded in mystery. What exactly causes it? Is there any way it can it be avoided? Are the causes obvious, or are there causes that are lesser known?

And most importantly; what can be done in terms of lifestyle and dietary change, to ensure that the illness is avoided? For those seeking to promote longevity in their lives, it is vital to address these issues, in order to maintain a healthy heart and to live a long and fulfilling life.

What is Heart Disease?

Considering how often the phrase is used in society, it is often one of the most misunderstood medical terms. Heart disease does not simply refer to heart attack (though coronary disease still remains the most common; killing on average, 385,000 people per annum).

It can refer to a whole range of conditions affecting the heart, including heart rhythm problems and infections. Alarmingly, few Americans are aware of the symptoms; which is a contributing factor to the high rate of death among sufferers. Symptoms include:

  •     Shortness of breath.
  •     Pain in the upper body, particularly in the arms, neck, back or upper stomach.
  •     Cold sweats, dizziness or nausea.
  •     Chest pain.

It is a good idea to be aware of the symptoms, but a far better idea is to be aware of the preventative measures that can be taken to ensure that heart disease never occurs.

Causes of Heart Disease

As might be expected, major contributory factors are diet and lifestyle. A major cause of heart disease has been attributed to foods that are high in polyunsaturated oils and processed carbohydrates; foods which are still sadly all too prevalent in the US. In addition to this, food that is high in processed salt content, and trans fats are considered to be large contributors to heart disease.

Exercise (or lack of) is also a considerable factor, as is smoking. However, there are some lesser known and rarer causes; such as spasms of the arteries caused by certain drugs and medications, trauma to the chest and even other diseases, such as Kawasaki disease.

Recent research has also uncovered other interesting suggestions of lesser known causes, such as the link between cardiovascular disease and baldness in males. However, all experts agree that, with appropriate adjustments to lifestyle and eating habits, heart disease can be avoided by a significant proportion of the US population.

How to Avoid Heart Disease and Promote Longevity

When making lifestyle changes, sometimes it can be difficult to know where to start. When making plans to change your way of living to avoid heart disease, an excellent place to start is with diet. Avoid fried foods and anything that contains trans fats. Start cutting down on processed table salt, which can cause problems for those people with elevated blood pressure

Avoid adding unnecessary amounts of salt to your cooking and avoid eating heavily salted products, such as potato chips and fries. When considering introducing exercise into your life, aim for little and often, at the start, rather than less frequently but more intensively. When you become more fit, you can increase the intensity of your exercise as appropriate.

Experts recommend taking a brisk walk for ten minutes, three times a day; at least five days of the week. Sometimes, introducing this can be as simple as opting to walk to the local store rather than drive there; or choosing to walk the dog three times a day, rather than once. If you are a smoker, try quitting (smokefree.gov has great tips to get you started) and it is also advised to cut down on alcoholic intake.

Healthy Heart; Happy Head

Focus on developing a positive attitude when changing your lifestyle for the better. For those who are used to viewing exercise as unpleasant and fast food and candy as a ‘treat’, having the willpower to make the changes can be tough. Rather than focusing on what you’re missing, think forwards and visualize where you want to be in the future; fit, healthy and heart disease free.

Lowering triglycerides can significantly improve heart health! Your body is an totally integrated system. Knowing the cause of high triglycerides and learning how to reduce your levels will decease your risk of heart disease.

lowering triglyceridesWhile cholesterol is most often blamed for heart disease, recent scientific evidence does not support the theory that cholesterol causes cardiovascular disease. Fully half of all heart attacks occur in patients who have what are considered normal cholesterol levels. The evidence more strongly points toward triglycerides.

Triglycerides are a major factor in heart disease. An estimate two thirds of heart disease cases are at least partly a result of abnormal triglyceride levels.

There are two types of high triglycerides:

  • Familial (genetic) – usually over 400mg/dl this is not
    thought to be a cause of heart disease
  • Insulin resistant – usually 150-400mg/dl this is dangerous,
    associated with pre-diabetes and increased risk of heart disease

What are triglycerides and why are they important?

Triglycerides are lipids that are made from fats or carbohydrates you eat and are stored in the body. The higher their levels, the greater your risk for heart disease, which is why lowering triglycerides is so critical for your cardiovascular health.

Here is why elevated triglycerides are dangerous, and why lowering triglycerides is so important.

  • They are deposited in various organs including the heart
  • They can alter gene expression and increases heart disease
  • They can cause insulin resistance leading to diabetes
  • They can accumulate on artery walls causing plaque buildup
  • They thicken blood causing strokes and other circulatory
    problems
  • They contribute to abdominal obesity

What is a normal triglyceride level?

Before you go about lowering triglycerides, you need to check your levels to get a baseline so that you can tell how effective your efforts to lower them are!

The guidelines of the American Heart Association recommend that a normal triglyceride level is under 149 mg/dl.

However the Life Extension Foundation recommends an even lower level of 80-100 mg/dl measured in a fasting state.

The “fasting state” is when you have not eaten for at least 12 hours.

Unlike cholesterol, you really don’t have to worry about triglycerides going too low, so lowering triglycerides will have positive benefits for your health.  Doing the right things will bring the levels down naturally, to what is optimal for you.

Cause of high triglycerides

Just what causes these levels to become too high?

There are several factors:

  • Eating carbohydrates that raise your blood sugar rapidly
  • Problems with carbohydrate metabolism
  • Heavy drinking
  • Insulin resistance (poor insulin sensitivity)
  • A diet that consists of over 60% carbohydrate
  • Smoking
  • Lack of exercise – low physical activity
  • Obesity
  • Metabolic Syndrome
  • Kidney disease
  • Certain prescription medications (estrogen, birth control pills, tamoxifen, steroids, beta-blockers, and diuretics)

Lowering triglycerides

Lowering triglycerides really comes down to two things, restricting sugars, and getting regular exercise. Of course there is more to it than that, but those are the two most effective things.

Most people eat too many refined carbohydrates, and that is the cause of high triglycerides.

A “low glycemic diet” high in fiber will help in lowering triglycerides. This is because fiber slows down the entry of sugars into the bloodstream. Rapid entry of sugar into the bloodstream causes insulin to rise, and this promotes inflammation which in turn causes triglyceride levels to go up!

Nutritional supplements such as circumin, and green coffee extract, can also help by lowering inflammation, and helping the body manage blood sugar levels more efficiently.

Exercise also helps in lowering triglycerides  because it increases insulin sensitivity, maintains lean muscle, and mobilizes fatty acids to be burned for energy.

Below are some short simple steps for lowering triglycerides:

  • Limit your carbohydrates to mostly fresh vegetables – go easy on fruits
  • Eat what is known as a low glycemic diet
  • Avoid over consuming grains, and eating sweets
  • Eat lean proteins
  • Use nutritional supplements as you need them
  • Get some kind of brisk exercise each day

That’s pretty much it! Lowering triglycerides willboost heart health and improve the health of your entire cardiovascular system.  It’s probably the best things you can do to put yourself on a path to better health!

Cholesterol lowering exercise has three basic functions, to lower triglycerides and LDL, lower blood sugar, and to raise HDL cholesterol. Any form of exercise that does those three things will help.

kettlebell exerciseExercise and cholesterol are inversely related. This simply means that the more exercise you do, the more you can reduce your cholesterol levels, provided you are exercising correctly.

Most of the studies on exercise and cholesterol were done on aerobic exercise like  running or jogging. These activities are reported to lower LDL between 5-10%, and raise HDL cholesterol from 3-6%. These are estimates in a range of results, so your individual results may be more or less than this.

The important thing is that any activity is beneficial, and you have to modify the type of cholesterol lowering exercise to suit your individual circumstances. For instance, if you have injuries or orthopedic problems, you might want to do some kind of exercise in a pool that is non impact like swimming, or other water exercise. Even walking is preferable to being idle.

With that said, lets look at what types of cholesterol lowering exercise is best  and what makes these forms of exercise so effective.

Aerobic Exercise

This form of exercise utilizes oxygen as you go and will raise HDL cholesterol. It is the most studied form of exercise to help prevent heart disease. However I would caution that aerobics can be overdone, and have negative effects on your hormonal system if you do them too long at a slow steady pace because it raises cortisol which is a stress hormone that is bad for the heart.

Interval Training

Interval training is a great compromise as it can increase heart and lung function, but will not negatively effect your hormonal system. Interval training utilizes short intense bursts of exercise followed by a slowdown or rest period.

Heavyhands and kettlebell training are two examples of exercise that use interval training rather than steady state cardiovascular exercise. Intervals are not specific to the exercise device or equipment, rather it is exercise pace and timing that makes interval training so effective.

A good example of this is the PACE program of Dr. Al Sears M.D. This program utilizes a form of interval training to raise peak fitness and prepare the heart and lungs for occasional bursts of intense activity.

It is the stress of sudden intense activity in an unconditioned person that is most likely to trigger a heart attack, so getting the body used to handling this stress can protect against it.

Kettlebells

Kettlebell training is my favorite form of cholesterol lowering exercise,  because it combines strength training with cardiovascular exercise at the same time. It will help maintain muscle mass, which will lower triglycerides by keeping blood sugar low.

As I mentioned previously, you can do interval training  very effectively with kettlebells but you have to be cautious and make sure you use proper technique as these exercise implements can be tricky to handle.  I strongly suggest you either get professional instruction, or purchase a good book or DVD that teaches how to do these exercises properly.

Kettlebell training can help raise HDL cholesterol because of the cardiovascular aspects of this exercise. Since you cannot adjust the weight of a kettlebell, you will need to come up with creative ways to make the exercises more intense and physically demanding. This form of training seems to be very effective for burning stored bodyfat , which is important when exercising for heart health.

The Bottom Line

Cholesterol lowering exercise can range from light simple exercise like walking to intense exercise like intervals or kettlebell training. The most important thing is that it fits your physical limitations, lifestyle, and individual needs.

Start easy and keep it simple, but get moving and make regular exercise a part of your life. You will look and feel better, and will lower cholesterol naturally.

The benefits of policosanol are it’s ability to lower cholesterol naturally.  It is effective in lowering LDL cholesterol and can also help raise HDL cholesterol. Since there are few policosanol side effects, it is considered to be very safe as well as effective.

benefits of policosanolThere is growing interest in this nutraceutical among holistically oriented practitioners and patients because some experts feel it can replace statin drugs which have severe side effects.

What is It and How Does It Work?

Policosanol is one of a number of natural cholesterol lowering supplements. It is extracted from sugar cane. It is made up of octacosanol which is a “long chain fatty alcohol” and several other long chain fatty alcohols. It works by preventing the synthesis of cholesterol, but in a way that is different from statin drugs.

It doesn’t block the HMG-CoA enzyme the way “statin” cholesterol-lowering drugs do, but the precise way that it works is not understood. It does not seem to have the negative effects on energy metabolism that statins do. The standard recommended dosage for policosanol is 5-20 mg/day.

Benefits of Policosanol

The main benefit of this supplement is it’s ability to lower cholesterol naturally. Other benefits are:

  •     Helps prevent the formation of artery lesions
  •     Inhibits the formation of blood clots
  •     Reduces levels of a blood vessel-constricting eicosanoid called Thromboxane
  •     Stops cell overgrowth which can cause narrowing of your arteries
  •     Is effective in lowering LDL cholesterol
  •     Can raise HDL cholesterol
  •     Enhances the effect of exercise
  •     Inhibits the oxidation of LDL cholesterol which decreases inflammation

Effects on Exercise

It has been shown in studies to increase stamina and oxygen uptake during exercise. It is apparently used in muscle tissue as an energy substrate and positively enhances energy production. It’s initially stored in the liver but eventually finds it’s way into muscle tissue, enhancing metabolic activity.

Studies were done in Japan with 10 mg per day , which increased endurance, oxygen uptake and aerobic capacity, as measured on treadmill ECG testing. It also reduced ischemia, improved reflexes, and increased muscle strength.

Additional Benefits of Policosanol

In postmenopausal women and people over 60 who are at increased risk for heart disease, it decreased LDL cholesterol by 25% and lowered total cholesterol by 17%. This was achieved at a dosage of 10 milligrams per day.

At the 20 milligram per day dosage level, it gave people with intermittent claudication (muscle pain, cramps, and fatigue while walking) relief, and allowed them to walk greater distances with less pain. This shows that policosanol has therapeutic value that goes beyond beneficial effects on cholesterol.

Policosanol Side Effects

Along with the benefits of policosanol there are a few side effects that were reported in clinical trials.

The main side effect reported was weight loss, and the other side effect was abdominal pain, however this effect was also reported in the people who were not taking it, so it is not clear that it had anything to do with policosanol being taken.

Policosanol is very safe. Rats given dosages that were 1724 times what a human dose would be, showed no signs of toxicity. There was also no carcinogenic (cancer) activity associated with it. All tolled the side effects of are for all intents and purposes 100% positive, with no proven negative effects at all!

Drug Interactions

Although policosanol is not a drug, people may be concerned about it causing problems for them if they are on medications. However, there is no evidence that it causes any problems when used with drugs that are being taken.

There is evidence that it can enhance the effects of propranol (a blood pressure lowering drug), so caution should be taken with this combination.

There haven’t been any studies done combining it with specific drugs or types of drugs, however there was NO reported adverse effects when using policosanol along with the following:

  • Anti-coagulents (blood thinners)
  • Beta-blockers
  • Calcium antagonists
  • Diuertics
  • Vasodilators
  • Thyroid hormones
  • NSAIDs
  • Antidepressants
  • Digoxin
  • Ulcer drugs
  • Meprobamate
  • Anti-anxiety drugs
  • Neuroleptics

Does Not Inhibit Sexual Function

One of the best things that can be said about policosanol is that it does not inhibit sexual function like statin drugs can, even at high dosages used in animal experiments. Studies with male rats showed that it increased sexual activity, but the mechanism that caused this wasn’t clear. Thus when it’s used in normal amounts there is NO negative effect on a person’s sex life!

Safe, Effective, and Natural

There are many natural alternatives to statin drugs out there for optimizing your cholesterol profile.  Research these carefully and coordinate your efforts with an integrative cardiologist who understands how to use nutritional approaches to promote heart health.

Benefits of policosanol are that it is one of the safest and most effective cholesterol lowering supplements available and it compares very favorably with “statin” drugs while at the same time having none of the side effects or toxicity.