artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

Citrus BergamotCitrus Bergamot is the latest natural supplement for lowering cholesterol levels and can also lower blood sugar as well. This new food supplement has taken the medical world by storm, even being used in place of statin drugs in some cases.

Truth be known, it’s an interesting compound but has many varied effects. It’s ability to block the synthesis of cholesterol means that it could cause problems in some people who’s cholesterol levels are too low to start with.

It is beneficial in other ways though, so it’s definitely something you need to discuss with an integrative cardiologist, if you are attempting to use it as a means of lowering cholesterol levels.

What is Citrus Bergamot?

Citrus Bergamot is a small sized tree that will blossom during winter. In terms of bitterness, it is less bitter than lemon but more than grapefruit. It is used as an ingredient in Earl Grey Tea. The juice of this plant is not consumed, but is used as a treatment for malaria, and the oil is used for aromatherapy.

A fragrant orange sized yellow green citrus fruit that is grown commercially in the Calabria region of Southern Italy. It is grown also in the southern part of France, as well as the south of Turkey.

The essential oil of Bergamot is a dark greenish-brown in color and is extracted in Cote d’Ivorie. It is grown in Antalya Turkey for use in marmalade.

Unlike other citrus fruits, Bergamot has very large amounts of polyphenols. Two of those compounds Melitidin, and Brutieridin, block the synthesis of cholesterol in the liver in much the same way statin drugs do.

It also has a similar effect to grapefruit in that it can affect the way your body metabolizes various pharmaceutical drugs.

How does it work?

Bergemot reduces the amount of triglycerides and cholesterol you would ordinarily absorb through meals. It also reduces the biosynthesis of cholesterol in the body. It also helps glucose get into cells which is beneficial for diabetics.

It blocks the HMG CoA Reductase Enzyme, which is what statin drugs do. It contains substances called polyphenolic flavanoids that suppress cholesterol production in much the same way that statins do, but it works in a different way that does not seem to deplete coenzyme Q10.

There are three main modes of action:

  • Blocks the HMG CoA Reductase Enzyme
  • Works on insulin receptors to improve shuttling of glucose into cells
  • Blocks cholesterol absorption in the intestine similar to plant sterols

What are some of the benefits of Citrus Bergamot?

  • It promotes fat burning and improves blood sugar control. This helps combat obesity and promotes weight loss.
  • It combats arterial stiffness due to it’s effect on sugar metabolism, and the benefits of the flavinoids it contains.
  • Can reduces LDL and triglycerides and increase HDL cholesterol
  • Helps in lowering blood pressure
  • Bergamot shows anti-tumor action and may be effective in combating neuroblastoma and other metastic cancers
  • It demonstrates anti-inflammatory and antioxidant properties that improve endothelial function

How is Bergamot taken?

When used for it’s cholesterol lowering effect, it would be taken in capsule form at appropriate doses, and this is where things get tricky. The medical profession knows a lot about drugs and the dosages that should be given, but not very much about vitamins, nutraceuticals, and herbs.

Citrus Bergamot capsulesDosage recommendations for this supplement are anecdotal and not the result of carefully controlled trials and years of clinical case studies and experience. Great care should be taken with this supplement, as it does mimic the effects of statin drugs, and thus could have some of the same side effects.

Given this fact, I think it’s wise to seek the advice of a complementary physician, who has knowledge of alternative treatments.

In research conducted at the Scripps Integrated Medicine Conference in San Diego California, in January 2012, they used 1,000 milligrams per day and got an average reduction in total cholesterol levels of 29%, a 36% reduction in LDL, and increase HDL cholesterol by 40%!

Reductions in triglycerides of 30%, and blood glucose of 20% on average were also noted. From this result the researches concluded that Citrus Bergamot extract at a dosage of 1,000 milligrams per day was an effective substitute for statin drugs for lowering LDL cholesterol, and also treating metabolic syndrome.

In Summary:

Citrus Bergamot is an interesting compound with some powerful effects on cholesterol metabolism, blood sugar control, and metabolic syndrome. It has demonstrated anti-tumor effects as well. However due to it’s statin like mode of action, I would very strongly suggest that you use it ONLY under the direction of a doctor who is knowledgeable about alternative medicine.

The doctor can help you determine if it’s right for you, and if so, how to arrive at a safe and effective dosage.

Research references:

Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Fitoterapia. 2010 Sep;81(6):453-61. doi: 10.1016/j.fitote.2010.01.013. Epub 2010 Jan 20.
Neuropharmacology of the essential oil of bergamot.

Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8.
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.

Fitoterapia. 2014 Jun;95:83-92. doi: 10.1016/j.fitote.2014.02.009. Epub 2014 Mar 2.
Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models.

PLoS One. 2013 Apr 16;8(4):e61484. doi: 10.1371/journal.pone.0061484. Print 2013.
Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.

The MTHFR gene is a hidden culprit in heart disease and explains much in the reasons why cholesterol numbers don’t tell you what your real risk for heart disease is. Understanding how this gene defect affects your good cholesterol levels and how to treat it is essential to protecting yourself from heart attacks.

MTHFR geneWhat is the MTHFR Gene?

This gene is responsible for operating what are called “methylation pathways” that involve your body’s ability to convert certain substances into their reduced or active form. If this gene is defective in your body, these vitally important methylation processes cannot be completed properly, and certain substances (vitamins and amino acids) can’t be absorbed by your body and you develop deficiencies.

Some of these substances are:

  • vitamin b-12
  • folic acid
  • cystiene

In the case of b-12 and folic acid, these substances are converted to their active forms of methylfolate and methylcobalamin. These active forms are what your body can actually use, and so if you can’t convert them properly, you end up with a deficiency.

Cystiene is converted to the toxic amino acid homocysteine and then to methionine. If your methylation pathways are not working properly due to the MTHFR gene defect, then you end up with an accumulation of homocystiene which is highly inflammatory and causes damage to your arteries.

How is Your Good Cholesterol Level Affected?

HDL-C also called the “good cholesterol,” can be effectively lowered by a certain type of MTHFR gene defect called: C677T polymorphism.  Since HDL is protective and lowers your risk of heart disease, this gene defect can raise your risk by lowering your good cholesterol level.

There are several variants of this gene defect, and they affect cardiovascular risk in different ways, but it’s important to be aware of their impact so that you can protect yourself. Remember that 50% of heart attacks occur in people who have what’s considered normal cholesterol levels.

The affect of the MTHFR gene is seen by many researchers as the missing piece of the puzzle in trying to determine why this is so. With this information you can go about protecting yourself by applying this new knowledge and lowering your risk not only for heart disease, but also for other chronic diseases that are caused by inflammation.

What Other Problems Can This Lead To?

A defect in the MTHFR gene can also result in increase risk for the following diseases:

  • Cancer
  • Stroke
  • Fibromyalgia
  • Polyneuropathy

How Do You Know if You Have it?

This is a very important question, because once you detect this, then you can guard against it’s effects. The most simple test you can do is to eat asparagus and note if your urine has a strong odor in the hours following your meal.

If this odor is present when you urinate, (you can’t miss it), then you can be sure that you do in fact have a defect (called a polymorphism) in the way your MTHFR gene operates. There are also lab tests that your doctor can do to detect this problem.
It may be necessary to have formal lab tests done so that this problem can be medically verified. It’s also important because your doctor has to order it for your insurance to cover it. The best and most responsible advice I can give you is to go through your doctor and get tested for this.

Fortunately there are ways to treat this problem, that will work and help to protect your health, but of course the first step is to determine whether you have it or not, and your doctor can order the tests to confirm it.

What Can I Do?

A defect in the MTHFR gene results in failure to operate certain methylation pathways and convert amino acids properly. However, forms of critical b-vitamins, vitamin B-12, and Folic acid, in their “active” forms, which means they do not have to be converted or methylated, CAN be absorbed by your body and help ensure these critical chemical reactions happen as they are supposed to.

Thus instead of taking folic acid, you would take “methyl-folate.” Instead of taking vitamin B-12 (cyanocobalamin) you would take “methylcobalamin.”

There are other substances that can help. They are called “methyl donors” because they donate or provide what’s called a “methyl group” to help the chemical reaction complete properly. There are foods that contain “methyl donors,” such as garlic, onions, avocadoes, ect.

There are also nutritional supplements such as trimethylglycine, and SAMe, as well as special formulations that contain combinations of these methyl donors to help provide what your body needs to do these conversions properly.

None of these substances are drugs, nor are they prohibitively expensive. However, most mainstream doctors do not know about them, nor about defects in the MTHFR gene, and so you may have to search for a physician that is up on the latest genetic research, that can help you safely manage this problem.

The website I recommend is:

http://mthfr.net/

which is a website run by Dr. Benjamin Lynch. There is a wealth of information on this website regarding methylation issues and the MTHFR gene. If you have this gene defect, I would highly recommend that you visit this website and educate yourself.

You can also click on this video:

to learn more about this topic, and start arming yourself with powerful information that will allow you to protect yourself against heart disease, cancer, strokes, Alzheimers, and other effects of methylation problems.

My reasons for delving into this topic is that it fills in the missing information that cholesterol numbers leave out. The effects of this gene defect on your good cholesterol level is probably one of the main reasons for the increased risk of heart disease.

Defects in the MTHFR gene are one of the most significant drivers of chronic disease, and by knowing if you carry this defect, you can takes very strong steps to protect your health and to live better and longer.

references:

Cardiovasc Diabetol. 2012 Oct 8;11:123. doi: 10.1186/1475-2840-11-123.
Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels.

J Atheroscler Thromb. 2009;16(6):815-20. Epub 2010 Jan 9.
Association of C677T polymorphism in MTHFR gene, high homocysteine and low HDL cholesterol plasma values in heterozygous familial hypercholesterolemia.

J Hum Genet. 2001;46(9):506-10.
An association of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism and common carotid atherosclerosis.

 

Soluble fiber for cholesterol is another safe and healthy way to lower cholesterol naturally, which lowers your risk of heart disease. Using fiber to lower cholesterol is a safer alternative to toxic drugs, besides which foods high in fiber have many other health benefits.

soluble fiber for cholesterFoods high in fiber have an important function in your body, and help to lower your risk of several chronic health conditions. Such fiber rich foods should be included in your diet on a daily basis.

Soluble means that your body can break them down, as opposed to insoluble which means that they pass through your digestive system without being broken down.

What foods contain soluble fiber for cholesterol?

Here is a short list of foods high in fiber.

  •     Psyllium husks
  •     Peas, beans, lentils
  •     Oats, oat bran, wheat bran,
  •     Broccoli, carrots, squash, potatoes, Zucchini
  •     Apples, oranges, tangerines, plums, strawberries, blackberries, apricots

There are more comprehensive lists of foods high in fiber online, but the above list gives you an idea of common foods that you can include in your diet to lower cholesterol naturally.

How do foods high in fiber work?

Research studies have established a positive correlation between dietary fiber and lowered cholesterol levels. There are 3 mechanisms that possibly explain this lowering effect:

  • Preventing cholesterol to be re-absorbed from bile sales and causing more of it to be excreted by elimination (feces)
  • Lowered glycemic response and reduced stimulation of cholesterol synthesis in the liver
  • Fermentation effects of soluble fiber affect bile salts and cut down on re-absorption in a way that is not well understood by science

Excess cholesterol that is not used by the body to synthesize hormones or other important functions is combined with bile acids in your large intestine, is recycled through your liver, and ends up back in your bloodstream.

Foods high in fiber can bind with the cholesterol and help transport it out of your body when you move your bowels. This is part of the way that foods high in fiber can lower cholesterol naturally, rather than using statin drugs that have dangerous side effects.

Remember as well that these sources of fiber only work optimally when you are well hydrated. Water is essential to getting the maximum benefits from fiber on your diet, so make a point to consume plenty of clean pure water throughout the day.

Using fiber to lower cholesterol does work and has been shown to be effective in well conducted studies. The role of soluble fiber for cholesterol has been known for years, but the public has only recently been made aware of it’s benefits.

You could say that using soluble fiber for cholesterol is the most natural way to optimize your cholesterol levels and fiber has other health benefits as well as it’s effect on blood lipids. Better function of your gastrointestinal system (gut) improves health across the board, and fiber has been shown to be beneficial to improving levels of pro-biotic bacteria in the colon.

Daily Recommended Amounts

The USDA recommends 14 grams of fiber for every 1,000 calories consumed for healthy adults. This works out to about 25-30 grams of fiber per day. The average for adults in the United States is approximately 15 grams.

Increased intake of fiber to lower cholesterol has also been associated with a lower risk of cancer, stroke, Alzheimer’s disease, and diabetes, as well as heart disease. Foods high in fiber thus have many benefits beyond helping to optimize cholesterol levels.

Soluble fiber for cholesterol is one of the most important strategies for maintaining a healthy cholesterol profile. Try working these soluble fiber foods into your diet, and you will automatically lower your risk of heart disease!

Soluble fiber for cholesterol – scientific references:

Food Funct. 2010 Nov;1(2):149-55. doi: 10.1039/c0fo00080a. Epub 2010 Sep 30. Mechanisms underlying the cholesterol-lowering properties of soluble dietary fibre polysaccharides.
Gunness P, Gidley MJ.

Am J Clin Nutr. 1999 Jan;69(1):30-42. Cholesterol-lowering effects of dietary fiber: a meta-analysis. Brown L, Rosner B, Willett WW, Sacks FM.