pantethine-capsulesGood cholesterol levels can be achieved easily and naturally using pantethine, which is what I call a heart healthy nutritional supplement.

It is a derivative of vitamin b5 and it’s made up of two molecules of pantothenic acid linked together by what’s called a cysteamine bridge.

It is an intermediate step in the synthesis of  Coenzyme A, which in turn is involved in various enzymatic reactions including the production and oxidation of fatty acids.

pantethine molecule

Pantethine is what’s called the “active” (more biologically available) form of the vitamin b5, but unlike the more well known form calcium pantothenate, it is less stable and will degrade if not refrigerated.

The theory is that since it’s closer biochemically to coenzyme A, it is more beneficial than pantothenic acid. It’s involved in the activation of coenzyme A and helps transport fatty acids across the cell membrane into the mitochondria to be used to make ATP, (a key component in health).

However as you will see it’s benefits go far beyond improving your cholesterol hdl ratio!

How does it work and what does it do?

Biochemistry details aside, the bottom line for the average person is “what does it do?” Dr. Stephen Sinatra has stated that in every type of heart disease, what we find is an energy starved heart! The role of pantethine in cellular energy production is a big part of it’s beneficial effect on heart health.

The heart is a very energy intense organ, and the ability for the cells of the heart to produce  energy in the form of ATP affects every aspect of your heart function, from contraction to the electrical signaling that keeps your heart beating strongly and evenly.

Pantethine is right in the middle of all of this because it is a key player in the production of ATP in the mitochondria of your cells. In plain English, it boosts energy not only to your heart, but all the organs and systems of your body!

It  has been shown (in animal experiments) to lower LDL cholesterol and raise hdl cholesterol, improving the cholesterol hdl ratio, as well as decreasing triglycerides. The ability of pantethine to promote good cholesterol levels is highly beneficial to heart health.

In addition is increases levels of apolipoprotein A1, which is the component of HDL responsible for transporting cholesterol away from the arteries and back to the liver. Pantethine also functions as an anti stress nutrient, due to the fact that it supports the health of your adrenal glands and protects the health of your hormonal system particularly when you are under stress.

Pantethione also protects your brain in several ways. It promotes the synthesis of Coenzyme A (CoA) which in turn is used in the production of the neurotransmitter acetylcholine, which is critical for healthy brain function, and a lack of this neurotransmitter can lead to Alzheimer’s Disease.

It’s positive effect on the synthesis of CoA improves the efficiency of your heart and in turn improves blood flow to the brain. Pantethine has also been shown to be beneficial for the immune system, detoxification, arthritis, and wound healing. It is used also to treat acne, and also for gout and CFS (chronic fatigue syndrome).

So the evidence is that pantethine…

  • Improves hdl cholesterol levels
  • Improves ldl cholesterol level
  • Protects the brain by boosting acetylcholine
  • Improves heart function and blood flow
  • Can be used to treat acne
  • Is helpful in Chronic Fatigue Syndrome
  • Improves detoxification
  • Strengthens the immune system
  • Combats arthritis
  • Can be used to treat gout

How is it taken (form and dosage)

Pantethine as a nutritional supplement is taken orally in capsule form. Clinical research protocols have used as little as 300mg per day with statistically significant result. Levels of 600mg to 900mg have been used in research and yielded very significant reductions in LDL levels for subjects with elevated cholesterol levels. In general though there is little information to use as a guide for precise dosage levels.

Remember that where dosages are concerned, more is not necessarily better. The best course of action would be to use this supplement under the guidance of a complementary physician who can do follow up blood work and determine the correct dosage based on that.

This supplement should work at a relatively low dose, even as low as 5mg to 50mg per day. Start with the lowest dosage and work upwards until you find what works for you.

There are home cholesterol tests that you could use to establish a baseline reference and follow up test would tell you if the pantethine was having an effect. You would have to be careful to account for all the variables in your diet and activity level, and even at that it would not be a “scientifically accurate” result, but enough for you to determine whether pantethine was actually promoting good cholesterol levels.

Side effects

Large amounts of this supplement could potentially block absorption of other b vitamins. It could also cause fatigue, numbness in your hands and feet, or headaches. It’s effect on peristalsis could cause more frequent bowel movements or diarrhea.

The toxicity of this supplement is extremely low, and it has been termed “well tolerated” which is medical jargon for having few side effects. It is not likely that toxicity would be a problem at the dosages that would have benefit.

Brands to look for

Brands I like are:  Jarrow Formulas, Life Extension, and Pure Encapsulations. You really can’t go wrong with these companies when it comes to the quality of the supplements they sell. To be sure there are other good brands, but these are the ones I know of to be top notch.

To Sum Up

This is a supplement that can be helpful in many conditions due to it’s vital role in cellular energy production. Think of it less as something “medicinal” and more as a substance your body needs to create energy that powers all of your biochemical reactions.

Pantethine can be a powerful addition to your nutritional arsenal when it comes to promoting good cholesterol levels, combating heart disease and protecting your brain function. This article should be a starting point for your investigation and use of this fascinating supplement!

Raise good cholesterol with Coenzyme Q10, and lower inflammatory LDL particles at the same time.  Sure sounds like a win-win situation for heart health, and recent research strongly supports this important role for Co Q10!

coenzyme q10 moleculeLets take a look at this new nutritional weapon against heart disease, and the other health benefits of Coenzyme Q10.

What’s Coenzyme Q10?

Coenzyme Q10 or CoQ10 as it is also referred to, was discovered by Professor Fredrick L. Crane and his research team at the University of Wisconsin–Madison Enzyme Institute in 1957.

The reduced form of CoQ10 was called ubiquinone and was identified as a powerful antioxidant and free radical scavenger, and as we will see…it also has the ability to raise good cholesterol and lower inflammatory LDL.

This fat soluble antioxidant is found in the membrane structure of the mitochondria and is a key player in the electron transport chain which functions as an energy creating mechanism in your cells. The end product of these reactions is the creation of ATP, the primary source of energy for your body.

Because of it’s vital role in cellular energy production CoQ10 is found in highest amounts in the organs and tissue that have the highest energy demands.  Your body can synthesize CoQ10 but you also need to acquire it from your diet and possibly from supplementation as well.

How Do You Get Coenzyme Q10?

You can get CoQ10 in tablet form or as a soft-gel. The softgel form is superior because it’s easier for your body to absorb. The usual dose when used to benefit the heart is from 50 to 150 milligrams. The most effective form is the “reduced” form which is called “ubiquinol.”

Food sources of CoQ10 tend to be from animal sources, such as organ meats like liver, heart, as well as muscle. Again this is because those types of organs and tissues have a high demand for energy, and CoQ10 is a vital component of energy production in both animals and humans.

Here are the top foods sources:

  • Pork heart
  • Pork liver
  • Beef heart
  • Beef liver
  • Chicken liver
  • Chicken heart
  • Sardine
  • Mackerel

If you are a vegan there ARE  vegetable sources of Coenzyme Q10, the best are whole grains, peanuts, wheat germ, broccoli, and spinach. Keep in mind though that these sources are a lot lower in CoQ10 than animal proteins, so if you are trying to make up for a deficiency in Coenzyme Q10 you may need to use a supplement like ubiquinol if you are eating a vegan diet.

Health Benefits of Coenzyme Q10

There are many health benefits of Coenzyme Q10 from protecting yourself from heart disease, to blood sugar control and better energy.  Here is a short list of medical conditions where Coenzyme Q10 can be beneficial:

  • Malignant Melanoma
  • Diabetes
  • Endothelial Dysfunction
  • Heart Disease
  • Alzheimer’s Disease
  • Senile Dementia
  • Hypertension (high blood pressure)

CoQ10 is both an antioxidant and a bio-energetic nutrient, which means it both protects cells against oxidative stress (which robs the cells of energy) and also has a vital role in making the ATP molecule that supplies energy that cells need to maintain and repair themselves.

Coenzyme Q10 and Cholesterol

CoQ10 has beneficial effects on cholesterol profiles because of it’s role as a powerful antioxidant and free radical scavenger.  It’s been established that heart disease results from inflammation and free radical damage to the heart and the arteries through which blood flows.

By fighting oxidative stress and the free radicals it produces, CoQ10 can help prevent the damage to the endothelium and the process of atherosclerosis that causes coronary artery disease. The effect of CoQ10 on cholesterol is that it will raise good cholesterol (HDL) and lower LDL.

Even though we have learned recently that cholesterol does not CAUSE heart disease, it is a FACTOR in atherosclerosis that damages arteries. Coenzyme Q10 has been shown to alter the ratio of HDL to LDL that helps protect against coronary artery disease.

Cardiologists like Dr. Stephen Sinatra have been using Coenzyme Q10 to treat heart disease for many years, and now his colleagues are beginning to embrace this nutrient and add it to their treatment protocols, because of it’s ability to raise good cholesterol and lower inflammatory LDL particles.

Coenzyme Q10 and Statins

Statins, the drugs most often given to people to lower cholesterol have some very serious side effects. Some prominent cardiologists have come out against widespread statin use because the benefits of these drugs are far outweighed by the dangers to health that these drugs pose.

Statins deplete Coenzyme Q10, leaving the body vulnerable to a number of damaging processes that are rooted in oxidative stress and free radical damage. It is for this reason that a number of cardiologists recommend that in cases where statins are used the patient MUST be given Coenzyme Q10 in supplement form to protect against this statin caused deficiency.

The Case for Co Q10

Cardiologists are starting to use it, and in fact it has been used for many years in Japan to treat heart disease. Incidentally the Japanese are the longest lived population in the world, so it seems they know a thing or two about the health benefits of Coenzyme Q10.

The ability to raise good cholesterol with Coenzyme Q10 is the real value of this nutrient in helping to treat and prevent heart disease. Given the fact that heart disease is the number one killer of Americans, Coenzyme Q10 may prove to be one of the most effective strategies to keep your cardiovascular system healthy and extend your life.