artichoke-leaf-extract

Artichoke leaf extract capsules

Did you know that better heart health and lower cardiovascular risk can be had with two natural products that you can buy right over the counter? Well it’s true! Artichoke extract and pantethine are what we are talking about, and it can help you cut your risk of heart disease without dangerous side effects.

Interested? Well then read on…

Millions of people use the popular statin drugs to lower cholesterol but heart disease still continues to be the number one killer of Americans. Statins lower LDL cholesterol and inflammation while raising hdl but they have serious side effects that can dramatically lower the quality of life and put you at risk for serious health complications. One area where statins fall short is raising HDL levels. They don’t elevate HDL enough to significantly improve your HDL LDL ratio.

Statins can also raise your risk for rhabdomyolysis: (muscle breakdown), kidney damage, and even diabetes. This is due to it’s interference in the biochemical pathways which bio-synthesize both cholesterol and coenzyme Q10, which your body needs to help create energy from the foods you eat in order to power the cells of the heart.

Thus statins not only commonly cause muscle pain and weakness, but can also ironically increase the risk for cardiomyopathy which is muscle damage to the heart!

While there are certain people for whom the risk of statins is justified by their effectiveness, the vast majority of people would likely be better off with natural alternatives, and there are two good ones we have access to, pantethine and artichoke extract. These two supplements or “nutraceuticals” as they are sometimes called, can lower LDL AND raise HDL safely and naturally without the risks of serious side effects.

Enter Artichoke Extract…

An extract from artichoke leaves can raise your levels of HDL, while pantethine which is an analog of vitamin b-5 can lower LDL without causing deficiency of coenzyme q10 (as statins do). The use of these two compounds together has been shown to reduce by up to 11% the risk of heart disease. Pretty powerful stuff for two natural substances!

Artichokes which are actually considered to be in the “thistle’ family contain powerful substances called flavonoids that can lower LDL levels and increase HDL. The flavonoids act as antioxidants, preventing the oxidation of LDL particles in your arteries. In addition artichoke extract can increase your levels of bile acids, which help remove cholesterol from the body.

The clinical results with artichoke extract were based upon an intake of 1,800 mg/day of dry artichoke leaf extract for 6 weeks. This resulted in an 18.5% reduction in total cholesterol, with an improvement in the HDL/LDL ratio. It was also shown to cause an average of over 36% increase in endothelial function (the layer of cells that line the arteries) which also helps to prevent heart disease.

Next Up – Pantethine…

Pantethine lowers LDL levels without reducing coenzyme q10. It does this by inceasing the breakdown rate of serum cholesterol and reducing the rate of cholesterol synthesis. Pantethineis an energy molecule that helps increase fat burning in the body.

It also improves the ratio of HDL to total cholesterol which has a protective effect on your artery walls, reducing plaque formation and lesions in the aorta and coronary arteries.

A four month study was undertaken where the dosage of pantethine was 600mg/day for the first eight weeks and then a higher dose of 900 mg/day for the second eight weeks. This resulted in a modest decrease of LDL with a slight increase in coenzyme q10, unlike statin drugs.

When you consider that every reduction of 1% in LDL levels equals a 1% reduction in heart disease risk, pantethine significantly reduces the risk of heart attack by 11%. This is a very significant result and more reason to include pantethine in your supplement regimen.

In Summary…

All of us are at risk for heart disease as we age, and the primary issue in that risk is elevations in inflammatory LDL particles and low HDL levels. Many of the
patients put on statin drugs stop taking them because of the severity of the side effects, leaving them vulnerable to risk of heart disease once more. However the
combination of pantethine and artichoke extract can help lower LDL and raise protective HDL without the side effects that characterize statin use.

People who are at low risk may be able to achieve effective protection just by using these natural compounds rather than statins drugs. For people who have
extremely high LDL and/or very low HDL, a combination of low dose statins AND natural compounds like pantethine and artichoke extract may be the ideal
combination to avoid side effects AND effectively decrease the risk of heart disease.

As always, any therapy whether drug based OR natural that is intended to protect against heart disease should be managed by your doctor, possibly with the help of
a nutritionist or other wellness professional who is well versed in natural healing therapies, nutrients, and nutraceuticals.

Medical References:

Atherosclerosis. 1984 Jan;50(1):73-83.
Controlled evaluation of pantethine, a natural hypolipidemic compound, in patients with different forms of hyperlipoproteinemia.
Gaddi A, Descovich GC, Noseda G, Fragiacomo C, Colombo L, Craveri A, Montanari G, Sirtori CR.

Plant Foods Hum Nutr. 2015 Aug 27. [Epub ahead of print]
Pharmacological Studies of Artichoke Leaf Extract and Their Health Benefits.
Salem MB1, Affes H, Ksouda K, Dhouibi R, Sahnoun Z, Hammami S, Zeghal KM.
Int J Food Sci Nutr. 2013 Feb;64(1):7-15. doi: 10.3109/09637486.2012.700920. Epub 2012 Jun 29.
Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial.
Rondanelli M1, Giacosa A, Opizzi A, Faliva MA, Sala P, Perna S, Riva A, Morazzoni P, Bombardelli E.

Citrus BergamotCitrus Bergamot is the latest natural supplement for lowering cholesterol levels and can also lower blood sugar as well. This new food supplement has taken the medical world by storm, even being used in place of statin drugs in some cases.

Truth be known, it’s an interesting compound but has many varied effects. It’s ability to block the synthesis of cholesterol means that it could cause problems in some people who’s cholesterol levels are too low to start with.

It is beneficial in other ways though, so it’s definitely something you need to discuss with an integrative cardiologist, if you are attempting to use it as a means of lowering cholesterol levels.

What is Citrus Bergamot?

Citrus Bergamot is a small sized tree that will blossom during winter. In terms of bitterness, it is less bitter than lemon but more than grapefruit. It is used as an ingredient in Earl Grey Tea. The juice of this plant is not consumed, but is used as a treatment for malaria, and the oil is used for aromatherapy.

A fragrant orange sized yellow green citrus fruit that is grown commercially in the Calabria region of Southern Italy. It is grown also in the southern part of France, as well as the south of Turkey.

The essential oil of Bergamot is a dark greenish-brown in color and is extracted in Cote d’Ivorie. It is grown in Antalya Turkey for use in marmalade.

Unlike other citrus fruits, Bergamot has very large amounts of polyphenols. Two of those compounds Melitidin, and Brutieridin, block the synthesis of cholesterol in the liver in much the same way statin drugs do.

It also has a similar effect to grapefruit in that it can affect the way your body metabolizes various pharmaceutical drugs.

How does it work?

Bergemot reduces the amount of triglycerides and cholesterol you would ordinarily absorb through meals. It also reduces the biosynthesis of cholesterol in the body. It also helps glucose get into cells which is beneficial for diabetics.

It blocks the HMG CoA Reductase Enzyme, which is what statin drugs do. It contains substances called polyphenolic flavanoids that suppress cholesterol production in much the same way that statins do, but it works in a different way that does not seem to deplete coenzyme Q10.

There are three main modes of action:

  • Blocks the HMG CoA Reductase Enzyme
  • Works on insulin receptors to improve shuttling of glucose into cells
  • Blocks cholesterol absorption in the intestine similar to plant sterols

What are some of the benefits of Citrus Bergamot?

  • It promotes fat burning and improves blood sugar control. This helps combat obesity and promotes weight loss.
  • It combats arterial stiffness due to it’s effect on sugar metabolism, and the benefits of the flavinoids it contains.
  • Can reduces LDL and triglycerides and increase HDL cholesterol
  • Helps in lowering blood pressure
  • Bergamot shows anti-tumor action and may be effective in combating neuroblastoma and other metastic cancers
  • It demonstrates anti-inflammatory and antioxidant properties that improve endothelial function

How is Bergamot taken?

When used for it’s cholesterol lowering effect, it would be taken in capsule form at appropriate doses, and this is where things get tricky. The medical profession knows a lot about drugs and the dosages that should be given, but not very much about vitamins, nutraceuticals, and herbs.

Citrus Bergamot capsulesDosage recommendations for this supplement are anecdotal and not the result of carefully controlled trials and years of clinical case studies and experience. Great care should be taken with this supplement, as it does mimic the effects of statin drugs, and thus could have some of the same side effects.

Given this fact, I think it’s wise to seek the advice of a complementary physician, who has knowledge of alternative treatments.

In research conducted at the Scripps Integrated Medicine Conference in San Diego California, in January 2012, they used 1,000 milligrams per day and got an average reduction in total cholesterol levels of 29%, a 36% reduction in LDL, and increase HDL cholesterol by 40%!

Reductions in triglycerides of 30%, and blood glucose of 20% on average were also noted. From this result the researches concluded that Citrus Bergamot extract at a dosage of 1,000 milligrams per day was an effective substitute for statin drugs for lowering LDL cholesterol, and also treating metabolic syndrome.

In Summary:

Citrus Bergamot is an interesting compound with some powerful effects on cholesterol metabolism, blood sugar control, and metabolic syndrome. It has demonstrated anti-tumor effects as well. However due to it’s statin like mode of action, I would very strongly suggest that you use it ONLY under the direction of a doctor who is knowledgeable about alternative medicine.

The doctor can help you determine if it’s right for you, and if so, how to arrive at a safe and effective dosage.

Research references:

Fitoterapia. 2011 Apr;82(3):309-16. doi: 10.1016/j.fitote.2010.10.014. Epub 2010 Nov 4.
Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Fitoterapia. 2010 Sep;81(6):453-61. doi: 10.1016/j.fitote.2010.01.013. Epub 2010 Jan 20.
Neuropharmacology of the essential oil of bergamot.

Int J Cardiol. 2013 Dec 10;170(2):140-5. doi: 10.1016/j.ijcard.2013.08.125. Epub 2013 Sep 8.
Bergamot polyphenolic fraction enhances rosuvastatin-induced effect on LDL-cholesterol, LOX-1 expression and protein kinase B phosphorylation in patients with hyperlipidemia.

Fitoterapia. 2014 Jun;95:83-92. doi: 10.1016/j.fitote.2014.02.009. Epub 2014 Mar 2.
Effect of Citrus bergamia juice on human neuroblastoma cells in vitro and in metastatic xenograft models.

PLoS One. 2013 Apr 16;8(4):e61484. doi: 10.1371/journal.pone.0061484. Print 2013.
Mechanisms underlying the anti-tumoral effects of Citrus Bergamia juice.

Raise good cholesterol with Coenzyme Q10, and lower inflammatory LDL particles at the same time.  Sure sounds like a win-win situation for heart health, and recent research strongly supports this important role for Co Q10!

coenzyme q10 moleculeLets take a look at this new nutritional weapon against heart disease, and the other health benefits of Coenzyme Q10.

What’s Coenzyme Q10?

Coenzyme Q10 or CoQ10 as it is also referred to, was discovered by Professor Fredrick L. Crane and his research team at the University of Wisconsin–Madison Enzyme Institute in 1957.

The reduced form of CoQ10 was called ubiquinone and was identified as a powerful antioxidant and free radical scavenger, and as we will see…it also has the ability to raise good cholesterol and lower inflammatory LDL.

This fat soluble antioxidant is found in the membrane structure of the mitochondria and is a key player in the electron transport chain which functions as an energy creating mechanism in your cells. The end product of these reactions is the creation of ATP, the primary source of energy for your body.

Because of it’s vital role in cellular energy production CoQ10 is found in highest amounts in the organs and tissue that have the highest energy demands.  Your body can synthesize CoQ10 but you also need to acquire it from your diet and possibly from supplementation as well.

How Do You Get Coenzyme Q10?

You can get CoQ10 in tablet form or as a soft-gel. The softgel form is superior because it’s easier for your body to absorb. The usual dose when used to benefit the heart is from 50 to 150 milligrams. The most effective form is the “reduced” form which is called “ubiquinol.”

Food sources of CoQ10 tend to be from animal sources, such as organ meats like liver, heart, as well as muscle. Again this is because those types of organs and tissues have a high demand for energy, and CoQ10 is a vital component of energy production in both animals and humans.

Here are the top foods sources:

  • Pork heart
  • Pork liver
  • Beef heart
  • Beef liver
  • Chicken liver
  • Chicken heart
  • Sardine
  • Mackerel

If you are a vegan there ARE  vegetable sources of Coenzyme Q10, the best are whole grains, peanuts, wheat germ, broccoli, and spinach. Keep in mind though that these sources are a lot lower in CoQ10 than animal proteins, so if you are trying to make up for a deficiency in Coenzyme Q10 you may need to use a supplement like ubiquinol if you are eating a vegan diet.

Health Benefits of Coenzyme Q10

There are many health benefits of Coenzyme Q10 from protecting yourself from heart disease, to blood sugar control and better energy.  Here is a short list of medical conditions where Coenzyme Q10 can be beneficial:

  • Malignant Melanoma
  • Diabetes
  • Endothelial Dysfunction
  • Heart Disease
  • Alzheimer’s Disease
  • Senile Dementia
  • Hypertension (high blood pressure)

CoQ10 is both an antioxidant and a bio-energetic nutrient, which means it both protects cells against oxidative stress (which robs the cells of energy) and also has a vital role in making the ATP molecule that supplies energy that cells need to maintain and repair themselves.

Coenzyme Q10 and Cholesterol

CoQ10 has beneficial effects on cholesterol profiles because of it’s role as a powerful antioxidant and free radical scavenger.  It’s been established that heart disease results from inflammation and free radical damage to the heart and the arteries through which blood flows.

By fighting oxidative stress and the free radicals it produces, CoQ10 can help prevent the damage to the endothelium and the process of atherosclerosis that causes coronary artery disease. The effect of CoQ10 on cholesterol is that it will raise good cholesterol (HDL) and lower LDL.

Even though we have learned recently that cholesterol does not CAUSE heart disease, it is a FACTOR in atherosclerosis that damages arteries. Coenzyme Q10 has been shown to alter the ratio of HDL to LDL that helps protect against coronary artery disease.

Cardiologists like Dr. Stephen Sinatra have been using Coenzyme Q10 to treat heart disease for many years, and now his colleagues are beginning to embrace this nutrient and add it to their treatment protocols, because of it’s ability to raise good cholesterol and lower inflammatory LDL particles.

Coenzyme Q10 and Statins

Statins, the drugs most often given to people to lower cholesterol have some very serious side effects. Some prominent cardiologists have come out against widespread statin use because the benefits of these drugs are far outweighed by the dangers to health that these drugs pose.

Statins deplete Coenzyme Q10, leaving the body vulnerable to a number of damaging processes that are rooted in oxidative stress and free radical damage. It is for this reason that a number of cardiologists recommend that in cases where statins are used the patient MUST be given Coenzyme Q10 in supplement form to protect against this statin caused deficiency.

The Case for Co Q10

Cardiologists are starting to use it, and in fact it has been used for many years in Japan to treat heart disease. Incidentally the Japanese are the longest lived population in the world, so it seems they know a thing or two about the health benefits of Coenzyme Q10.

The ability to raise good cholesterol with Coenzyme Q10 is the real value of this nutrient in helping to treat and prevent heart disease. Given the fact that heart disease is the number one killer of Americans, Coenzyme Q10 may prove to be one of the most effective strategies to keep your cardiovascular system healthy and extend your life.